Benalgis Tablet
Marketer
Franco-Indian Pharmaceuticals Pvt Ltd
SALT COMPOSITION
Benfotiamine (100mg)
Storage
Store below 25°C
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Product Introduction
Benalgis Tablet is a specialized nutritional supplement containing Benfotiamine 100mg as its active ingredient. Benfotiamine is a synthetic, fat-soluble derivative of thiamine (vitamin B1) that offers enhanced bioavailability and absorption compared to standard water-soluble thiamine supplements. This innovative formulation allows for higher blood and tissue levels of thiamine, making it particularly effective for addressing thiamine deficiency and related conditions.
Benalgis Tablet represents an advanced approach to vitamin B1 supplementation, designed to overcome the limitations of conventional thiamine supplements. The unique molecular structure of benfotiamine enables it to pass through cell membranes more efficiently, resulting in significantly higher bioavailability—up to 3.6 times greater than water-soluble thiamine supplements. This improved absorption mechanism makes Benalgis an effective intervention for conditions associated with thiamine deficiency.
Originally developed in Japan in the late 1950s, benfotiamine has gained recognition worldwide for its therapeutic potential, particularly in addressing diabetic complications and nerve-related disorders. Benalgis Tablet delivers this powerful compound in a convenient, precisely-dosed oral formulation for daily use.
For individuals with diabetes, peripheral neuropathy, or other conditions that may benefit from enhanced thiamine levels, Benalgis offers a well-tolerated option with minimal side effects. Its fat-soluble nature allows it to penetrate cell membranes and reach tissues where water-soluble forms of thiamine cannot effectively accumulate, potentially providing more comprehensive thiamine repletion throughout the body.
Benalgis Tablet is manufactured under strict quality control standards to ensure consistency and potency. As with any supplement, it should be used under appropriate medical supervision, particularly for individuals with specific health conditions or those taking multiple medications.
Key Composition & Ingredients
The primary active ingredient in Benalgis Tablet is:
- Benfotiamine 100mg (a lipid-soluble analog of thiamine/vitamin B1)
Inactive ingredients may include:
- Microcrystalline cellulose
- Calcium hydrogen phosphate
- Magnesium stearate
- Silicon dioxide
- Pharmaceutical grade excipients
- Hydroxypropyl methylcellulose (coating)
- Titanium dioxide (coloring agent)
- Talc
Uses of Benalgis Tablet
Benalgis Tablet is primarily prescribed for:
- Treatment and prevention of diabetic neuropathy
- Management of peripheral neuropathy (nerve damage)
- Addressing thiamine (vitamin B1) deficiency
- Supporting nerve health in patients with diabetes
- Relief from neuropathic pain and discomfort
- Prevention of diabetic complications
- Adjunct therapy for alcoholic neuropathy
- Supporting nerve regeneration
- Management of sciatica and other nerve-related pain
- Addressing advanced glycation end products (AGEs) accumulation
- Supporting individuals with malabsorption conditions
- Prevention of Wernicke-Korsakoff syndrome in at-risk individuals
Benefits of Benalgis Tablet
- Higher bioavailability than standard thiamine supplements
- Reduces neuropathic pain and discomfort
- Improves nerve conduction velocity in diabetic neuropathy
- Helps prevent progression of nerve damage
- Reduces numbness, tingling, and burning sensations
- Protects against vascular damage in diabetes
- May improve walking ability in patients with nerve damage
- Supports cellular energy metabolism
- Reduces accumulation of harmful metabolic byproducts
- Provides antioxidant protection to nerve tissues
- Improves quality of life for patients with neuropathy
- Well-tolerated with minimal side effects
- May help reduce dependence on pain medications
- Supports overall neurological health
How Benalgis Tablet Works (Mechanism of Action)
Benfotiamine, the active ingredient in Benalgis Tablet, works through several important mechanisms:
- Enhanced Thiamine Delivery: As a lipid-soluble derivative of thiamine, benfotiamine passes through cell membranes more efficiently than standard water-soluble thiamine. Once inside cells, benfotiamine is converted to thiamine pyrophosphate (TPP), the active coenzyme form of vitamin B1.
- Activation of Transketolase: Benfotiamine significantly increases the activity of transketolase, a critical enzyme that diverts sugar metabolites from harmful pathways to the pentose phosphate pathway. This helps reduce the formation of advanced glycation end products (AGEs) that contribute to nerve damage.
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Blocking Three Harmful Pathways: Benfotiamine inhibits three major pathways of hyperglycemic damage:
- The hexosamine pathway
- The diacylglycerol-protein kinase C pathway
- The AGE formation pathway
- Protection Against Oxidative Stress: Benfotiamine enhances antioxidant defense mechanisms, neutralizing reactive oxygen species that damage nerve cells.
- Support for Energy Metabolism: As thiamine pyrophosphate, it serves as a cofactor for key enzymes in glucose metabolism, including pyruvate dehydrogenase, alpha-ketoglutarate dehydrogenase, and transketolase. This improves cellular energy production, particularly important for energy-demanding nerve cells.
- Anti-inflammatory Effects: Benfotiamine reduces the production of pro-inflammatory cytokines and inhibits the activation of nuclear factor-kappa B (NF-κB), a key regulator of inflammation.
- Promotion of Nerve Regeneration: Benfotiamine may support the regeneration of damaged nerve fibers by improving microcirculation and providing essential nutrients for nerve repair.
These combined mechanisms make Benalgis particularly effective for addressing diabetic neuropathy and other conditions associated with thiamine deficiency or metabolic stress.
Dosage of Benalgis Tablet
Standard Adult Dose:
- For diabetic neuropathy: One tablet (100mg) two to three times daily, or as directed by healthcare provider
- For maintenance therapy: One tablet (100mg) once or twice daily
- For severe deficiency states: Up to 300-450mg daily (divided into 3 doses) for 3-6 weeks, followed by maintenance dose
Missed Dose: If a dose is missed, take it as soon as remembered unless it's nearly time for the next dose. Do not double the dose to make up for a missed dose.
Overdose: Benfotiamine has shown low toxicity even at high doses. However, if suspected overdose occurs, contact healthcare provider. Symptoms might include nausea, headache, or stomach discomfort.
Special Populations:
- Elderly patients: Standard adult dosing usually applies, but begin at lower doses if frailty or impaired kidney function is present
- Renal impairment: No specific dose adjustment typically required, but monitor carefully
- Hepatic impairment: No specific dose adjustment typically required
- Pregnancy/lactation: Should be used only if clearly needed and under medical supervision
How to Use Benalgis Tablet
- Take Benalgis Tablet exactly as prescribed by your healthcare provider
- Swallow the tablet whole with a full glass of water
- Can be taken with or without food, though absorption may be enhanced when taken with meals containing some fat
- For best results, take at approximately the same times each day to maintain consistent blood levels
- Establish a regular routine for taking the medication to help remember doses
- Do not crush or chew the tablet unless specifically instructed by your healthcare provider
- The full therapeutic effect may take several weeks to develop; continue taking as prescribed even if symptoms do not immediately improve
- Store at room temperature away from moisture and heat
- Keep track of symptom improvements to discuss with your healthcare provider
- Complete the full course of treatment as prescribed, even if symptoms improve
Side Effects of Benalgis Tablet
Common (affects less than 1 in 10 people):
- Mild gastrointestinal discomfort
- Nausea
- Feeling of warmth
Uncommon (affects less than 1 in 100 people):
- Headache
- Skin rash
- Mild allergic reactions
- Stomach upset
Rare (affects less than 1 in 1,000 people):
- Severe allergic reactions
- Significant skin reactions
- Hypotension (low blood pressure)
Management of Side Effects:
- Gastrointestinal discomfort can often be reduced by taking with food
- Temporary headaches typically resolve without intervention
- For skin rash, discontinue use and consult healthcare provider
- For allergic reactions, seek medical attention immediately
- If experiencing any unusual or severe side effects, consult your healthcare provider
Benfotiamine is generally well-tolerated, with a favorable safety profile compared to many medications used for neuropathy. Most side effects, if they occur, are mild and transient.
Safety Advice for Benalgis Tablet
Alcohol: Avoid excessive alcohol consumption as it impairs thiamine absorption and utilization, potentially reducing effectiveness of treatment.
Pregnancy: Limited data available. Use only if clearly needed and potential benefits outweigh risks. Discuss with healthcare provider. Generally considered Pregnancy Category C (animal studies have shown adverse effects; no adequate human studies).
Breastfeeding: Limited data available. Use caution and consult healthcare provider before use during breastfeeding.
Driving: Generally no restrictions, as benfotiamine does not cause drowsiness or impair cognitive function. However, if experiencing side effects like dizziness, avoid driving until resolved.
Kidney: Generally safe in kidney disease, but consult healthcare provider in severe renal impairment.
Liver: Generally safe in liver disease, but consult healthcare provider in severe hepatic impairment.
Children: Safety and efficacy not established in children. Use only under medical supervision and if clearly indicated.
Older Patients: Standard adult dosing usually applies. Start at lower doses if frailty or kidney function impairment is present.
Allergy: Contraindicated in individuals with known hypersensitivity to benfotiamine, thiamine, or any components of the formulation.
Warnings & Precautions for Benalgis Tablet
- Individuals with known hypersensitivity to thiamine or benfotiamine should avoid this medication
- While rare, allergic reactions can occur; seek immediate medical attention if experiencing rash, itching, swelling, severe dizziness, or trouble breathing
- Not a replacement for proper diabetes management; continue monitoring blood glucose and following prescribed diabetes treatment
- May interact with certain medications; inform healthcare provider about all medications being taken
- Not a substitute for a balanced diet; should be used as part of a comprehensive nutrition plan
- Regular medical follow-up is important to assess effectiveness and adjust dosage if needed
- If taking for diabetic neuropathy, maintain regular foot examinations and proper foot care
- Consult healthcare provider before use if pregnant, planning pregnancy, or breastfeeding
- For individuals with alcohol dependence, benfotiamine alone may not prevent all thiamine deficiency complications; comprehensive treatment approach is needed
- If symptoms worsen or do not improve after several weeks, consult healthcare provider
Interactions with Benalgis Tablet
Drug Interactions:
- Diuretics: May increase thiamine excretion
- Digoxin: Theoretical interaction, monitor if used together
- 5-Fluorouracil: May antagonize effects of benfotiamine
- Loop diuretics (furosemide): May increase thiamine excretion
- Phenytoin: May lower thiamine levels
Food Interactions:
- High-fat meals may enhance absorption
- Coffee and tea contain anti-thiamine factors that might theoretically reduce effectiveness
- Raw fish, shellfish, and some fermented foods contain thiaminase enzymes that can break down thiamine
- Generally well-absorbed regardless of food intake
- Alcohol significantly impairs thiamine absorption and utilization
While benfotiamine has fewer interactions than many medications, always inform your healthcare provider about all supplements and medications you are taking.
Contraindications of Benalgis Tablet
Benalgis Tablet is contraindicated in:
- Patients with known hypersensitivity to benfotiamine, thiamine, or any components of the formulation
- Rare genetic conditions affecting thiamine metabolism (consult specialist)
Relative contraindications (use with caution):
- Severe renal or hepatic impairment (limited data available)
- Pregnancy and lactation (unless clearly needed)
- Children (limited data on safety and efficacy)
Diet & Lifestyle Advice
- Follow a balanced diet rich in B vitamins (whole grains, legumes, nuts, seeds, lean meat)
- For diabetic patients, maintain strict glycemic control to prevent further nerve damage
- Regular moderate exercise improves circulation and may enhance nerve function
- Stay well-hydrated to support overall metabolic function
- Limit alcohol consumption as it interferes with thiamine absorption and utilization
- Avoid excessive consumption of tea, coffee, and raw shellfish which may contain anti-thiamine factors
- For diabetic neuropathy patients, practice proper foot care and conduct regular foot examinations
- Maintain healthy weight to reduce pressure on peripheral nerves
- Consider stress reduction techniques as stress can exacerbate neuropathic symptoms
- For nerve health, include foods rich in antioxidants (colorful fruits and vegetables)
- Ensure adequate intake of other B vitamins which work synergistically with thiamine
- Avoid smoking as it impairs circulation and can worsen neuropathy
Why Doctors Recommend This Medicine
Healthcare providers prescribe Benalgis Tablet because:
- It offers superior bioavailability compared to standard thiamine supplements
- It effectively addresses diabetic neuropathy symptoms with minimal side effects
- The fat-soluble nature allows it to reach tissues inaccessible to standard thiamine
- It helps prevent progression of nerve damage in diabetic and alcoholic neuropathy
- It reduces dependence on pain medications which often have significant side effects
- It addresses the underlying metabolic pathways contributing to nerve damage
- It provides antioxidant protection to nerve tissues
- It supports cellular energy metabolism in nerve cells
- Long-term treatment has shown good safety profile
- It may help improve quality of life in patients with chronic neuropathic conditions
- It can be effectively combined with other neuropathy treatments
Substitutes of Benalgis Tablet & Alternative Medicines
Similar benfotiamine products:
- Benfonerv tablets/capsules
- Milgamma-N (combination with vitamin B6 and B12)
- Neurobion Forte (combination B vitamins)
- Thianerv (benfotiamine formulations)
Alternative approaches:
- Alpha-lipoic acid supplements (another antioxidant for neuropathy)
- Standard thiamine (vitamin B1) supplements (less bioavailable)
- B-complex vitamins
- Methylcobalamin (vitamin B12) for neuropathy
- Acetyl-L-carnitine supplements
- Gamma-linolenic acid (evening primrose oil)
- Capsaicin cream (topical application for neuropathic pain)
- Prescription medications for neuropathic pain (gabapentin, pregabalin, duloxetine)
- Transcutaneous electrical nerve stimulation (TENS)
- Acupuncture for pain management
Storage Guidelines
- Store at room temperature between 15-30°C (59-86°F)
- Keep away from direct sunlight and heat
- Store in a dry place; avoid bathroom medicine cabinets due to humidity
- Keep the container tightly closed when not in use
- Keep out of reach of children
- Do not use after the expiration date printed on the package
- Store in original packaging to protect from moisture
- Do not transfer to other containers unless specifically designed for supplements
- Avoid storing near strong-smelling substances as benfotiamine may absorb odors
User Feedback & Patient Concerns
Most patients report:
- Gradual improvement in neuropathic symptoms over several weeks
- Reduced tingling and burning sensations in extremities
- Improved sensation and reduced numbness
- Enhanced walking comfort and stability
- Better sleep due to reduced nighttime discomfort
- Minimal side effects compared to prescription pain medications
Common concerns include:
- Time to onset of benefits (typically several weeks)
- Questions about optimal dosing and duration
- Whether to continue once symptoms improve
- Cost considerations for long-term therapy
- Interactions with diabetes medications
- Whether higher doses provide additional benefits
- Questions about combining with other supplements
Quick Tips for Benalgis Tablet
- Take consistently at the same times each day for best results
- Allow 2-6 weeks to experience full therapeutic effects
- Take with meals containing some fat for optimal absorption
- Continue regular blood glucose monitoring if diabetic
- Keep a symptom journal to track improvements
- Don't stop suddenly once improvement occurs; consult healthcare provider
- Combine with proper foot care if taking for diabetic neuropathy
- Store properly to maintain potency
- Be patient - nerve healing and regeneration take time
- Report any unusual side effects to your healthcare provider
Fact Box
Chemical Class: Thiamine derivative (lipid-soluble analog of vitamin B1) Habit Forming: No Therapeutic Class: Vitamin B1 analog, Neuroprotective agent Action Class: Metabolic enhancer, Anti-AGE (Advanced Glycation End products) agent FDA Pregnancy Category: C (animal studies show adverse effects; no adequate human studies)
Useful Diagnostic Tests
- Thiamine blood levels (before and during treatment)
- Nerve conduction studies (to monitor neuropathy progression)
- Vibration perception threshold testing
- Monofilament testing for peripheral sensation
- Quantitative sensory testing
- Blood glucose monitoring for diabetic patients
- HbA1c levels (for diabetic patients)
- Transketolase activity testing (specialized)
- Electromyography (in selected cases)
- Visual analog pain scale assessments
More Information & References
Benfotiamine represents an important advancement in thiamine supplementation, particularly for conditions like diabetic neuropathy where standard water-soluble thiamine has limited effectiveness. Its unique molecular structure allows it to achieve higher bioavailability and tissue penetration.
Clinical studies have demonstrated that benfotiamine can reduce neuropathic pain, improve nerve conduction velocity, and potentially slow the progression of diabetic neuropathy. Research also suggests it may have applications in Alzheimer's disease, vascular health, and other conditions associated with carbonyl stress and advanced glycation end products.
The typical therapeutic course involves higher initial doses followed by maintenance therapy. Many patients report gradual improvement over several weeks, with optimal results often seen after 2-3 months of consistent use.
Disclaimer
The information provided is for educational purposes only and should not replace professional medical advice. Always consult your healthcare provider before starting, stopping, or changing any medication or supplement regimen. Individual responses to supplements may vary. This product should be used only as directed by a healthcare professional. Follow-up with your healthcare provider regularly when using this supplement, particularly if you have diabetes, peripheral neuropathy, or other chronic health conditions.
"Benalgis Tablet – Vitamin B-complex supplement for nutritional deficiencies. Available online at RXDawa."
Benalgis Tablet – Vitamin B Supplement for Nutritional Deficiencies | Buy Online at RXDawa