Acemiz Plus Tablet – Pain Relief Medicine for Muscle, Joint, Dental Pain & Headache

Acemiz Plus Tablet

Prescription Required

Marketer

Lupin Ltd

SALT COMPOSITION

Aceclofenac (100mg) + Paracetamol (325mg)

Storage

Store below 30°C

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Introduction

Acemiz Plus Tablet combines two powerful pain-relieving agents—Aceclofenac (100mg) and Paracetamol (325mg)—to provide enhanced and effective relief from various painful conditions. This dual-action formulation offers superior analgesic and anti-inflammatory benefits compared to either component used alone, making it a preferred choice among healthcare providers for managing moderate to severe pain.

Aceclofenac, a non-steroidal anti-inflammatory drug (NSAID), effectively reduces inflammation, pain, and stiffness associated with numerous musculoskeletal conditions. It works by inhibiting the production of inflammatory substances in the body called prostaglandins. Meanwhile, Paracetamol (also known as Acetaminophen) enhances the pain-relieving action through its central effect on pain perception pathways in the brain.

The strategic combination in Acemiz Plus Tablet provides comprehensive pain management by targeting pain through multiple mechanisms. This synergistic action not only improves the efficacy but also allows for lower doses of each component, potentially reducing the risk of side effects associated with higher doses of individual medications.

Commonly prescribed for conditions like arthritis, back pain, dental pain, post-operative pain, and musculoskeletal injuries, Acemiz Plus Tablet is valued for its rapid onset of action and sustained pain relief. The medication typically begins working within 30 minutes to an hour after consumption, with effects lasting several hours, providing meaningful comfort to patients suffering from painful conditions.

While generally well-tolerated when used as directed, Acemiz Plus Tablet should be taken under medical supervision, particularly for individuals with pre-existing health conditions such as gastric disorders, cardiovascular issues, kidney or liver impairment. The medication is designed for short-term use in most cases, though your healthcare provider may prescribe longer courses for chronic conditions with appropriate monitoring.

This comprehensive guide provides detailed information about Acemiz Plus Tablet, including its composition, uses, benefits, mechanism of action, proper dosage guidelines, potential side effects, safety considerations, and more. Understanding this information will help you use this medication safely and effectively to manage pain and inflammation while minimizing potential risks.

Key Composition & Ingredients

• Active Ingredients:
  • Aceclofenac (100mg)
  • Paracetamol (325mg)
• Inactive Ingredients: May include microcrystalline cellulose, croscarmellose sodium, povidone, magnesium stearate, colloidal silicon dioxide, and film coating materials (specific inactive ingredients may vary by manufacturer)

Uses of Acemiz Plus Tablet

Acemiz Plus Tablet is prescribed for the management of:

• Osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis
• Acute musculoskeletal pain and inflammation
• Lower back pain and chronic back conditions
• Post-traumatic pain (sprains, strains, and injuries)
• Post-operative pain following surgery
• Dental pain and inflammation
• Menstrual pain (dysmenorrhea)
• Fever associated with inflammatory conditions
• Headache and migraine pain
• Joint pain and stiffness

Benefits of Acemiz Plus Tablet

• Enhanced Pain Relief: Dual mechanism provides more complete pain control than single agents
• Reduced Inflammation: Effectively decreases swelling, redness, and warmth in inflamed areas
• Improved Mobility: Helps restore movement and function in painful joints and muscles
• Fever Reduction: Effectively lowers elevated body temperature
• Convenient Dosing: Typically requires fewer daily doses than some alternative pain medications
• Better Tolerability: Combination allows for lower doses of each component
• Rapid Onset: Begins working quickly, usually within 30-60 minutes
• Extended Duration: Provides sustained relief for several hours
• Improved Quality of Life: Enables better sleep, increased activity levels, and improved daily functioning

How Acemiz Plus Tablet Works (Mechanism of Action)

Acemiz Plus Tablet works through the combined mechanisms of its two active ingredients:

Aceclofenac (100mg):

1. Primarily inhibits cyclooxygenase-2 (COX-2) enzymes with moderate effects on COX-1
2. This inhibition blocks the production of prostaglandins, which are key mediators of inflammation and pain
3. Reduces the release of inflammatory cytokines and interleukins
4. Decreases free radical production at the site of inflammation
5. May also inhibit pro-inflammatory cytokine interleukin-1 (IL-1)

Paracetamol (325mg):

1. Acts primarily in the central nervous system by inhibiting a variant of cyclooxygenase called COX-3
2. Reduces the production of prostaglandins in the brain and spinal cord
3. Impacts neurotransmitter systems involved in pain perception
4. Affects the endocannabinoid system which modulates pain
5. Has antipyretic (fever-reducing) effects through action on the hypothalamic heat-regulating center

The combination provides complementary actions: Aceclofenac primarily addresses peripheral inflammation while Paracetamol enhances pain relief through central mechanisms, resulting in more effective pain management than either component alone.

Dosage of Acemiz Plus Tablet

Standard Dosage

• Adults and adolescents over 14 years: Typically one tablet twice daily (morning and evening)
• Maximum daily dose: Two tablets (200mg Aceclofenac and 650mg Paracetamol) in 24 hours
• Duration: Usually prescribed for 5-7 days for acute conditions; longer use requires medical supervision

Missed Dose

If you miss a dose, take it as soon as you remember. However, if it's almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one.

Overdose

Overdose can be dangerous, particularly due to the paracetamol component. Symptoms may include nausea, vomiting, abdominal pain, pallor, sweating, and drowsiness in the early stages, followed by potential liver damage 24-48 hours later. Immediate medical attention is essential if overdose is suspected.

How to Use Acemiz Plus Tablet

• Take Acemiz Plus Tablet with food or milk to reduce the risk of stomach irritation
• Swallow the tablet whole with a full glass of water; do not crush, chew, or break it
• Take at the same times each day to maintain consistent blood levels
• Use the lowest effective dose for the shortest duration necessary to control symptoms
• Do not exceed the prescribed dose or duration without medical consultation
• Take after meals or with food to minimize gastrointestinal side effects
• Maintain adequate hydration while taking this medication

Side Effects of Acemiz Plus Tablet

Common Side Effects

• Stomach discomfort or indigestion
• Nausea or mild vomiting
• Heartburn
• Diarrhea or constipation
• Dizziness or headache
• Drowsiness or fatigue

Serious Side Effects (Seek Medical Attention)

• Severe abdominal pain or persistent discomfort
• Black or bloody stools
• Vomiting blood or coffee-ground material
• Skin rash, itching, or swelling
• Yellowing of skin or eyes (jaundice)
• Unusual tiredness or weakness
• Swelling of feet or ankles
• Shortness of breath or chest pain
• Allergic reactions including skin eruptions or anaphylaxis

How to Manage Common Side Effects

• Take with food or milk to reduce stomach irritation
• Stay well-hydrated throughout the day
• Avoid lying down immediately after taking the medication
• Use antacids if recommended by your doctor (with appropriate timing)
• Report persistent or severe side effects to your healthcare provider

Safety Advice for Acemiz Plus Tablet

Alcohol

UNSAFE: Avoid alcohol consumption while taking Acemiz Plus Tablet as it increases the risk of liver damage and gastrointestinal bleeding.

Pregnancy

UNSAFE: Not recommended during pregnancy, especially in the third trimester. May cause complications for both mother and developing fetus.

Breastfeeding

CONSULT DOCTOR: Limited safety data available. May pass into breast milk. Alternative medications might be preferred.

Driving

CAUTION: May cause dizziness, drowsiness, or visual disturbances in some individuals. Assess your response to the medication before driving or operating machinery.

Kidney Function

CAUTION: Use with caution in patients with mild to moderate kidney impairment. Not recommended in severe kidney disease. Dosage adjustments may be necessary.

Liver Function

CAUTION: Both components can affect liver function. Use with caution in patients with existing liver conditions. Regular monitoring may be necessary during long-term use.

Children

NOT RECOMMENDED: Safety and efficacy not established in children under 14 years of age.

Older Patients

CAUTION: Elderly patients may be more susceptible to side effects. Lower doses may be appropriate. Careful monitoring recommended.

Allergy

AVOID: Do not use if you have known hypersensitivity to Aceclofenac, Paracetamol, other NSAIDs, or any components of the formulation.

Warnings & Precautions

• Cardiovascular Risk: May increase risk of heart attack, stroke, or related conditions, especially with prolonged use or in patients with existing heart disease
• Gastrointestinal Effects: Can cause ulcers, bleeding, or perforation of the stomach or intestines, particularly in elderly patients or those with a history of peptic ulcer disease
• Hepatotoxicity: Regular monitoring of liver function recommended during long-term therapy
• Renal Effects: May cause kidney damage, especially in dehydrated patients or those with kidney disease
• Skin Reactions: Serious skin reactions including Stevens-Johnson syndrome have been reported rarely
• Asthma: May trigger bronchospasm in patients with aspirin-sensitive asthma
• Blood Disorders: May affect blood cell counts during prolonged use
• Surgery: Should be discontinued 5-7 days before major surgery
• Masking Symptoms: May mask signs of infection or other conditions

Interactions with Acemiz Plus Tablet

Drug Interactions

• Other NSAIDs or Aspirin: Increased risk of side effects and bleeding
• Anticoagulants (Warfarin): Enhanced anticoagulant effect with increased bleeding risk
• Antihypertensives: May reduce blood pressure-lowering effects
• Diuretics: Reduced effectiveness and increased risk of kidney problems
• Corticosteroids: Increased risk of gastrointestinal ulceration and bleeding
• Methotrexate: Increased methotrexate levels and toxicity
• Lithium: Increased blood levels of lithium, potentially leading to toxicity
• Quinolone Antibiotics: May increase risk of seizures
• Antidiabetic Medications: May affect blood glucose levels
• Alcohol: Increased risk of liver damage and gastrointestinal bleeding

Food Interactions

• High-Fat Meals: May delay absorption but typically doesn't affect overall effectiveness
• Caffeine: May enhance pain relief but could increase nervousness or restlessness
• Herbal Products: St. John's Wort, Ginkgo Biloba may increase bleeding risk

Contraindications

Acemiz Plus Tablet is contraindicated in:

• Patients with known hypersensitivity to Aceclofenac, Paracetamol, or other NSAIDs
• Active peptic ulcer disease or history of recurrent ulcers/bleeding
• Severe heart failure
• Severe liver or kidney dysfunction
• Last trimester of pregnancy
• History of asthma, urticaria, or allergic reactions triggered by aspirin or other NSAIDs
• Patients undergoing coronary artery bypass graft (CABG) surgery
• Children under 14 years of age

Safety Measures & FDA Pregnancy Category

• FDA Pregnancy Category: Category C (before 30 weeks of gestation), Category D (after 30 weeks)
• Black Box Warning: NSAIDs like Aceclofenac may increase risk of serious cardiovascular thrombotic events, myocardial infarction, stroke, and serious gastrointestinal events including bleeding, ulceration, and perforation

Diet & Lifestyle Advice

• Maintain adequate hydration while taking this medication
• Follow a balanced diet rich in fruits, vegetables, and whole grains
• Consider incorporating anti-inflammatory foods like fatty fish, olive oil, and nuts
• Apply hot or cold packs to affected areas as appropriate
• Practice gentle stretching and appropriate exercise as recommended by your healthcare provider
• Maintain a healthy weight to reduce stress on joints
• Consider stress reduction techniques like meditation, yoga, or deep breathing
• Avoid smoking as it can worsen inflammation and reduce healing
• Use proper ergonomics and body mechanics during daily activities

Why Doctors Recommend This Medicine

Healthcare providers prescribe Acemiz Plus Tablet because:

• The combination provides enhanced pain relief through dual mechanisms
• It offers better anti-inflammatory effects than many single-ingredient alternatives
• The fixed-dose combination improves patient compliance
• It has a relatively rapid onset of action
• It's effective for multiple types of pain and inflammatory conditions
• The combination allows for lower doses of each component
• It has a well-established safety profile when used appropriately
• It's suitable for various acute and chronic painful conditions

Substitutes & Alternative Medicines

Similar Combination Products

• Aceclofenac + Paracetamol + Serratiopeptidase combinations
• Diclofenac + Paracetamol combinations
• Ibuprofen + Paracetamol combinations
• Naproxen + Paracetamol combinations

Alternative Approaches

• Single-ingredient NSAIDs (Ibuprofen, Naproxen, Diclofenac)
• COX-2 specific inhibitors (Celecoxib, Etoricoxib)
• Topical analgesics and anti-inflammatory preparations
• Physical therapy and rehabilitation
• Heat/cold therapy
• Transcutaneous electrical nerve stimulation (TENS)

Note: Substitutes should only be used under medical supervision

Storage Guidelines

• Store at room temperature between 15-30°C (59-86°F)
• Protect from light and moisture
• Keep away from direct heat and sunlight
• Store in the original package or container
• Keep out of reach of children
• Do not use after the expiration date

User Feedback & Patient Concerns

Common questions and concerns about Acemiz Plus Tablet:

• How quickly will I experience pain relief?
• Can I take it for headaches or fever?
• How long can I safely take this medication?
• Will it make me drowsy or affect my ability to work?
• Can I take it with my other medications?
• What should I do if I experience stomach pain while taking it?

Quick Tips

• Always take with food or after meals to reduce stomach irritation
• Don't lie down immediately after taking the tablet
• Take only as prescribed and don't exceed recommended doses
• Don't use for longer than prescribed without medical advice
• Report any unusual side effects to your doctor promptly
• Keep track of other medications containing paracetamol to avoid overdose
• Stay well-hydrated while on this medication
• Consider complementary approaches like gentle exercise and physical therapy

Fact Box

• Chemical Class: Aceclofenac (Phenylacetic acid derivative NSAID), Paracetamol (Para-aminophenol derivative)
• Habit Forming: No
• Therapeutic Class: Analgesic and Anti-inflammatory
• Action Class: Non-steroidal Anti-inflammatory Drug (NSAID) + Non-opioid Analgesic

Useful Diagnostic Tests

Before or during treatment with Acemiz Plus Tablet, your doctor may recommend:

• Liver function tests
• Kidney function tests
• Complete blood count
• Stool occult blood test (if GI symptoms occur)
• Cardiovascular assessment in at-risk patients
• Upper GI endoscopy (if history of ulcers or persistent GI symptoms)

Disclaimer

This information is provided for educational purposes only and is not intended as a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions regarding a medical condition. Never disregard professional medical advice or delay seeking it because of something you have read in this article. If you think you may have a medical emergency, call your doctor or emergency services immediately. Individual responses to medications may vary, and not all possible side effects, interactions, precautions, or adverse effects are described here.