๐ Aldigesic P 100mg/325mg Tablet – Fast and effective relief from everyday pain.
Aldigesic P 100mg/325mg Tablet
Product Introduction
Aldigesic P 100mg/325mg Tablet combines two effective pain-relieving medications—Aceclofenac (100mg) and Paracetamol (325mg)—creating a powerful dual-action formulation designed to address multiple pathways of pain and inflammation. This fixed-dose combination provides comprehensive relief for patients suffering from various painful conditions, offering both anti-inflammatory effects and centrally-acting analgesic properties in a single convenient tablet.
Aceclofenac, a non-steroidal anti-inflammatory drug (NSAID) of the phenylacetic acid class, works primarily by inhibiting cyclooxygenase enzymes responsible for prostaglandin synthesis, which are key mediators of inflammation, pain, and fever. It demonstrates notable efficacy against inflammatory conditions while exhibiting a more favorable gastrointestinal safety profile compared to traditional NSAIDs. Paracetamol (also known as acetaminophen) complements this action through its central analgesic and antipyretic effects, predominantly working on the central nervous system to modulate pain perception and reduce fever.
This synergistic combination allows for enhanced pain relief through different but complementary mechanisms, potentially providing more effective symptom control at lower doses of each individual component. This may translate to a reduced risk of side effects while maintaining therapeutic efficacy. The combination is particularly valuable for managing conditions where both pain and inflammation are present, such as osteoarthritis, rheumatoid arthritis, musculoskeletal disorders, and post-traumatic or post-operative pain.
Aldigesic P is typically prescribed for short to medium-term pain management, offering rapid onset of action and sustained relief throughout the dosing period. The dual-component formula helps address the multifaceted nature of pain, targeting both peripheral inflammatory processes and central pain perception pathways. This makes it a versatile option for various painful conditions ranging from acute injuries to chronic degenerative joint disorders.
While providing effective pain relief, Aldigesic P should be used at the lowest effective dose for the shortest duration necessary to control symptoms, as with all NSAID-containing medications. Regular assessment by healthcare providers is recommended, particularly for patients requiring extended treatment courses or those with pre-existing medical conditions that might increase their risk of adverse effects.
Key Composition & Ingredients
- Active Ingredients:
- Aceclofenac 100mg - A non-steroidal anti-inflammatory drug (NSAID)
- Paracetamol 325mg (Acetaminophen) - A non-opioid analgesic and antipyretic
- Inactive Ingredients: May include microcrystalline cellulose, croscarmellose sodium, povidone, magnesium stearate, colloidal silicon dioxide, and other pharmaceutical excipients
Uses of Aldigesic P Tablet
- Relief of pain and inflammation in osteoarthritis
- Management of rheumatoid arthritis symptoms
- Treatment of ankylosing spondylitis
- Relief of musculoskeletal pain and inflammation
- Management of post-traumatic pain
- Relief of post-operative pain
- Treatment of dental pain
- Management of primary dysmenorrhea (menstrual pain)
- Relief of acute back pain
- Symptomatic treatment of fever associated with painful conditions
Benefits of Aldigesic P Tablet
- Provides dual-action pain relief through complementary mechanisms
- Offers enhanced analgesic effect compared to individual components alone
- Reduces inflammation while also addressing central pain perception
- Faster onset of action compared to some single-agent therapies
- More comprehensive symptom control in inflammatory conditions
- Potentially allows for lower doses of each component, reducing risk of side effects
- Convenient single-tablet administration improving treatment adherence
- Provides both analgesic and antipyretic effects
- Effectively manages both acute and chronic pain conditions
- May provide better tolerability than higher doses of NSAIDs alone
How Aldigesic P Tablet Works (Mechanism of Action)
Aldigesic P combines two medications with different but complementary mechanisms:
-
Aceclofenac (100mg):
- Primarily inhibits cyclooxygenase enzymes (COX-1 and COX-2), preventing prostaglandin synthesis
- Reduces inflammation, pain, and fever at peripheral sites of inflammation
- May preferentially inhibit COX-2, contributing to its improved gastric tolerance
- Also inhibits pro-inflammatory cytokines like IL-1, IL-6, and TNF-ฮฑ
- Reduces migration of leukocytes into inflamed tissue
-
Paracetamol (325mg):
- Acts centrally to inhibit prostaglandin synthesis in the central nervous system
- Modulates pain perception through effects on serotonergic pathways
- Inhibits the endocannabinoid reuptake system, contributing to pain relief
- Reduces fever by acting on the hypothalamic heat-regulating center
- May selectively inhibit a central COX variant (sometimes called COX-3)
Dosage of Aldigesic P Tablet
- Standard Adult Dosage: One tablet twice daily, typically taken in the morning and evening
- Maximum Dosage: Generally not more than two tablets in 24 hours
- Duration: Use at the lowest effective dose for the shortest duration possible
- Administration: Preferably taken with or after meals to minimize gastrointestinal side effects
- Missed Dose: Take as soon as remembered if not close to next dose time; do not double dose
- Overdose: Symptoms may include nausea, vomiting, liver damage, or kidney problems; seek immediate medical attention
Mode of Action of Aldigesic P Tablet
The dual mechanism of Aldigesic P provides comprehensive pain control:
- Aceclofenac targets peripheral inflammatory pain by inhibiting prostaglandin synthesis at the site of inflammation
- Paracetamol works centrally to reduce pain perception and lower fever
- The combination addresses both the source of pain (inflammation) and the perception of pain (central processing)
- This multi-pathway approach provides more complete pain relief than either agent alone
How to Use Aldigesic P Tablet
- Take exactly as prescribed by your physician
- Swallow the tablet whole with a full glass of water
- Take with or after food to minimize stomach irritation
- Maintain an upright position for 15-30 minutes after taking the medication
- Do not crush, chew, or break the tablet unless specifically directed by your doctor
- Space doses evenly throughout the day for consistent pain control
- Use only for the prescribed duration; prolonged use increases risk of side effects
Side Effects of Aldigesic P Tablet
Common side effects:
- Indigestion or stomach discomfort
- Nausea
- Mild abdominal pain
- Dizziness
- Headache
- Increased liver enzymes (usually temporary and mild)
Serious side effects (require immediate medical attention):
- Severe gastric pain or signs of gastrointestinal bleeding (black tarry stools)
- Signs of liver problems (yellowing of skin/eyes, dark urine, persistent fatigue)
- Allergic reactions (skin rash, itching, swelling)
- Unusual bruising or bleeding
- Swelling of feet or ankles
- Chest pain or shortness of breath
- Severe skin reactions
Safety Advice for Aldigesic P Tablet
- Alcohol: Avoid completely; increases risk of liver damage and gastrointestinal bleeding
- Pregnancy: Not recommended, especially in the third trimester; consult doctor
- Breastfeeding: Use with caution; consult doctor before use
- Driving: May cause dizziness; assess individual response before driving
- Kidney Function: Use with caution in mild to moderate impairment; avoid in severe impairment
- Liver Function: Use with caution in mild to moderate impairment; avoid in severe liver disease
- Children: Not recommended for children under 18 years unless specifically prescribed
- Older Patients: May need lower doses due to increased risk of side effects
- Allergies: Avoid if allergic to aceclofenac, paracetamol, other NSAIDs, or any components
Warnings & Precautions for Aldigesic P Tablet
- History of peptic ulcers or gastrointestinal bleeding
- Cardiovascular disease or risk factors
- Hypertension (high blood pressure)
- Renal or hepatic impairment
- Asthma or history of bronchospasm with aspirin/NSAIDs
- Concomitant use of anticoagulants
- History of alcohol abuse
- Dehydration
- Use with caution in elderly patients
- Avoid use with other paracetamol-containing products to prevent overdose
- Discontinue if signs of liver damage, skin reactions, or GI bleeding occur
Interactions with Aldigesic P Tablet
Drug Interactions:
- Anticoagulants (warfarin): Increased bleeding risk
- Other NSAIDs or aspirin: Enhanced side effects
- Corticosteroids: Increased risk of gastrointestinal ulceration
- Diuretics and antihypertensives: Reduced effectiveness
- Methotrexate: Increased toxicity
- Lithium: Increased plasma concentration and toxicity
- Cyclosporine: Increased nephrotoxicity
- Antidiabetic agents: May alter blood glucose control
- Other paracetamol-containing products: Risk of overdose
Food Interactions:
- Food may delay absorption but reduces gastrointestinal side effects
- Avoid alcohol while taking this medication
Contraindications of Aldigesic P Tablet
- Active or history of recurrent peptic ulcer/GI bleeding
- Severe heart failure
- Severe kidney or liver dysfunction
- History of gastrointestinal perforation related to NSAID therapy
- Third trimester of pregnancy
- Hypersensitivity to aceclofenac, paracetamol, or other NSAIDs
- Patients with aspirin-induced asthma, urticaria, or allergic reactions
- Concurrent use of other NSAID-containing products
- Hemophilia or other bleeding disorders
Diet & Lifestyle Advice
- Maintain adequate hydration while taking this medication
- Follow an anti-inflammatory diet rich in fruits, vegetables, and omega-3 fatty acids
- Consider weight management if overweight to reduce pressure on painful joints
- Practice appropriate physical therapy and exercise as recommended
- Use cold or heat therapy as appropriate for the condition
- Ensure proper ergonomics at work and home to prevent musculoskeletal strain
- Consider stress reduction techniques as stress can exacerbate pain perception
- Avoid smoking as it may impair healing and worsen inflammatory conditions
Why Doctors Recommend This Medicine
Physicians recommend Aldigesic P when patients require comprehensive pain management addressing both inflammatory and central pain mechanisms. The combination provides more complete relief than either medication alone, potentially at lower doses, which may improve the safety profile while maintaining efficacy. The convenient twice-daily dosing improves treatment adherence compared to more frequent dosing regimens.
Substitutes of Aldigesic P Tablet & Alternative Medicines
- Aceclofenac + Paracetamol from different manufacturers
- Diclofenac + Paracetamol combinations
- Ibuprofen + Paracetamol combinations
- Naproxen + Paracetamol combinations
- Aceclofenac or other NSAIDs alone
- Paracetamol alone
- COX-2 selective inhibitors (celecoxib, etoricoxib)
- Topical NSAID preparations for localized pain
Storage Guidelines
- Store at room temperature between 15-30°C (59-86°F)
- Keep away from direct sunlight and moisture
- Keep in the original container with the lid tightly closed
- Store in a dry place away from heat
- Keep out of reach of children
- Do not use after the expiration date
- Do not store in bathroom medicine cabinets due to heat and humidity
Quick Tips for Aldigesic P Tablet
- Take with food or milk to minimize stomach irritation
- Use the lowest effective dose for the shortest duration possible
- Stay well-hydrated while taking this medication
- Do not take additional paracetamol-containing products simultaneously
- Report any unusual symptoms promptly to your healthcare provider
- Carry medical information about your medications when traveling
- Consider preventive strategies like physical therapy alongside medication
Fact Box
- Chemical Class: Phenylacetic acid derivative (Aceclofenac) + Para-aminophenol derivative (Paracetamol)
- Habit Forming: No
- Therapeutic Class: NSAID + Non-opioid analgesic
- Action Class: Cyclooxygenase inhibitor + Central analgesic
Useful Diagnostic Tests
- Liver function tests (particularly with extended use)
- Kidney function tests
- Complete blood count if long-term therapy is required
- Stool occult blood test if GI symptoms develop
- Blood pressure monitoring for patients with hypertension
- X-rays or other imaging for the underlying condition causing pain
Disclaimer
This information is for educational purposes only and not a substitute for professional medical advice. Always consult your healthcare provider before starting, stopping, or changing any treatment regimen. Individual responses to medication may vary.
Comments
Post a Comment