AF Kit Tablet – Treatment for Vaginal Discharge & Mixed Infections

AF Kit Tablet

Prescription Required

Marketer

Systopic Laboratories Pvt Ltd

SALT COMPOSITION

Azithromycin (1000mg) + Ornidazole (750mg) + Fluconazole (150mg)

Storage

Store below 30°C

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Product Introduction

AF Kit Tablet is a powerful fixed-dose combination medication containing three active ingredients: Azithromycin (1000mg), Ornidazole (750mg), and Fluconazole (150mg). This unique triple-action formulation is specifically designed to combat complex mixed infections by targeting different types of pathogens simultaneously. The combination effectively treats bacterial infections (through Azithromycin), anaerobic and protozoal infections (through Ornidazole), and fungal infections (through Fluconazole), making it a comprehensive solution for mixed infections that might not respond to single-agent therapy.

This medication represents an innovative approach to treating polymicrobial infections, which are common in certain conditions like pelvic inflammatory disease, complicated intra-abdominal infections, and certain types of sexually transmitted infections. By combining three different antimicrobial agents with complementary spectrums of activity, AF Kit Tablet provides broad coverage against diverse pathogens while simplifying the treatment regimen for patients.

The components of AF Kit work through different mechanisms: Azithromycin inhibits bacterial protein synthesis, Ornidazole disrupts DNA in anaerobic organisms, and Fluconazole interferes with fungal cell membrane formation. This multi-targeted approach not only increases the likelihood of successful treatment but also potentially reduces the development of antimicrobial resistance, which can occur when single agents are used repeatedly.

Healthcare providers may prescribe AF Kit Tablet when there is clinical suspicion of mixed infections or when empiric therapy covering multiple pathogen types is warranted. The convenience of having three antimicrobial agents in a single kit improves patient compliance compared to taking multiple separate medications.

It's important to note that AF Kit Tablet is a prescription-only medication and should be used strictly under medical supervision. As with all antimicrobial treatments, appropriate use helps maximize effectiveness while minimizing side effects and reducing the risk of developing antimicrobial resistance. The medication should never be self-prescribed or shared with others, even if they have similar symptoms, as improper use can lead to treatment failure, side effects, and contribute to the growing global concern of antimicrobial resistance.

Key Composition & Ingredients

Active Ingredients:

• Azithromycin: 1000mg - A macrolide antibiotic effective against gram-positive, gram-negative, and atypical bacteria
• Ornidazole: 750mg - A nitroimidazole derivative active against anaerobic bacteria and certain protozoa
• Fluconazole: 150mg - A triazole antifungal effective against various Candida species and other fungi

Inactive Ingredients:

May include microcrystalline cellulose, sodium starch glycolate, magnesium stearate, colloidal silicon dioxide, hydroxypropyl methylcellulose, titanium dioxide, and pharmaceutical colorants.

Uses of AF Kit Tablet

AF Kit Tablet is prescribed for treating complex mixed infections involving bacteria, anaerobes, protozoa, and fungi, including:

• Pelvic Inflammatory Disease (PID) - Infection of the female reproductive organs
• Mixed abdominal infections - Including peritonitis and intra-abdominal abscesses
• Complicated skin and soft tissue infections - Where multiple pathogens are suspected
• Certain sexually transmitted infections - Particularly those with mixed etiology
• Dental and periodontal infections - With bacterial and anaerobic components
• Post-surgical infections - Especially following gastrointestinal or gynecological procedures
• Complicated urinary tract infections - With mixed bacterial and fungal pathogens
• Bacterial vaginosis with concurrent fungal infection
• Certain respiratory tract infections - With suspected mixed pathogens

Benefits of AF Kit Tablet

• Broad-spectrum coverage against bacteria, anaerobes, protozoa, and fungi
• Simplified treatment regimen with three medications in one kit
• Improved patient compliance compared to taking multiple separate medications
• Reduced risk of treatment failure due to comprehensive pathogen coverage
• Convenient dosing schedule with once-daily or once-only dosing depending on indication
• Potentially shorter treatment duration for certain infections
• Reduced risk of secondary infections (e.g., candidiasis following antibiotic treatment)
• Synergistic action against polymicrobial infections
• Reduction in pill burden compared to taking individual medications

How AF Kit Tablet Works (Mechanism of Action)

The three components of AF Kit Tablet work through different mechanisms to provide comprehensive antimicrobial coverage:

Azithromycin (1000mg):

Azithromycin is a macrolide antibiotic that binds to the 50S subunit of bacterial ribosomes, inhibiting RNA-dependent protein synthesis. This prevents bacteria from producing essential proteins needed for their survival and growth. Azithromycin is primarily bacteriostatic (inhibits growth) but can be bactericidal (kills bacteria) at higher concentrations. It concentrates in phagocytes and fibroblasts, which transport it to infection sites, achieving tissue concentrations significantly higher than plasma concentrations.

Ornidazole (750mg):

Ornidazole is a nitroimidazole derivative that is activated by reduction of its nitro group inside anaerobic organisms. This reduced form interacts with bacterial DNA, causing strand breakage and inhibiting nucleic acid synthesis, ultimately leading to bacterial cell death. It is particularly effective against anaerobic bacteria and certain protozoa like Trichomonas, Giardia, and Entamoeba species, which thrive in oxygen-poor environments.

Fluconazole (150mg):

Fluconazole inhibits fungal cytochrome P450 enzyme, 14-alpha-demethylase, which is responsible for converting lanosterol to ergosterol, an essential component of fungal cell membranes. This disrupts membrane structure and function, making the fungal cell leaky and unable to function properly. The selective targeting of fungal enzymes over mammalian ones contributes to Fluconazole's relatively favorable safety profile.

Dosage of AF Kit Tablet

Daily Dose

The typical adult dosage regimen varies by indication:

• Pelvic Inflammatory Disease and Mixed Infections:
  • Usually prescribed as a single kit taken once daily for 1-3 days, depending on the severity and type of infection
  • For some indications, a single-day treatment may be sufficient
• Complicated Infections:
  • May require extended treatment, typically one kit daily for up to 5 days

Specific Dosing by Component:

• Azithromycin: 1000mg once daily (or as a single dose in some cases)
• Ornidazole: 750mg once daily
• Fluconazole: 150mg once daily (or as a single dose in some cases)

Missed Dose

If you miss a dose, take it as soon as you remember. However, if it's almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one.

Overdose

Symptoms of overdose may include increased side effects such as severe gastrointestinal disturbances, liver problems, heart rhythm abnormalities, and neurological symptoms. Seek immediate medical attention if overdose is suspected.

How to Use AF Kit Tablet

Directions for Use

• Take AF Kit Tablet exactly as prescribed by your doctor
• Usually taken once daily, preferably in the morning
• May be taken with or without food, but taking with food may help reduce stomach upset
• For Azithromycin: Take at least 1 hour before or 2 hours after antacids containing aluminum or magnesium
• Swallow tablets whole with a full glass of water
• Complete the full prescribed course even if symptoms improve before completion
• Take all components of the kit as directed; do not split the treatment or save portions for later use

Side Effects of AF Kit Tablet

Common Side Effects

• Nausea
• Vomiting
• Diarrhea
• Abdominal pain
• Metallic taste (particularly from Ornidazole)
• Headache
• Dizziness
• Fatigue

Serious Side Effects (Require Immediate Medical Attention)

• Severe allergic reactions (rash, itching, swelling, severe dizziness, difficulty breathing)
• Severe persistent diarrhea (may indicate C. difficile infection)
• Liver problems (yellowing of eyes/skin, dark urine, persistent nausea/vomiting, severe stomach pain)
• Heart rhythm changes (fast/irregular heartbeat, fainting)
• Severe skin reactions (Stevens-Johnson syndrome, toxic epidermal necrolysis)
• Neurological symptoms (seizures, confusion, peripheral neuropathy)
• Signs of fungal superinfection (white patches in mouth, vaginal discharge with itching)

How to Manage Side Effects

• Gastrointestinal issues: Take with food to reduce stomach upset; stay hydrated
• Metallic taste: Temporary and resolves after completion of treatment; sugar-free gum may help
• Diarrhea: Stay hydrated; consult doctor if severe or contains blood
• Headache/Dizziness: Rest; avoid sudden position changes; avoid driving if affected
• Nausea: Eat small, frequent meals; avoid spicy or rich foods
• Allergic reactions: Discontinue medication and seek immediate medical attention

Safety Advice for AF Kit Tablet

Alcohol

Avoid completely. Ornidazole can cause a disulfiram-like reaction (flushing, headache, nausea, vomiting, abdominal cramps) when combined with alcohol. Effects may occur during treatment and for up to 3 days after completing Ornidazole therapy.

Pregnancy

Not recommended. FDA Pregnancy Categories: Azithromycin (B), Ornidazole (C), Fluconazole (D). The combination poses potential risks to the fetus, particularly due to Fluconazole, which has been associated with birth defects at high doses. Use only if clearly needed and potential benefits outweigh risks, as determined by your doctor.

Breastfeeding

Not recommended. All three components pass into breast milk. Temporary discontinuation of breastfeeding during treatment and for 48-72 hours after the last dose may be advised.

Driving

Use caution. May cause dizziness, confusion, or vision changes, particularly due to Ornidazole component. Avoid driving or operating machinery until you know how this medication affects you.

Kidney Function

Use with caution. Dosage adjustment may be necessary for patients with severe kidney impairment (particularly for Fluconazole component).

Liver Function

Use with caution or avoid. All three components undergo liver metabolism. Not recommended for patients with liver disease. Regular monitoring of liver function may be necessary during treatment.

Use in Children

Not recommended for children. Safety and efficacy in pediatric populations have not been established for this combination.

Use in Older Patients

Use with caution. Elderly patients may be more sensitive to side effects, particularly QT interval prolongation (Azithromycin) and CNS effects (Ornidazole). Dosage adjustment may be necessary based on kidney and liver function.

Allergies

Contraindicated in patients with known hypersensitivity to any of the components or related drugs (macrolides, nitroimidazoles, azole antifungals).

Warnings & Precautions for AF Kit Tablet

• QT Prolongation Risk: Azithromycin may prolong the QT interval, especially in elderly patients or those with heart conditions
• Liver Function: All components can affect liver function; discontinue if signs of liver dysfunction occur
• C. difficile-Associated Diarrhea: May occur during or weeks after treatment
• Neurological Effects: Ornidazole may cause seizures, peripheral neuropathy, or confusion
• Superinfections: Prolonged use may result in secondary infections due to disruption of normal flora
• Heart Rhythm Disorders: Use with caution in patients with cardiac arrhythmias or those taking other QT-prolonging medications
• Sodium/Potassium Levels: Monitor electrolytes, particularly in patients taking medications that affect potassium levels
• Drug Interactions: Multiple potential interactions due to the three active components
• Peripheral Neuropathy: Ornidazole may cause nerve damage with prolonged use
• Blood Disorders: Monitor for signs of blood dyscrasias during treatment

Drug Interactions

Drug-Drug Interactions

Azithromycin Interactions:

• QT-prolonging medications: Increased risk of cardiac arrhythmias
• Warfarin: May increase anticoagulant effects
• Ergot derivatives: Risk of ergotism
• Digoxin: May increase digoxin levels
• Statins: Increased risk of myopathy
• Pimozide: Contraindicated due to risk of cardiac arrhythmias
• Antacids: Reduced absorption of azithromycin

Ornidazole Interactions:

• Alcohol: Disulfiram-like reaction
• Warfarin: Enhanced anticoagulant effect
• Lithium: Increased lithium levels
• Phenytoin: Increased phenytoin levels
• Fluorouracil: May increase toxicity of fluorouracil
• Cimetidine: May increase ornidazole levels

Fluconazole Interactions:

• CYP3A4 substrates: Enhanced effects of drugs metabolized by CYP3A4 (e.g., benzodiazepines, calcium channel blockers)
• Warfarin: Enhanced anticoagulant effect
• Sulfonylureas: Prolonged hypoglycemic effects
• Phenytoin: Increased phenytoin levels
• Cyclosporine: Increased cyclosporine levels
• Zidovudine: Increased zidovudine levels
• Rifampin: Decreased fluconazole levels
• QT-prolonging medications: Increased risk of QT prolongation

Drug-Food Interactions

• Food: Generally minimal effect; may take with food to reduce gastrointestinal side effects
• Grapefruit juice: May increase levels of azithromycin and fluconazole; avoid during treatment

Contraindications of AF Kit Tablet

• Known hypersensitivity to any component (azithromycin, ornidazole, fluconazole) or related drugs
• Severe liver disease
• History of QT prolongation or cardiac arrhythmias
• Pregnancy (particularly first trimester)
• Breastfeeding mothers
• Blood dyscrasias or CNS diseases (due to ornidazole component)
• Patients with G6PD deficiency (particularly due to ornidazole)
• Concomitant use with pimozide, ergot alkaloids, or other contraindicated medications
• History of cholestatic jaundice/hepatic dysfunction with prior use of any component
• First trimester of pregnancy (due to fluconazole)

Safety Measures & FDA Pregnancy Category

The FDA Pregnancy Categories for the components are:

• Azithromycin: Category B (Animal studies show no risk, but human studies inadequate)
• Ornidazole: Category C (Animal studies show adverse effects, human studies inadequate)
• Fluconazole: Category D (Evidence of human fetal risk, but benefits may outweigh risks in certain situations)

Overall, AF Kit should be avoided during pregnancy, particularly in the first trimester, due to the fluconazole component.

Diet & Lifestyle Advice

• Stay well-hydrated throughout treatment
• Complete the full course of treatment even if symptoms improve
• Avoid alcohol completely during treatment and for at least 3 days after completing treatment
• Probiotics may help minimize gastrointestinal side effects
• Avoid unprotected sexual activity during treatment for sexually transmitted infections
• Inform all healthcare providers about this medication if seeking treatment for other conditions
• Rest adequately to support recovery
• Avoid excessive sun exposure as azithromycin may increase sensitivity to sunlight
• Maintain good personal hygiene to prevent reinfection or spreading infection to others

Why Doctors Recommend This Medicine

Doctors recommend AF Kit Tablet for:

• Complex mixed infections involving multiple pathogen types
• Empiric therapy when the specific causative organism is unknown but multiple types are suspected
• Simplified treatment regimens to improve patient compliance
• Prevention of sequential infections (e.g., fungal infections following antibiotic treatment)
• Targeted therapy for specific conditions known to have polymicrobial etiology
• Reduction in pill burden for patients requiring treatment for multiple organism types
• Synergistic antimicrobial action against certain polymicrobial infections
• Broad-spectrum coverage in serious infections requiring immediate treatment before culture results

Substitutes & Alternative Medicines

Individual components may be prescribed separately or in different combinations based on specific infection types:

• For Azithromycin alternatives:
  • Other macrolides: Clarithromycin, Erythromycin
  • Fluoroquinolones: Levofloxacin, Moxifloxacin
  • Tetracyclines: Doxycycline, Minocycline
• For Ornidazole alternatives:
  • Other nitroimidazoles: Metronidazole, Tinidazole, Secnidazole
• For Fluconazole alternatives:
  • Other azole antifungals: Itraconazole, Voriconazole
  • Echinocandins: Caspofungin, Micafungin
  • Polyenes: Amphotericin B (for severe fungal infections)

Selection depends on specific infection, patient factors, and local resistance patterns.

Other Products from this Brand

• AF 400MG STRIP OF 1 TABLETS
• AF 150MG STRIP OF 1 TABLETS
• AF 200MG STRIP OF 1 TABLETS
• AF C BOTTLE OF 100GM POWDER
• AF 300MG STRIP OF 1 TABLETS

Storage Guidelines

• Store at room temperature between 59°F to 86°F (15°C to 30°C)
• Keep away from moisture, heat, and direct light
• Keep container tightly closed
• Keep out of reach of children
• Do not store in the bathroom
• Do not use after the expiration date
• Keep in original packaging until ready to use

User Feedback & Patient Concerns

Common feedback and concerns include:

• Effectiveness in treating complex mixed infections
• Gastrointestinal side effects (nausea, diarrhea) are commonly reported
• Metallic taste from ornidazole component is often reported but temporary
• Drug interactions due to multiple active ingredients
• Alcohol restrictions during and after treatment
• Convenience of combination therapy versus separate medications
• Treatment duration is generally shorter than sequential therapy with individual agents
• Cost considerations compared to separate medications

Quick Tips for AF Kit Tablet

• Take with food to minimize stomach upset
• Absolutely avoid alcohol during treatment and for 3 days after
• Complete the entire prescribed course, even if symptoms improve
• Take at the same time each day for best results
• Stay well-hydrated throughout treatment
• Report any severe or persistent side effects to your doctor immediately
• Inform all healthcare providers about this medication before starting any new treatments
• Do not share this medication with others, even if they have similar symptoms
• Use additional methods of contraception if you're taking hormonal contraceptives
• Follow up with your healthcare provider after treatment to ensure the infection has resolved

Fact Box

• Chemical Class:
  • Azithromycin: Macrolide (Azalide subclass)
  • Ornidazole: Nitroimidazole derivative
  • Fluconazole: Triazole antifungal
• Habit Forming: No
• Therapeutic Class:
  • Antimicrobial combination therapy
  • Combined antibacterial, antiprotozoal, and antifungal agent
• Action Class:
  • Protein synthesis inhibitor (Azithromycin)
  • DNA disruptor (Ornidazole)
  • Ergosterol synthesis inhibitor (Fluconazole)

Useful Diagnostic Tests

• Culture and sensitivity testing when possible before initiating therapy
• Complete blood count to monitor for blood dyscrasias
• Liver function tests before and during treatment (especially with extended use)
• Kidney function tests for patients with renal impairment
• ECG for patients with cardiac risk factors or on other QT-prolonging medications
• Specific tests based on infection site:
  • Vaginal swabs for suspected vaginitis/cervicitis
  • Stool examination for intestinal infections
  • Imaging studies for abdominal/pelvic infections

More Information & References

For more information, consult:

• American Society of Health-System Pharmacists (ASHP)
• Centers for Disease Control and Prevention (CDC) guidelines on antimicrobial use
• World Health Organization (WHO) guidelines on antimicrobial stewardship
• National Institutes of Health (NIH) MedlinePlus
• Your healthcare provider or pharmacist

Disclaimer

This information is provided for educational purposes only and is not intended as a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read here. This medicine should only be used under direct medical supervision. Self-medication can be dangerous and may mask serious underlying conditions. The information provided here may not cover all possible uses, actions, precautions, side effects, or interactions. It is not intended as medical advice for individual conditions or treatment.