Bio-D3 Plus Calcium & Calcitriol Soft Gelatin Capsule: Uses Dosage Side Effects Benefits Price Substitutes

Bio-D3 Plus Calcium & Calcitriol Soft Gelatin Capsule

Prescription Required

Marketer

Macleods Pharmaceuticals Pvt Ltd

SALT COMPOSITION

Calcium (200mg) + Vitamin D3 (0.25mcg)

Storage

Store below 25°C

Buynow

Product Introduction

Bio-D3 Plus Calcium & Calcitriol Soft Gelatin Capsule represents an advanced nutritional supplement designed to address calcium and vitamin D deficiencies that are increasingly prevalent in our modern society. This innovative formulation combines elemental calcium (200mg) with the highly bioactive form of vitamin D, calcitriol (0.25mcg), in an easily absorbable soft gelatin capsule delivery system.

The unique combination of calcium and calcitriol in Bio-D3 Plus works synergistically to support optimal bone health and calcium metabolism. While calcium serves as the fundamental building block for bone structure, calcitriol—the active form of vitamin D3—enhances calcium absorption from the intestines and helps maintain proper calcium levels in the bloodstream. This dual-action approach makes Bio-D3 Plus particularly valuable for individuals at risk of osteoporosis, osteomalacia, and other bone density disorders.

Calcium deficiency remains a significant public health concern, affecting people of all ages but particularly postmenopausal women, older adults, and those with limited dairy intake. Meanwhile, vitamin D insufficiency has reached epidemic proportions globally, with indoor lifestyles and sun avoidance contributing to widespread deficiencies. Bio-D3 Plus addresses both these nutritional gaps in a single, convenient supplement.

The soft gelatin capsule format of Bio-D3 Plus offers several advantages over traditional tablets, including enhanced absorption, easier swallowing, and protection of the nutrients from environmental degradation. This formulation ensures that the body can efficiently utilize the calcium and calcitriol to support not only skeletal health but also proper muscle function, nerve transmission, and various cellular processes.

Healthcare providers often recommend Bio-D3 Plus for patients who need more than just nutritional support—including those recovering from fractures, individuals with malabsorption disorders, patients on long-term steroid therapy, and those with chronic kidney disease who cannot properly activate vitamin D. The precision dosing of calcitriol (0.25mcg) provides therapeutic benefits while minimizing the risk of vitamin D toxicity with proper use.

While dietary sources and sunlight exposure remain the preferred natural sources of calcium and vitamin D, Bio-D3 Plus offers a reliable supplementation option when these natural sources are insufficient. With regular use as directed by healthcare professionals, Bio-D3 Plus supports the maintenance of strong bones and overall skeletal health throughout the various stages of life.

Key Composition & Ingredients

• Active Ingredients:
  • Calcium: 200mg (as calcium carbonate)
  • Calcitriol (active form of Vitamin D3): 0.25mcg (0.25 micrograms)
• Inactive Ingredients:
  • Soybean oil
  • Gelatin (soft gel capsule)
  • Glycerin
  • Purified water
  • Vegetable oil
  • Butylated hydroxyanisole (BHA) as preservative
  • Yellow beeswax
  • Lecithin
  • Titanium dioxide (colorant)

Uses of Bio-D3 Plus Capsule

• Prevention and treatment of calcium and vitamin D deficiency
• Management of osteoporosis and osteomalacia
• Support for postmenopausal women at risk of bone loss
• Adjunctive therapy for patients on long-term corticosteroid treatment
• Management of hypocalcemia in chronic kidney disease
• Support for bone health in elderly individuals
• Prevention of rickets in children with absorption disorders
• Supportive therapy during fracture healing
• Management of hypoparathyroidism
• Prevention of calcium deficiency during pregnancy and lactation

Benefits of Bio-D3 Plus Capsule

• Promotes optimal bone mineralization and density
• Enhances calcium absorption in the intestines
• Helps maintain adequate blood calcium levels
• Reduces risk of osteoporotic fractures
• Supports proper muscle function and nerve transmission
• May help reduce muscle cramps and weakness
• Provides calcitriol, which is immediately bioavailable without requiring kidney activation
• Soft gelatin capsule format ensures better absorption
• Supports dental health and tooth strength
• May help reduce symptoms of vitamin D deficiency including fatigue and muscle pain
• Supports immune system function
• May help improve mood and cognitive function

How Bio-D3 Plus Capsule Works (Mechanism of Action)

Bio-D3 Plus works through a dual mechanism involving both calcium supplementation and the active form of vitamin D:

1. Calcium Component (200mg):
   • Directly increases calcium availability in the bloodstream
   • Serves as building material for bone matrix
   • Helps maintain calcium homeostasis in the body
   • Supports neuromuscular junction function
   • Participates in blood clotting processes
2. Calcitriol Component (0.25mcg):
   • As the active form of vitamin D3 (1,25-dihydroxycholecalciferol), calcitriol:
   • Increases intestinal absorption of calcium by upregulating calcium transport proteins
   • Promotes reabsorption of calcium in the kidneys, reducing urinary calcium loss
   • Activates osteoblasts (bone-building cells) while regulating osteoclasts (bone-resorbing cells)
   • Enhances phosphorus absorption, another critical mineral for bone health
   • Directly regulates gene expression in various tissues through vitamin D receptors
   • Provides immediate biological activity without requiring activation in the liver and kidneys

The synergistic action of these components ensures optimal calcium metabolism and utilization throughout the body.

Dosage of Bio-D3 Plus Capsule

Daily Dose

• Adults and children over 12 years: Typically one capsule daily or as directed by healthcare provider
• Postmenopausal women: May require one capsule twice daily
• Osteoporosis therapy: Dosage determined by physician based on severity
• Chronic kidney disease: Highly individualized dosing under strict medical supervision

Missed Dose

• Take as soon as remembered if within 12 hours
• Skip the missed dose if it's almost time for the next scheduled dose
• Never take double doses to compensate for missed doses
• Return to regular dosing schedule

Overdose

• Seek immediate medical attention if overdose is suspected
• Symptoms may include nausea, vomiting, confusion, weakness, constipation
• Severe overdose may lead to hypercalcemia, which can cause kidney stones and calcification of soft tissues
• Emergency treatment may include IV fluids, loop diuretics, and corticosteroids

How to Use Bio-D3 Plus Capsule

• Swallow the soft gelatin capsule whole with a full glass of water
• Can be taken with or without food, though taking with food may enhance calcium absorption
• Best taken at the same time each day to maintain consistent blood levels
• Do not break, crush, or chew the capsule
• Store properly according to package instructions
• Maintain adequate fluid intake while taking this supplement
• Follow your healthcare provider's instructions regarding duration of use
• Regular blood calcium monitoring may be recommended during long-term use

Side Effects of Bio-D3 Plus Capsule

Common Side Effects

• Mild gastrointestinal discomfort
• Constipation
• Nausea
• Bloating or gas
• Dry mouth
• Metallic taste

Serious Side Effects (Require Immediate Medical Attention)

• Signs of hypercalcemia (excessive calcium in blood): confusion, extreme thirst, frequent urination, fatigue
• Kidney stones
• Allergic reactions: rash, itching, swelling, severe dizziness, trouble breathing
• Irregular heartbeat
• Persistent headache
• Severe stomach pain or vomiting
• Mental/mood changes

How to Manage Side Effects

• For constipation: Increase fluid intake, dietary fiber, and physical activity
• For digestive discomfort: Take with meals
• For dry mouth: Stay well hydrated, use sugar-free gum or candy
• Monitor for signs of calcium excess and report to doctor
• Regular blood tests to monitor calcium and vitamin D levels during treatment

Safety Advice for Bio-D3 Plus Capsule

Alcohol

• CAUTION: May affect calcium absorption; moderate consumption recommended

Pregnancy

• SAFE IF PRESCRIBED: Use only at doses recommended by obstetrician

Breastfeeding

• SAFE IF PRESCRIBED: Generally considered safe; follow healthcare provider's guidance

Driving

• SAFE: No known effects on ability to drive or operate machinery

Kidney

• CAUTION: Requires close monitoring in kidney disease; dose adjustment may be necessary

Liver

• CAUTION: Moderate to severe liver disease may affect vitamin D metabolism

Children

• CONSULT DOCTOR: Not typically prescribed for children under 12 unless specifically indicated

Older Patients

• SAFE IF PRESCRIBED: Often beneficial but may require adjusted dosing and monitoring

Allergy

• AVOID: Do not use if allergic to any ingredients, including soy or gelatin in the capsule

Warnings & Precautions for Bio-D3 Plus Capsule

• Not suitable for patients with hypercalcemia or vitamin D toxicity
• Use with caution in patients with history of kidney stones
• Regular monitoring of serum calcium levels recommended during therapy
• May interact with certain medications (see interaction section)
• Use cautiously in patients with sarcoidosis, histoplasmosis, or other granulomatous disorders
• Excessive use may lead to hypercalcemia and associated complications
• May affect laboratory test results for PTH and vitamin D levels
• Patients with malabsorption syndromes may require special monitoring
• Dietary calcium intake should be assessed before supplementation
• Individuals with parathyroid disorders need close medical supervision

Interactions with Bio-D3 Plus Capsule

Drug-Drug Interactions

• Thiazide diuretics: May increase risk of hypercalcemia
• Digoxin: Increased calcium may enhance digoxin toxicity
• Bisphosphonates: Calcium may reduce absorption; separate administration by at least 2 hours
• Levothyroxine: Calcium may reduce absorption; separate by at least 4 hours
• Quinolone antibiotics: Calcium may reduce absorption; separate by at least 2 hours
• Tetracycline antibiotics: Calcium may reduce absorption; separate by at least 2-3 hours
• Glucocorticoids: May reduce calcium absorption
• Anticonvulsants: May accelerate vitamin D metabolism
• Cholestyramine: May reduce absorption of vitamin D
• Mineral oil: May reduce absorption of vitamin D

Drug-Food Interactions

• Oxalate-rich foods (spinach, rhubarb): May reduce calcium absorption
• Phytate-rich foods (whole grains, legumes): May decrease calcium absorption
• High sodium intake: May increase urinary calcium excretion
• Excessive caffeine: May negatively impact calcium balance
• High-fiber foods: May slightly reduce calcium absorption when taken simultaneously

Contraindications of Bio-D3 Plus Capsule

• Hypercalcemia (high blood calcium levels)
• Vitamin D toxicity
• Severe renal impairment (except under specialist guidance)
• Renal osteodystrophy with hyperphosphatemia
• Known hypersensitivity to any ingredient in the formulation
• Severe hypercalciuria (excessive calcium in urine)
• Calcium-containing kidney stones (unless under close medical supervision)
• Sarcoidosis or other granulomatous diseases (relative contraindication)
• Primary hyperparathyroidism
• Malignancies associated with hypercalcemia

Diet & Lifestyle Advice

• Maintain a balanced diet rich in natural calcium sources (dairy, leafy greens, fortified foods)
• Ensure adequate but safe sun exposure for natural vitamin D production
• Stay physically active with weight-bearing exercises to support bone health
• Limit caffeine, alcohol, and tobacco use, which can affect calcium balance
• Maintain adequate protein intake to support bone matrix formation
• Ensure sufficient magnesium intake for optimal calcium utilization
• Limit sodium intake, as excess sodium increases calcium excretion
• Stay well-hydrated to prevent kidney stone formation
• Consider bone density testing as recommended by your healthcare provider
• Follow a routine exercise program that includes resistance training

Why Doctors Recommend This Medicine

Doctors prescribe Bio-D3 Plus because:

• It combines calcium with the active form of vitamin D for enhanced absorption
• The soft gelatin capsule format improves bioavailability
• It provides precise dosing of calcitriol without requiring kidney activation
• It's beneficial for patients with impaired vitamin D metabolism
• It helps prevent and treat osteoporosis and other bone disorders
• It supports calcium homeostasis in patients with chronic conditions
• It addresses both calcium and vitamin D deficiencies simultaneously
• It's generally well-tolerated with proper dosing and monitoring
• It provides therapeutic benefits for patients on long-term corticosteroid therapy
• It helps maintain bone health in elderly patients and postmenopausal women

Substitutes of Bio-D3 Plus Capsule & Alternative Medicines

• Calcium carbonate + Vitamin D3 (cholecalciferol) tablets
• Calcium citrate + Vitamin D3 supplements
• Alphacalcidol capsules with separate calcium
• Calcium + Vitamin D + Vitamin K2 combinations
• Calcium with magnesium and zinc formulations
• Strontium ranelate (for severe osteoporosis)
• Bisphosphonates (for osteoporosis treatment)
• Parathyroid hormone analogs (for severe cases)
• Calcium-fortified foods and vitamin D-fortified dairy products
• Natural calcium sources combined with adequate sun exposure

Storage Guidelines

• Store at room temperature between 59°F to 86°F (15°C to 30°C)
• Keep away from direct sunlight, heat, and moisture
• Store in the original container with the lid tightly closed
• Keep out of reach of children
• Do not refrigerate or freeze the soft gelatin capsules
• Protect from extreme temperature variations
• Discard if the capsules become discolored or damaged
• Do not use after the expiration date printed on the package
• Avoid storing in bathroom medicine cabinets due to moisture
• Keep away from pets as ingestion may be harmful to animals

Quick Tips for Bio-D3 Plus Capsule

• Take consistently at the same time each day for best results
• Combine with weight-bearing exercise for optimal bone health
• Do not exceed recommended dosage unless directed by doctor
• Consider taking with meals containing some fat for better absorption
• Stay consistent with therapy as bone health benefits develop over time
• Keep regular follow-up appointments for monitoring
• Maintain adequate hydration while taking calcium supplements
• Report any unusual symptoms to your healthcare provider promptly
• Inform all healthcare providers that you are taking this supplement
• Continue the supplement as directed even if you feel well

Fact Box

• Chemical Class: Vitamin D analog (calcitriol) + Mineral supplement (calcium)
• Habit Forming: No
• Therapeutic Class: Calcium and vitamin D supplement
• Action Class: Bone metabolism regulator and calcium homeostasis agent

Useful Diagnostic Tests

• Serum calcium levels
• 25-hydroxyvitamin D levels
• Parathyroid hormone (PTH) levels
• Bone mineral density tests (DEXA scan)
• Kidney function tests (creatinine, BUN)
• Urinary calcium excretion
• Alkaline phosphatase levels
• Serum phosphorus levels
• Liver function tests
• Magnesium levels

More Information & References

For additional information about Bio-D3 Plus, consult:

• Your healthcare provider or pharmacist
• National Osteoporosis Foundation guidelines
• Institute of Medicine's recommendations for calcium and vitamin D intake
• Endocrine Society clinical practice guidelines
• Product information leaflet
• Reputable nutrition and bone health resources

Link to credible health sources:

• Drugs.com
• WHO
• NCBI

Disclaimer

This information is intended for educational purposes only and does not replace professional medical advice. Always consult with your healthcare provider before starting, stopping, or changing any medication or supplement regimen. Individual responses may vary, and potential risks and benefits should be discussed with your healthcare provider. This supplement should be used only as directed by a qualified healthcare professional.