💊 Azel 80 Capsule – A trusted solution for prostate cancer, PCOS, and excessive hair growth.
Azel 80 Capsule
Product Introduction
Azel 80 Capsule contains Enzalutamide 80mg, a powerful anti-androgen medication primarily prescribed for the treatment of metastatic castration-resistant prostate cancer (mCRPC). This innovative therapeutic agent represents an important advancement in the management of advanced prostate cancer, offering hope to patients who have developed resistance to traditional hormone therapy.
Enzalutamide works through a unique mechanism that targets the androgen receptor signaling pathway, which plays a crucial role in prostate cancer growth and progression. By effectively blocking multiple steps in this pathway, Azel 80 helps inhibit cancer cell growth and proliferation, potentially extending survival and improving quality of life for patients with advanced prostate cancer.
Developed after extensive clinical research, Enzalutamide has demonstrated significant efficacy in various clinical trials, showing improvements in overall survival, radiographic progression-free survival, and time to PSA progression in men with mCRPC. The medication is designed for oral administration, making it convenient for patients to take at home under medical supervision.
As a second-generation anti-androgen, Enzalutamide offers advantages over earlier treatments, including greater affinity for androgen receptors and the ability to overcome some mechanisms of resistance that develop with first-generation drugs. Azel 80 represents an important component in the modern treatment arsenal against advanced prostate cancer.
This prescription medication requires careful monitoring by healthcare professionals to manage potential side effects and ensure optimal therapeutic outcomes. The treatment journey with Azel 80 typically involves regular follow-up appointments, blood tests, and imaging studies to assess response and adjust therapy as needed.
Key Composition & Ingredients
- Active Ingredient: Enzalutamide 80mg
- Inactive Ingredients: May contain caprylocaproyl polyoxylglycerides, butylated hydroxyanisole, butylated hydroxytoluene, gelatin capsule shell, sorbitol sorbitan solution, glycerol, titanium dioxide, purified water, and pharmaceutical-grade coloring agents
Uses of Azel 80 Capsule
- Treatment of metastatic castration-resistant prostate cancer (mCRPC)
- Treatment of non-metastatic castration-resistant prostate cancer (nmCRPC)
- Treatment of metastatic hormone-sensitive prostate cancer (mHSPC)
- In combination with androgen deprivation therapy (ADT) for advanced prostate cancer
Benefits of Azel 80 Capsule
- Extends overall survival in patients with advanced prostate cancer
- Delays disease progression and development of new metastases
- Improves quality of life by potentially reducing cancer-related symptoms
- Delays the need for cytotoxic chemotherapy
- Potentially preserves physical function and independence longer
- May reduce cancer pain and the need for pain medications
- Can be effective in patients whose cancer has progressed on other hormonal therapies
- Convenient oral administration allows for home-based treatment
How Azel 80 Capsule Works
Enzalutamide is an androgen receptor inhibitor that works through multiple mechanisms:
- It competitively inhibits binding of androgens (male hormones like testosterone) to androgen receptors
- It prevents nuclear translocation of activated androgen receptors
- It inhibits the association of activated androgen receptors with DNA
- It blocks androgen receptor-mediated transcription of genes that promote cancer growth
By blocking these steps in the androgen receptor signaling pathway, Enzalutamide effectively prevents prostate cancer cells from responding to androgens that stimulate their growth, thereby slowing cancer progression.
Dosage of Azel 80 Capsule
Daily Dose
- Standard dose: 160mg (two 80mg capsules) once daily
- Duration: Continued until disease progression or unacceptable toxicity occurs
Missed Dose
If you miss a dose at the usual time, take the prescribed dose as soon as you remember on the same day. If you miss a dose for the entire day, resume the normal schedule the following day. Do not take extra doses to make up for a missed dose.
Overdose
Symptoms of overdose may include increased risk of seizures, severe weakness, or more pronounced side effects. Seek immediate medical attention if overdose is suspected.
How to Use Azel 80 Capsule
- Take Azel 80 at the same time each day
- Swallow capsules whole with water
- Can be taken with or without food
- Do not crush, chew, or open the capsules
- Take exactly as prescribed by your doctor, usually 160mg (two 80mg capsules) once daily
- Continue taking for as long as prescribed, even if you feel well
Side Effects of Azel 80 Capsule
Common Side Effects
- Fatigue and asthenia (weakness)
- Hot flashes
- Headache
- Hypertension (high blood pressure)
- Dizziness
- Decreased appetite
- Joint pain
- Muscle weakness
- Back pain
- Diarrhea
Serious Side Effects
- Seizures (occurs in <1% of patients)
- Posterior reversible encephalopathy syndrome (PRES)
- Falls and fractures
- Severe hypersensitivity reactions
- Cardiovascular events (especially in patients with pre-existing heart disease)
- Severe liver injury (rare)
How to Manage Side Effects
- Regular medical follow-ups to monitor for side effects
- Blood pressure monitoring for hypertension
- Take precautions to prevent falls
- Report any unusual symptoms to your doctor promptly
- Adequate hydration and rest to manage fatigue
- Modification of dose if side effects are severe
Safety Advice for Azel 80 Capsule
Alcohol
Limit alcohol consumption as it may increase the risk of liver problems and enhance side effects like dizziness.
Pregnancy
Not indicated for use in women. However, men taking Enzalutamide who have female partners of childbearing potential should use effective contraception during treatment and for 3 months after the last dose.
Breast Feeding
Not applicable as the drug is indicated only for men.
Driving
May cause dizziness, seizures, and fatigue. Avoid driving until you know how the medication affects you.
Kidney
Use with caution in severe renal impairment. No dose adjustment is typically required for mild to moderate renal impairment.
Liver
Use with caution in moderate to severe liver impairment. Dose adjustment may be necessary. Regular liver function monitoring is recommended.
Children
Not indicated for use in pediatric patients.
Older Patients
No specific dose adjustment needed for elderly patients, but monitor closely for side effects.
Allergy
Avoid if you have known hypersensitivity to Enzalutamide or any components of the formulation.
Warnings & Precautions of Azel 80 Capsule
- History of seizures or conditions that might predispose to seizures
- History of brain injury, stroke, or brain tumors
- Taking medications that may lower seizure threshold
- Risk of falls and fractures due to effects on the central nervous system
- Regular monitoring of blood pressure required
- May affect cognitive function and mental health
- Can cause significant fatigue which may impact daily activities
- May interact with many other medications
- Men with female partners who can become pregnant should use contraception during and for 3 months after treatment
Interactions with Azel 80 Capsule
Drug-Drug Interactions
- Strong CYP2C8 inhibitors (e.g., gemfibrozil): May increase Enzalutamide levels; avoid concomitant use
- Strong CYP3A4 inducers (e.g., rifampin, phenytoin, carbamazepine, St. John's Wort): May decrease Enzalutamide effectiveness
- CYP3A4, CYP2C9, and CYP2C19 substrates (e.g., warfarin, phenytoin): Enzalutamide may decrease their effectiveness
- P-glycoprotein (P-gp) substrates (e.g., digoxin): May require dose adjustment
Drug-Food Interactions
Food does not significantly affect the absorption of Enzalutamide; Azel 80 can be taken with or without food.
Contraindications of Azel 80 Capsule
- Known hypersensitivity to Enzalutamide or any excipients in the formulation
- Women who are or may become pregnant
- Not recommended for patients with severe hepatic impairment (Child-Pugh Class C)
Diet & Lifestyle Advice
- Maintain regular physical activity as tolerated
- Follow a balanced diet rich in fruits, vegetables, and whole grains
- Stay well-hydrated throughout the day
- Take precautions to prevent falls, especially if experiencing dizziness
- Consider bone health with adequate calcium and vitamin D intake
- Regular monitoring of blood pressure
- Stress management techniques may help with overall well-being
- Regular follow-up appointments with healthcare providers
Why Doctors Recommend This Medicine
Doctors prescribe Azel 80 when:
- A patient has metastatic castration-resistant prostate cancer
- A patient has non-metastatic castration-resistant prostate cancer with high risk of metastasis
- The cancer has progressed despite androgen deprivation therapy
- There is a need for treatment that can delay the use of chemotherapy
- Other hormonal treatments have failed or are not suitable
- The benefits of treatment outweigh the potential risks for the individual patient
Substitutes & Alternative Medicines
- Abiraterone acetate (Zytiga)
- Apalutamide (Erleada)
- Darolutamide (Nubeqa)
- Bicalutamide (higher doses)
- Docetaxel and cabazitaxel (chemotherapy options)
- Radium-223 dichloride (for bone metastases)
- Sipuleucel-T (immunotherapy)
Storage Guidelines
- Store at room temperature between 20-25°C (68-77°F)
- Keep in the original container with the desiccant
- Protect from light and moisture
- Keep container tightly closed
- Keep out of reach of children
- Do not use after the expiration date printed on the package
User Feedback & Patient Concerns
Common feedback from patients includes:
- Improvement in overall wellbeing and energy levels for some patients
- Variable experiences with side effects, particularly fatigue
- Concerns about managing falls and maintaining mobility
- Questions about duration of treatment and what to expect
- Interest in monitoring PSA levels to track treatment success
- Management of hot flashes, which can affect quality of life
Quick Tips
- Keep a symptom diary to discuss with your doctor
- Take the medication at the same time each day to establish a routine
- Ensure regular blood tests to monitor liver function and PSA levels
- Report any unusual symptoms or side effects promptly
- Wear medical alert identification indicating you are taking this medication
- Store medication away from excessive heat or cold
- Avoid grapefruit juice, which may interact with many medications
Fact Box
- Chemical Class: Diarylthiohydantoin
- Habit Forming: No
- Therapeutic Class: Anti-androgen, Anti-neoplastic
- Action Class: Androgen receptor inhibitor
Useful Diagnostic Tests
- PSA (Prostate-Specific Antigen) levels
- Complete blood count
- Liver function tests
- Kidney function tests
- Blood pressure measurements
- Regular imaging (CT scans, bone scans) to assess disease status
- Electrocardiogram (ECG) in patients with cardiac risk factors
Disclaimer
This information is for educational purposes only and not a substitute for professional medical advice. Always consult your physician or healthcare provider before starting, stopping, or changing any treatment regimen. Individual results may vary, and side effects not listed here may occur in some patients. This medication should only be used under the supervision of a qualified healthcare professional specializing in oncology.
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