AB Phylline SR 200 Tablet – Uses, Side Effects & Dosage Guide

AB Phylline SR 200 Tablet

Prescription Required

Marketer

Sun Pharmaceutical Industries Ltd

SALT COMPOSITION

Acebrophylline (200mg)

Storage

Store below 30°C

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Product Introduction

AB Phylline SR 200 Tablet is a sustained-release formulation containing Acebrophylline, a potent bronchodilator medication primarily used to manage respiratory conditions such as asthma, chronic bronchitis, and chronic obstructive pulmonary disease (COPD). This advanced formulation delivers a consistent release of the active ingredient over an extended period, providing longer-lasting relief from breathing difficulties with fewer daily doses.

Acebrophylline belongs to the xanthine derivative class of medications and combines the benefits of theophylline with an ambroxol-like component. This dual-action approach not only helps in bronchodilation (opening up of the airways) but also provides mucolytic properties that help break down thick mucus, making it easier to expel from the respiratory tract.

The sustained-release technology in AB Phylline SR 200 Tablet ensures that therapeutic levels of the medication are maintained in the bloodstream throughout the day, reducing the frequency of administration and enhancing patient compliance. This makes it particularly beneficial for patients requiring long-term management of chronic respiratory conditions.

Unlike traditional bronchodilators that may cause significant cardiovascular side effects, AB Phylline SR 200 Tablet is designed to provide effective bronchodilation with a potentially improved safety profile. The tablet's unique formulation helps minimize the rapid rise and fall of drug concentration in blood, thus reducing the likelihood of dose-related adverse effects commonly associated with immediate-release xanthine derivatives.

AB Phylline SR 200 Tablet is generally prescribed as part of a comprehensive treatment plan for respiratory disorders. It works synergistically with other medications such as inhaled corticosteroids, making it a valuable component in the management of moderate to severe obstructive airway diseases. Regular use as prescribed by healthcare professionals can significantly improve lung function, reduce the frequency and severity of asthma attacks or COPD exacerbations, and enhance overall quality of life for patients with chronic respiratory conditions.

Key Composition & Ingredients

• Active Ingredient: Acebrophylline 200mg
• Pharmaceutical Form: Sustained-release tablet
• Inactive Ingredients: May include microcrystalline cellulose, hydroxypropyl methylcellulose (HPMC), magnesium stearate, colloidal silicon dioxide, and other pharmaceutical excipients that help control the release rate of the medication

Uses of AB Phylline SR 200 Tablet

• Treatment of bronchial asthma
• Management of chronic obstructive pulmonary disease (COPD)
• Relief from chronic bronchitis symptoms
• Management of emphysema
• Treatment of bronchospasm (narrowing of airways)
• Adjunctive therapy in respiratory tract infections

Benefits of AB Phylline SR 200 Tablet

• Provides sustained bronchodilation for easier breathing
• Reduces mucus viscosity for easier expectoration
• Decreases frequency of asthma attacks and COPD exacerbations
• Improves lung function parameters
• Reduces inflammation in the airways
• Requires fewer daily doses due to sustained-release formulation
• Enhances exercise tolerance and physical activity capacity
• Improves overall quality of life for respiratory condition patients
• Decreases hospitalization frequency in severe cases
• Works effectively in combination with other respiratory medications

How AB Phylline SR 200 Tablet Works

AB Phylline SR 200 Tablet contains Acebrophylline, which is a unique compound that combines the actions of theophylline and ambroxol. This dual mechanism provides both bronchodilatory and mucolytic effects:

1. Bronchodilatory Action: Inhibits phosphodiesterase enzymes, leading to increased levels of cyclic AMP (cAMP) in bronchial smooth muscle cells. Higher cAMP levels promote relaxation of bronchial smooth muscles, resulting in widened airways and improved airflow.
2. Anti-inflammatory Properties: Reduces inflammatory mediator release and inhibits the migration of inflammatory cells into the airways, decreasing inflammation that contributes to airway narrowing.
3. Mucolytic Effect: Stimulates surfactant production and improves mucociliary clearance by modifying the rheological properties of bronchial secretions, making mucus less viscous and easier to expectorate.
4. Enhanced Respiratory Muscle Function: Improves diaphragmatic contractility and prevents respiratory muscle fatigue, which helps in more efficient breathing.

Dosage of AB Phylline SR 200 Tablet

Daily Dose

• Adults and adolescents (>12 years): Typically one tablet (200mg) once or twice daily, as prescribed by the physician
• Duration: Long-term therapy as directed by healthcare provider, with periodic assessment

Missed Dose

• Take as soon as remembered if within a few hours
• Skip the missed dose if it's almost time for the next scheduled dose
• Do not double up to compensate for a missed dose

Overdose

• Symptoms may include nausea, vomiting, restlessness, tachycardia, seizures
• Seek immediate medical attention if overdose is suspected
• No specific antidote; treatment is symptomatic and supportive

How to Use AB Phylline SR 200 Tablet

• Swallow the tablet whole with a full glass of water
• Do not crush, chew, or break the tablet as this may affect the sustained-release properties
• Can be taken with or after food to minimize gastric irritation
• Take at the same time(s) each day to maintain consistent blood levels
• Follow the complete course as prescribed even if symptoms improve

Side Effects of AB Phylline SR 200 Tablet

Common Side Effects

• Nausea or vomiting
• Gastric discomfort or heartburn
• Headache
• Insomnia or sleep disturbances
• Mild dizziness

Uncommon Side Effects

• Palpitations or increased heart rate
• Tremors
• Anxiety or nervousness
• Muscle twitching
• Urinary frequency

Rare Side Effects

• Allergic reactions (rash, itching, swelling)
• Gastroesophageal reflux
• Arrhythmias
• Seizures (with very high blood levels)
• Electrolyte disturbances

How to Manage Side Effects

• Take with food to reduce gastrointestinal discomfort
• Stay hydrated throughout the day
• Report persistent or severe side effects to your doctor
• Dosage adjustment may be necessary if side effects are troublesome
• Regular monitoring of blood levels may be required in some cases

Safety Advice for AB Phylline SR 200 Tablet

Alcohol

CAUTION: Avoid alcohol consumption as it may increase the risk of side effects and alter the metabolism of the medication.

Pregnancy

CONSULT DOCTOR: Use only if clearly needed and benefits outweigh risks. Limited data available on safety during pregnancy.

Breastfeeding

CAUTION: May pass into breast milk. Consult healthcare provider before use during lactation.

Driving

CAUTION: May cause dizziness or tremors in some patients. Assess individual response before driving or operating machinery.

Kidney

CAUTION: Dose adjustment may be necessary in patients with renal impairment. Regular monitoring recommended.

Liver

CAUTION: Metabolism may be affected in liver disease. Lower doses may be required with close monitoring.

Children

NOT RECOMMENDED: Safety and efficacy not established in children under 12 years of age.

Older Patients

DOSE ADJUSTMENT: Lower initial doses typically recommended due to possible reduced clearance. Careful monitoring advised.

Allergy

CONTRAINDICATED: Do not use if allergic to Acebrophylline or any components of the formulation.

Warnings & Precautions

• Use with caution in patients with cardiac arrhythmias or cardiovascular disease
• Monitor therapy closely in patients with seizure disorders
• Use cautiously in those with peptic ulcer disease
• May interact with various medications, requiring dose adjustments
• Patients with hyperthyroidism may experience enhanced effects
• Regular monitoring recommended in patients with unstable respiratory status
• Use with caution in elderly patients and those with multiple comorbidities
• May affect blood glucose levels in diabetic patients

Interactions with AB Phylline SR 200 Tablet

Drug-Drug Interactions

• Increased effect with: Cimetidine, erythromycin, ciprofloxacin, oral contraceptives
• Decreased effect with: Rifampin, phenytoin, carbamazepine, barbiturates
• Potential adverse interactions with: Beta-blockers, benzodiazepines
• Additive effects with: Other bronchodilators, caffeine

Drug-Food Interactions

• High-protein diets may decrease drug levels
• Charcoal-broiled foods may increase clearance
• Caffeine-containing foods and beverages may enhance side effects

Contraindications of AB Phylline SR 200 Tablet

• Hypersensitivity to Acebrophylline or any component
• Active peptic ulcer disease
• Uncontrolled cardiac arrhythmias
• Seizure disorders not controlled by medication
• Severe hypertension
• Acute myocardial infarction
• Children under 12 years of age

Diet & Lifestyle Advice

• Maintain adequate hydration to help thin mucus secretions
• Avoid or minimize exposure to known respiratory triggers
• Practice breathing exercises as recommended by healthcare providers
• Maintain a healthy weight to reduce respiratory effort
• Follow a balanced diet rich in antioxidants and anti-inflammatory foods
• Quit smoking and avoid second-hand smoke exposure
• Implement dust and allergen control measures at home
• Regular physical activity as tolerated and recommended

Why Doctors Recommend This Medicine

Physicians often prescribe AB Phylline SR 200 Tablet because of its:

• Dual bronchodilatory and mucolytic action
• Sustained release formulation requiring fewer daily doses
• Effectiveness in both acute and maintenance therapy
• Good tolerability profile compared to some alternatives
• Compatibility with other asthma and COPD medications
• Improvement in quality of life parameters for respiratory patients

Substitutes of AB Phylline SR 200 Tablet

• Theophylline extended-release formulations
• Doxofylline tablets
• Bambuterol tablets
• Combination bronchodilator therapies
• Inhaled long-acting beta-agonists with corticosteroids

Note: Substitution should only be done under medical supervision

Storage Guidelines

• Store at room temperature (15-30°C)
• Keep away from direct sunlight and moisture
• Keep out of reach of children
• Do not use after the expiration date
• Store in the original package or container

Quick Tips

• Take consistently at the same time each day
• Avoid abruptly discontinuing the medication
• Carry medical identification indicating you are on this medication
• Inform all healthcare providers about this medication
• Regular follow-up with your doctor is essential
• Report any unusual side effects promptly
• Periodic lung function tests may be needed to assess effectiveness

Fact Box

• Chemical Class: Xanthine derivative with ambroxol component
• Habit Forming: No
• Therapeutic Class: Bronchodilator and mucolytic
• Action Class: Phosphodiesterase inhibitor with anti-inflammatory properties

Useful Diagnostic Tests

• Pulmonary function tests (PFTs)
• Blood gas analysis (in severe cases)
• Chest X-ray
• Therapeutic drug monitoring (if toxicity suspected)
• Complete blood count and basic metabolic panel
• Electrocardiogram (in patients with cardiovascular risk)

Disclaimer

This information is provided for educational purposes only and is not intended as a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of information you have read here.