Bisoheart 2.5 Tablet
Prescription Required
Marketer
Mankind Pharma Ltd
SALT COMPOSITION
Bisoprolol (2.5mg)
Storage
Store below 25°C
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Product Introduction
Bisoheart 2.5 Tablet is a prescription medication containing Bisoprolol Fumarate 2.5mg as its active ingredient. Bisoprolol belongs to a class of medications called beta-blockers, which work primarily by blocking the action of certain natural chemicals in the body such as adrenaline on the heart and blood vessels. This results in a reduction of heart rate, blood pressure, and strain on the heart, making it an essential medication for cardiovascular health management.
Bisoheart 2.5 Tablet is primarily prescribed for the treatment of hypertension (high blood pressure), angina pectoris (chest pain due to reduced blood flow to the heart), and chronic heart failure. Its cardioselective properties make it particularly useful for patients who need a beta-blocker with minimal effects on other organ systems.
The medication is known for its once-daily dosing regimen, which enhances patient compliance. The 2.5mg strength is often used as a starting dose, especially in heart failure patients, with the possibility of gradual upward titration based on individual response and tolerance.
Bisoheart 2.5 Tablet works by reducing the workload on the heart by slowing the heart rate and reducing the force of contraction. This helps improve the efficiency of the heart's pumping action and reduces oxygen demand. For patients with hypertension, it helps relax blood vessels, allowing blood to flow more easily and lowering blood pressure.
This medication has demonstrated significant benefits in improving survival rates and quality of life in patients with chronic heart failure when used as part of a comprehensive treatment regimen. For hypertensive patients, it offers effective blood pressure control with a favorable side effect profile compared to some other antihypertensive medications.
As with all prescription medications, Bisoheart 2.5 Tablet should only be taken under the supervision of a qualified healthcare provider. Regular monitoring is essential, particularly when initiating therapy or adjusting dosage, to ensure optimal therapeutic benefit while minimizing potential adverse effects.
Key Composition & Ingredients
- Bisoprolol Fumarate (2.5mg): A highly selective beta-1 adrenergic receptor blocker
- Inactive ingredients may include microcrystalline cellulose, calcium hydrogen phosphate, magnesium stearate, colloidal silicon dioxide, and various coating materials
Uses of Bisoheart Tablet
- Treatment of hypertension (high blood pressure)
- Management of chronic stable angina pectoris
- Treatment of stable chronic heart failure
- Prophylaxis of migraine headaches (off-label use)
- Reduction of cardiovascular mortality in patients with previous myocardial infarction
Benefits of Bisoheart Tablet
- Effective reduction in blood pressure with once-daily dosing
- Decreased frequency and severity of angina attacks
- Improved survival rates in chronic heart failure patients
- Reduced risk of cardiovascular events in high-risk patients
- Better exercise tolerance and improved quality of life
- Highly cardioselective, minimizing effects on other organ systems
- Well-tolerated compared to some other beta-blockers
- May help reduce symptoms of anxiety such as palpitations (off-label use)
How Bisoheart Tablet Works
How the Drug Works (Mechanism of Action)
Bisoprolol works by selectively blocking beta-1 adrenergic receptors, which are primarily found in the heart. This blockade results in:
- Decreased heart rate (negative chronotropic effect)
- Reduced force of heart contractions (negative inotropic effect)
- Decreased cardiac output and oxygen demand
- Reduced release of renin from the kidneys, contributing to blood pressure reduction
- Extended diastolic filling time, improving myocardial perfusion
- Suppression of renin-angiotensin-aldosterone system activation
The high cardioselectivity of bisoprolol means it primarily affects the heart while having minimal impact on beta-2 receptors found in the bronchi and blood vessels, which helps reduce unwanted side effects compared to non-selective beta-blockers.
Dosage of Bisoheart Tablet
Dosage (Daily Dose, Missed Dose, Overdose)
Standard Adult Dosage:
- Hypertension: Initially 2.5-5mg once daily, may be increased to 10-20mg once daily if needed
- Angina: 5-10mg once daily
- Heart Failure: Starting dose of 1.25mg once daily for first week, then 2.5mg once daily for one week, with gradual titration up to a maximum of 10mg once daily as tolerated
Missed Dose:
- Take as soon as remembered if within 12 hours of the scheduled time
- If closer to the next dose, skip the missed dose and resume regular schedule
- Do not double dose to make up for a missed dose
Overdose:
- Symptoms may include severe bradycardia, hypotension, bronchospasm, acute cardiac insufficiency, and hypoglycemia
- Seek immediate medical attention if overdose is suspected
- Treatment may include activated charcoal, gastric lavage, atropine for bradycardia, and intravenous fluids for hypotension
Mode of Action of Bisoheart Tablet
Bisoprolol selectively binds to beta-1 adrenergic receptors in cardiac tissue, preventing the binding of catecholamines (adrenaline and noradrenaline). This results in decreased sympathetic stimulation of the heart, leading to reduced heart rate, contractility, and conduction velocity within the heart. In hypertension, the reduced cardiac output and inhibition of renin release from the kidneys lead to decreased blood pressure. In heart failure, the reduced workload on the heart allows for improved cardiac efficiency over time.
How to Use Bisoheart Tablet
Directions for Use
- Take exactly as prescribed by your healthcare provider
- Take once daily, preferably in the morning
- Can be taken with or without food
- Swallow tablet whole with a glass of water; do not crush or chew
- Try to take at the same time each day to maintain consistent blood levels
- Continue taking even if you feel well; most cardiovascular conditions require ongoing treatment
- Do not stop taking abruptly without medical supervision
Side Effects of Bisoheart Tablet
Side Effects & How to Manage Them
Common Side Effects:
- Fatigue or tiredness (take at bedtime if problematic)
- Cold hands and feet (wear warm clothing, especially in cold weather)
- Slow heartbeat (usually not concerning if mild; report if severe)
- Dizziness (rise slowly from sitting or lying position)
- Sleep disturbances (take medication in the morning)
- Gastrointestinal disturbances (take with food)
Serious Side Effects (Seek medical attention immediately):
- Severe dizziness or fainting
- Shortness of breath or wheezing
- Swelling of ankles or feet
- Unusual weight gain
- Signs of heart block (very slow heartbeat)
- Severe depression or mood changes
- Signs of low blood sugar in diabetic patients
Safety Advice for Bisoheart Tablet
Alcohol: Limit alcohol consumption as it may enhance the blood pressure-lowering effect and increase dizziness.
Pregnancy: Generally not recommended during pregnancy unless clearly necessary. Category C - potential risks to the fetus.
Breastfeeding: Not recommended during breastfeeding. Bisoprolol passes into breast milk and may affect the infant.
Driving: May cause dizziness or fatigue. Avoid driving until you know how the medicine affects you.
Kidney: Use with caution in patients with kidney impairment. Dose adjustment may be required.
Liver: Use with caution in patients with liver disease. Lower doses may be necessary.
Children: Safety and efficacy not established in children.
Older Patients: May be more sensitive to side effects. Lower initial doses often recommended.
Lactation: Not recommended during breastfeeding.
Allergy: Contraindicated in patients with known hypersensitivity to bisoprolol or any other beta-blockers.
Warnings & Precautions of Bisoheart Tablet
- Do not stop taking abruptly; gradual dose reduction is necessary to avoid rebound effects
- Use with caution in patients with bronchial asthma or COPD
- May mask symptoms of hypoglycemia in diabetic patients
- Can worsen symptoms of peripheral vascular disease
- May exacerbate symptoms of myasthenia gravis
- Use with caution in patients with a history of severe allergic reactions
- May need dose adjustment before surgery
- Regular monitoring of heart rate and blood pressure recommended
- Special caution in patients with first-degree heart block
- May worsen symptoms of hyperthyroidism
Interactions with Bisoheart Tablet
Drug-Drug & Drug-Food Interactions
Drug Interactions:
- Calcium channel blockers (verapamil, diltiazem): Increased risk of bradycardia and heart block
- Other antihypertensives: Enhanced blood pressure-lowering effect
- Antiarrhythmics (amiodarone, flecainide): Increased risk of cardiac conduction abnormalities
- Clonidine: Potential for rebound hypertension if beta-blocker is withdrawn first
- Insulin and oral antidiabetics: May mask hypoglycemia symptoms
- NSAIDs: May reduce antihypertensive effect
- Anesthetic agents: Enhanced hypotensive effect
- Digoxin: Increased risk of bradycardia
- Rifampicin: May reduce bisoprolol levels
- MAO inhibitors: Potentiation of hypotensive effect
Food Interactions:
- No significant food interactions
- Grapefruit juice: No known interaction but best avoided with cardiovascular medications in general
Contraindications of Bisoheart Tablet
- Acute heart failure or cardiogenic shock
- Second or third-degree heart block (without a pacemaker)
- Sick sinus syndrome
- Severe bradycardia (heart rate less than 50 beats per minute)
- Severe hypotension (systolic blood pressure below 90 mmHg)
- Severe bronchial asthma or COPD
- Late stages of peripheral arterial occlusive disease
- Untreated pheochromocytoma
- Metabolic acidosis
- Known hypersensitivity to bisoprolol or any component of the formulation
Safety Measures & FDA Pregnancy Category
- FDA Pregnancy Category C: Risk cannot be ruled out
- Regular monitoring of blood pressure and heart rate
- Periodic assessment of blood glucose in diabetic patients
- Liver and kidney function tests recommended during long-term therapy
- ECG monitoring in patients with cardiac conditions
- Gradual dose titration when starting therapy
- Gradual withdrawal when discontinuing therapy
Diet & Lifestyle Advice
- Maintain a heart-healthy diet low in sodium and saturated fats
- Regular moderate exercise as approved by your healthcare provider
- Weight management for optimal blood pressure control
- Limit alcohol consumption
- Smoking cessation recommended
- Stress management techniques may be beneficial
- Monitor blood pressure regularly at home if possible
- Keep a log of blood pressure readings to share with your doctor
- Ensure adequate hydration while avoiding excessive fluid intake
Why Doctors Recommend This Medicine
Healthcare providers prescribe Bisoheart 2.5 Tablet because:
- It offers effective blood pressure control with once-daily dosing
- Its high cardioselectivity minimizes side effects on the respiratory system
- It improves survival in chronic heart failure patients
- It has a favorable side effect profile compared to other beta-blockers
- Its effectiveness is well-documented in numerous clinical trials
- It provides protection against cardiovascular events in high-risk patients
- It's available in multiple strengths for dose titration
Substitutes of Bisoheart Tablet & Alternative Medicines
Alternative beta-blockers include:
- Metoprolol (Toprol XL, Lopressor)
- Atenolol (Tenormin)
- Carvedilol (Coreg)
- Nebivolol (Bystolic)
Other classes of medications that may be alternatives depending on the condition:
- ACE inhibitors (enalapril, lisinopril)
- Angiotensin II receptor blockers (losartan, valsartan)
- Calcium channel blockers (amlodipine, diltiazem)
- Diuretics (hydrochlorothiazide, furosemide)
Storage Guidelines
- Store at room temperature between 15-30°C (59-86°F)
- Protect from light and moisture
- Keep away from direct sunlight
- Store in the original package or container
- Keep out of reach of children
- Do not use after the expiration date
- Do not store in the bathroom or near sinks
User Feedback & Patient Concerns
Common patient questions include:
- How long before I see improvement in my blood pressure?
- Can I stop taking it once my blood pressure is controlled?
- Will it affect my energy levels or exercise capacity?
- How should I monitor my heart rate while taking this medication?
- What should I do if I experience dizziness?
- Can I take over-the-counter medications with Bisoheart?
- How does it compare to other blood pressure medications I've taken?
Quick Tips for Bisoheart Tablet
- Take at the same time each day
- Do not stop taking suddenly; consult your doctor first
- Monitor your blood pressure and heart rate regularly
- Report unusual fatigue or dizziness to your doctor
- Carry medical identification stating you take a beta-blocker
- Keep follow-up appointments for proper monitoring
- Know how to check your pulse rate
- Rise slowly from sitting or lying to prevent dizziness
Fact Box
Chemical Class: Beta-adrenergic blocking agent (Beta-blocker)
Habit Forming: No
Therapeutic Class: Antihypertensive, Antianginal, Heart failure treatment
Action Class: Cardioselective beta-1 receptor antagonist
Useful Diagnostic Tests
Before or during treatment, the following tests may be recommended:
- Blood pressure monitoring
- Heart rate measurement
- ECG (electrocardiogram)
- Kidney function tests
- Liver function tests
- Blood glucose levels for diabetic patients
- Lipid profile
- Pulmonary function tests in patients with respiratory conditions
More Information & References
For more information, consult reputable medical resources such as:
- American Heart Association guidelines
- European Society of Cardiology guidelines
- Journal of Hypertension
- Heart Failure Society of America recommendations
- British National Formulary
Disclaimer
This information is for educational purposes only and not a substitute for professional medical advice. Always consult your healthcare provider before starting or changing any medication regimen. Individual responses to medication may vary. Patients should not adjust dosages without medical supervision.
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