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Bilasure 20 Tablet – Anti-Allergy Medicine for Nasal & Skin Relief

Bilasure 20 Tablet

Prescription Required

Marketer

Sun Pharmaceutical Industries Ltd

SALT COMPOSITION

Bilastine (20mg)

Storage

Store below 30°C

Click here to view all substitutes

Product Introduction

Bilasure 20 Tablet contains Bilastine, a potent second-generation non-sedating antihistamine designed for the effective treatment of allergic conditions. Each tablet contains 20mg of Bilastine, which represents the standard therapeutic dose for adults and adolescents over 12 years of age.

Bilastine belongs to the piperidine class of antihistamines and was specifically developed to provide powerful relief from allergic symptoms while minimizing the sedative effects commonly associated with older antihistamines. Unlike first-generation antihistamines, Bilastine does not readily cross the blood-brain barrier, resulting in significantly reduced drowsiness and cognitive impairment when used at recommended doses.

This medication works by selectively blocking H1 histamine receptors, effectively inhibiting the inflammatory response triggered by allergen exposure. By preventing histamine from binding to these receptors, Bilastine reduces symptoms such as sneezing, itching, runny nose, watery eyes, and allergic skin reactions.

Bilasure 20 is primarily indicated for the symptomatic treatment of allergic rhinoconjunctivitis (both seasonal and perennial) and urticaria (hives). Its rapid onset of action provides relief within an hour of administration, and its extended duration of effect allows for convenient once-daily dosing.

The pharmacokinetic profile of Bilastine is favorable, with minimal metabolism in the body and primary elimination through the kidneys unchanged. This reduces the potential for drug interactions and makes it suitable for many patients, including those with liver impairment. However, like most antihistamines, Bilasure 20 should be taken on an empty stomach to ensure optimal absorption.

Bilasure 20 offers an excellent safety profile with minimal anticholinergic effects and no significant impact on cardiac function at therapeutic doses. Clinical studies have demonstrated that Bilastine 20mg provides comparable efficacy to other second-generation antihistamines while maintaining a favorable side effect profile, particularly regarding sedation and impact on psychomotor performance.

For patients seeking effective allergy relief without compromising daily functioning, alertness, or quality of life, Bilasure 20 presents a valuable therapeutic option that balances potent symptom control with minimal central nervous system effects.

Key Composition & Ingredients

  • Bilastine (20mg): The active pharmaceutical ingredient, a second-generation non-sedating H1-antihistamine
  • Inactive ingredients may include microcrystalline cellulose, sodium starch glycolate, silicon dioxide, magnesium stearate, and film coating materials

Uses of Bilasure Tablet

  • Symptomatic treatment of allergic rhinoconjunctivitis (seasonal allergies)
  • Management of perennial allergic rhinitis
  • Relief of symptoms associated with urticaria (hives)
  • Treatment of allergic conjunctivitis
  • Management of allergic skin reactions
  • Relief from hay fever symptoms
  • Treatment of dust mite allergies
  • Management of pet dander allergies

Benefits of Bilasure Tablet

  • Non-sedating formula that doesn't impair daily activities
  • Once-daily dosing improves convenience and compliance
  • Rapid onset of action (within 1 hour)
  • Long duration of effect (24+ hours)
  • Minimal drug interactions due to limited metabolism
  • Can be taken long-term without developing tolerance
  • Not associated with cardiac side effects at therapeutic doses
  • Effectively relieves multiple allergy symptoms (nasal, ocular, cutaneous)
  • Improves quality of life during allergy seasons
  • No adaptation of dose required for elderly patients or those with renal or hepatic impairment

How Bilasure Tablet Works

How the Drug Works (Mechanism of Action)

Bilastine works as a selective histamine H1-receptor antagonist with the following mechanisms:

  • Competitively and selectively binds to peripheral H1 histamine receptors
  • Prevents histamine from binding to these receptors and initiating allergic responses
  • Blocks the physiological effects of histamine release during allergic reactions
  • Inhibits histamine-mediated inflammatory cascades
  • Reduces capillary permeability, tissue edema, and mucus secretion
  • Prevents the stimulation of sensory nerve endings that cause itching and irritation
  • Does not significantly penetrate the blood-brain barrier, minimizing sedation
  • Has no affinity for muscarinic receptors, minimizing anticholinergic side effects
  • Shows no significant binding to other receptor types, reducing unwanted effects

Unlike some other antihistamines, Bilastine undergoes minimal metabolism in the body and is eliminated primarily unchanged via the kidneys and feces.

Dosage of Bilasure Tablet

Dosage (Daily Dose, Missed Dose, Overdose)

Standard Adult Dosage:

  • One tablet (20mg) once daily
  • Take at least 1 hour before or 2 hours after food intake

Adolescents (12 years and older):

  • Same as adult dosing: One tablet (20mg) once daily

Elderly Patients:

  • No dose adjustment necessary

Missed Dose:

  • Take as soon as remembered, unless it's almost time for the next dose
  • Do not take a double dose to make up for a missed dose
  • Resume regular dosing schedule

Overdose:

  • Symptoms may include headache, drowsiness, and rapid heartbeat
  • No specific antidote is known
  • Seek immediate medical attention if overdose is suspected
  • Treatment is mainly supportive and symptomatic

Mode of Action of Bilasure Tablet

Bilastine acts as a potent, highly selective histamine H1-receptor antagonist. When allergens enter the body, they trigger the release of histamine from mast cells and basophils. This histamine would normally bind to H1 receptors, causing the typical symptoms of allergic reactions, including inflammation, itching, swelling, and mucus production.

Bilastine competitively blocks these H1 receptors, preventing histamine from binding and initiating the allergic cascade. By blocking histamine's effects, Bilastine effectively reduces nasal congestion, sneezing, itchy eyes, runny nose, and other allergy symptoms.

Importantly, Bilastine has a high affinity for peripheral H1 receptors but does not readily cross the blood-brain barrier, resulting in minimal central nervous system effects. This explains its favorable non-sedating profile compared to older antihistamines.

How to Use Bilasure Tablet

Directions for Use

  • Take exactly as prescribed by your healthcare provider
  • Swallow the tablet whole with a glass of water
  • Take on an empty stomach, at least 1 hour before or 2 hours after meals
  • For best results, take at the same time each day
  • Do not take with grapefruit juice, as it may affect the absorption
  • Wait at least 1 hour before or after taking antacids or medications containing calcium, magnesium, or aluminum
  • If treating seasonal allergies, try to take regularly during the entire season
  • Complete the full course of treatment even if symptoms improve

Side Effects of Bilasure Tablet

Side Effects & How to Manage Them

Common Side Effects:

  • Headache (usually mild and transient, can be managed with appropriate pain relievers)
  • Drowsiness (affects a small percentage of users, avoid driving until effect is known)
  • Fatigue (ensure adequate rest and avoid alcohol)
  • Mild gastrointestinal disturbances (take with small amount of water)

Less Common Side Effects:

  • Increased appetite
  • Dizziness
  • Ear pain
  • Vertigo
  • Palpitations
  • Dry mouth (sip water frequently, chew sugar-free gum)
  • Abdominal discomfort
  • Elevated liver enzymes

Serious Side Effects (Seek medical attention immediately):

  • Severe allergic reactions (rash, itching, swelling, severe dizziness)
  • Irregular heartbeat
  • Shortness of breath
  • Unusual tiredness or weakness

Safety Advice for Bilasure Tablet

Alcohol: Avoid alcohol as it may increase the risk of drowsiness and dizziness.

Pregnancy: Generally not recommended unless clearly necessary. Category B - Animal studies show no risk but human studies inadequate.

Breastfeeding: Not recommended during breastfeeding. Alternative feeding methods should be considered.

Driving: May cause drowsiness in some patients. Avoid driving until you know how the medicine affects you.

Kidney: Use with caution in patients with severe renal impairment. May require dose adjustment.

Liver: Generally safe in mild to moderate liver disease. Use with caution in severe hepatic impairment.

Children: Not recommended for children under 12 years of age.

Older Patients: No dose adjustment required in elderly patients with normal kidney function.

Lactation: Not recommended during breastfeeding.

Allergy: Contraindicated in patients with known hypersensitivity to bilastine or any component of the formulation.

Warnings & Precautions of Bilasure Tablet

  • Take on an empty stomach for optimal absorption
  • Avoid using with other medications that can cause sedation
  • Not recommended for children under 12 years
  • Use caution if you have a history of QT interval prolongation
  • May cause false negative results in allergy skin tests if not discontinued 5 days prior
  • Use with caution in patients with severe renal impairment
  • Use with caution if you have epilepsy or seizure risk
  • Not recommended during pregnancy or breastfeeding
  • May cause mild drowsiness in some patients despite being considered non-sedating
  • Avoid taking with grapefruit juice which may increase drug levels

Interactions with Bilasure Tablet

Drug-Drug & Drug-Food Interactions

Drug Interactions:

  • P-glycoprotein inhibitors (ketoconazole, erythromycin, diltiazem): May increase bilastine levels
  • CNS depressants: May enhance sedative effects
  • Anticonvulsants: May reduce bilastine effectiveness
  • QT-prolonging medications: Caution advised due to potential additive effects
  • Anticholinergics: Potential increased risk of anticholinergic effects
  • Antivirals (ritonavir): May increase bilastine levels

Food Interactions:

  • Food reduces absorption significantly (take on empty stomach)
  • Grapefruit juice inhibits intestinal transporters and may increase drug levels
  • Avoid taking with meals or fruit juices

Contraindications of Bilasure Tablet

  • Hypersensitivity to bilastine or any component of the formulation
  • Severe renal impairment with creatinine clearance <30 ml/min
  • Children under 12 years of age
  • Patients with rare hereditary problems of galactose intolerance
  • Concomitant use with potent P-glycoprotein inhibitors in patients with moderate to severe renal impairment
  • Known QT interval prolongation or use with other drugs known to prolong QT interval

Safety Measures & FDA Pregnancy Category

  • FDA Pregnancy Category B: Animal studies show no risk but human studies inadequate
  • Regular monitoring advised when using in patients with renal impairment
  • Not recommended for use during pregnancy unless clearly necessary
  • ECG monitoring may be considered when used in patients with cardiac risk factors
  • Avoid use in patients with known QT interval prolongation
  • Discontinue 5 days before allergy skin testing to avoid false negative results

Diet & Lifestyle Advice

  • Take on an empty stomach for optimal absorption
  • Identify and avoid known allergens when possible
  • Keep windows closed during high pollen seasons
  • Use air purifiers in living spaces
  • Shower after outdoor activities during peak allergy seasons
  • Wash bedding regularly in hot water to reduce allergen load
  • Consider nasal saline irrigation to remove allergens
  • Stay hydrated to help thin mucus secretions
  • Wear sunglasses outdoors to protect eyes from allergens
  • Monitor local pollen counts and plan activities accordingly

Why Doctors Recommend This Medicine

Healthcare providers prescribe Bilasure 20 Tablet because:

  • It provides effective relief from allergic symptoms
  • It has minimal sedative effects compared to older antihistamines
  • Once-daily dosing improves patient compliance
  • It has a favorable safety profile with minimal drug interactions
  • It does not significantly impair cognitive or psychomotor function
  • It can be used long-term without developing tolerance
  • It's suitable for patients who need to remain alert during the day
  • It effectively treats both seasonal and perennial allergies
  • It addresses multiple allergic symptoms (nasal, ocular, cutaneous)
  • It has a rapid onset of action for prompt relief

Substitutes of Bilasure Tablet & Alternative Medicines

Alternative second-generation antihistamines include:

  • Allegra (Fexofenadine)
  • Zyrtec (Cetirizine)
  • Claritin (Loratadine)
  • Xyzal (Levocetirizine)
  • Aerius (Desloratadine)

Other branded formulations of Bilastine include:

  • Bilaxten
  • Biladay
  • Bilastad
  • Allernon
  • Bilazin

Storage Guidelines

  • Store at room temperature between 15-30°C (59-86°F)
  • Keep away from direct sunlight and moisture
  • Keep in the original package until ready to use
  • Store in a dry place
  • Keep out of reach of children
  • Do not use after the expiration date
  • Do not store in the bathroom or near sinks

User Feedback & Patient Concerns

Common patient questions include:

  • How quickly will I notice improvement in my symptoms?
  • Can I take this medication long-term?
  • Will it make me drowsy or affect my ability to drive?
  • Can I take it with my other medications?
  • Why do I need to take it on an empty stomach?
  • How does this compare to other antihistamines I've taken?
  • Will I develop tolerance over time?
  • Can I take this medication during pregnancy?

Quick Tips for Bilasure Tablet

  • Take on an empty stomach for best absorption
  • Allow at least 1 hour before or 2 hours after meals
  • Avoid grapefruit juice while taking this medication
  • Best taken in the morning for all-day protection
  • Do not crush or chew the tablet
  • May need to be taken for several days to reach full effectiveness
  • Continue regular use during allergy season even when symptoms improve
  • Consult your doctor before taking with other medications
  • Keep a record of symptom improvements to discuss with your doctor

Fact Box

Chemical Class: Piperidine derivative antihistamine

Habit Forming: No

Therapeutic Class: Second-generation H1-antihistamine

Action Class: Selective histamine H1-receptor antagonist

Useful Diagnostic Tests

Before or during treatment, the following tests may be recommended:

  • Allergy skin testing (discontinue 5 days before testing)
  • IgE blood tests
  • Complete blood count
  • Liver function tests
  • Kidney function tests
  • ECG in patients with cardiac risk factors

More Information & References

For more information, consult reputable medical resources such as:

  • World Allergy Organization guidelines
  • European Academy of Allergy and Clinical Immunology
  • American Academy of Allergy, Asthma & Immunology
  • British Society for Allergy and Clinical Immunology
  • Research articles in the Journal of Allergy and Clinical Immunology

Disclaimer

This information is for educational purposes only and not a substitute for professional medical advice. Always consult your healthcare provider before starting or changing any medication regimen. Individual responses to medication may vary. The recommended dosage may be adjusted based on individual patient factors, concurrent medical conditions, and potential drug interactions.

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