Brakke Tablet
Prescription Required
Marketer
Franco-Indian Pharmaceuticals Pvt Ltd
SALT COMPOSITION
Ofloxacin (200mg) + Ornidazole (500mg)
Storage
Store below 30°C
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Product Introduction
Brakke Tablet is a powerful dual-action antibiotic and antiprotozoal medication combining Ofloxacin (200mg) and Ornidazole (500mg) in a single tablet formulation. This fixed-dose combination is designed to provide comprehensive antimicrobial coverage against a wide spectrum of bacterial and protozoal infections.
Ofloxacin belongs to the fluoroquinolone class of antibiotics, which are effective against many gram-positive and gram-negative bacteria. It works by inhibiting bacterial DNA gyrase, an enzyme essential for bacterial DNA replication, thereby preventing bacteria from reproducing and spreading infection.
Ornidazole is a nitroimidazole antiprotozoal agent that targets anaerobic bacteria and certain protozoal parasites. It becomes activated inside microbial cells, damaging their DNA and ultimately causing cell death.
This combination is particularly valuable for treating mixed infections where both aerobic bacteria and anaerobic microorganisms may be present. Common indications include gastrointestinal infections, pelvic inflammatory disease, respiratory tract infections, urinary tract infections, skin and soft tissue infections, and certain sexually transmitted infections.
Brakke Tablet is prescribed by healthcare professionals when a broader spectrum of antimicrobial activity is required than what can be achieved with a single agent. The synergistic action of these two compounds provides enhanced therapeutic efficacy, broader coverage, and potentially reduces the risk of antimicrobial resistance.
This medication is available by prescription only and should be taken exactly as directed by your healthcare provider. The dosage and duration of treatment will depend on the type and severity of the infection being treated, as well as individual patient factors.
As with all antimicrobial medications, Brakke Tablet should be used responsibly to ensure optimal effectiveness and to minimize the development of resistance. It's important to complete the full course of treatment even if symptoms improve before the medication is finished.
For patients with certain pre-existing conditions such as kidney or liver impairment, epilepsy, or G6PD deficiency, special dosing considerations may be necessary. Always inform your healthcare provider about your complete medical history and any other medications you may be taking before starting treatment with Brakke Tablet.
Key Composition & Ingredients
- Ofloxacin (200mg): A broad-spectrum fluoroquinolone antibiotic effective against many gram-positive and gram-negative bacteria
- Ornidazole (500mg): A nitroimidazole antiprotozoal agent effective against anaerobic bacteria and certain protozoal parasites
Uses of Brakke Tablet
- Treatment of gastrointestinal infections (bacterial dysentery, amoebiasis)
- Pelvic inflammatory disease
- Respiratory tract infections
- Urinary tract infections
- Skin and soft tissue infections
- Gynecological infections
- Mixed aerobic and anaerobic infections
- Prophylaxis in abdominal surgeries
Benefits of Brakke Tablet
- Provides broad-spectrum coverage against bacteria and protozoa
- Treats mixed infections with a single formulation
- Reduces bacterial resistance potential through dual mechanism action
- Convenient once or twice daily dosing
- Rapid relief from infection symptoms
- Higher cure rates for complex infections
- Reduces the need for multiple medications
How Brakke Tablet Works
Brakke Tablet works through the complementary actions of its two active ingredients:
How the Drug Works (Mechanism of Action)
Ofloxacin (200mg):
- Inhibits bacterial DNA gyrase and topoisomerase IV
- Prevents bacterial DNA replication and transcription
- Causes rapid bacterial cell death
- Effective primarily against aerobic bacteria
Ornidazole (500mg):
- Enters microbial cells by passive diffusion
- Undergoes reduction by microbial enzymes to form toxic metabolites
- Damages microbial DNA through oxidative processes
- Effective against anaerobic bacteria and protozoa
Dosage of Brakke Tablet
Dosage (Daily Dose, Missed Dose, Overdose)
Standard Adult Dosage:
- Typically one tablet twice daily for 5-10 days, depending on the infection
- Take with or after meals to minimize gastrointestinal discomfort
Missed Dose:
- Take as soon as remembered if within a few hours
- Skip the missed dose if it's almost time for the next scheduled dose
- Never take a double dose to compensate for a missed one
Overdose:
- Symptoms may include nausea, vomiting, dizziness, confusion, seizures
- Seek immediate medical attention if overdose is suspected
- Treatment is supportive and symptomatic
Mode of Action of Brakke Tablet
The dual components of Brakke Tablet work synergistically:
- Ofloxacin targets DNA gyrase to disrupt bacterial replication
- Ornidazole forms toxic metabolites that damage microbial DNA
- Together they provide comprehensive coverage against mixed infections
How to Use Brakke Tablet
Directions for Use
- Take as prescribed by your healthcare provider
- Swallow tablet whole with a full glass of water
- Can be taken with or after food to reduce stomach upset
- Maintain even spacing between doses for optimal blood levels
- Complete the full course of treatment even if symptoms improve
- Avoid dairy products, antacids, or multivitamins with minerals within 2 hours of taking the tablet
Side Effects of Brakke Tablet
Side Effects & How to Manage Them
Common Side Effects:
- Nausea/vomiting (take with food)
- Headache (take appropriate pain reliever if necessary)
- Dizziness (avoid driving or operating machinery)
- Metallic taste (temporary, can suck on sugar-free candy)
- Diarrhea (stay hydrated, consider probiotics)
Serious Side Effects (Seek medical attention immediately):
- Severe allergic reactions (rash, itching, swelling)
- Tendon pain or inflammation
- Severe diarrhea or stomach pain
- Neurological symptoms (seizures, peripheral neuropathy)
- Photosensitivity reactions
- QT interval prolongation (irregular heartbeat)
Safety Advice for Brakke Tablet
Alcohol: Avoid alcohol during treatment and for 48 hours after the last dose as it may cause disulfiram-like reaction with ornidazole
Pregnancy: Generally not recommended unless clearly necessary. Consult your doctor.
Breastfeeding: Not recommended during treatment. Alternative feeding methods should be considered.
Driving: May cause dizziness and visual disturbances. Avoid driving until you know how the medicine affects you.
Kidney: Use with caution in patients with kidney impairment. Dose adjustment may be required.
Liver: Use with caution in patients with liver disease. Dose adjustment may be necessary.
Children: Not recommended for children and adolescents under 18 years.
Older Patients: Lower doses may be recommended. Increased risk of tendon disorders.
Lactation: Not recommended during breastfeeding.
Allergy: Contraindicated in patients with known hypersensitivity to fluoroquinolones or nitroimidazoles.
Warnings & Precautions of Brakke Tablet
- May cause tendon inflammation or rupture, particularly in older patients
- Risk of peripheral neuropathy
- May exacerbate myasthenia gravis
- May cause central nervous system effects (dizziness, confusion)
- Photosensitivity reactions may occur (avoid sun exposure)
- May affect blood glucose levels in diabetic patients
- Risk of C. difficile-associated diarrhea
- May prolong QT interval in susceptible individuals
- Potential for disulfiram-like reaction with alcohol
Interactions with Brakke Tablet
Drug-Drug & Drug-Food Interactions
Drug Interactions:
- Antacids, iron, zinc, calcium supplements (reduce absorption)
- NSAIDs (increased risk of seizures)
- Warfarin (enhanced anticoagulant effect)
- Corticosteroids (increased risk of tendon problems)
- Antidiabetic medications (may affect blood glucose)
- Theophylline (increased theophylline levels)
- QT-prolonging medications (increased risk of arrhythmias)
Food Interactions:
- Dairy products may reduce absorption (take 2 hours apart)
- Caffeine levels may be increased
- Food does not significantly affect overall absorption
Contraindications of Brakke Tablet
- Hypersensitivity to fluoroquinolones or nitroimidazoles
- History of tendon disorders related to fluoroquinolone use
- Epilepsy or seizure disorders
- G6PD deficiency
- Myasthenia gravis
- Pregnancy and breastfeeding
- Children and adolescents under 18 years
- Patients with known QT interval prolongation
- History of psychiatric disorders
Safety Measures & FDA Pregnancy Category
- FDA Pregnancy Category C: Risk cannot be ruled out
- Black Box Warning for tendinitis, tendon rupture, and peripheral neuropathy
- Special precautions for patients with CNS disorders
- Monitoring of liver and kidney function may be recommended
- Regular clinical assessment during prolonged therapy
Diet & Lifestyle Advice
- Maintain adequate hydration during treatment
- Avoid alcohol during and for 48 hours after treatment
- Protect skin from sun exposure
- Complete the full course of medication
- Report any unusual symptoms to your healthcare provider
- Probiotics may help reduce gastrointestinal side effects
- Avoid strenuous exercise during treatment (tendon risk)
Why Doctors Recommend This Medicine
Healthcare providers prescribe Brakke Tablet for its:
- Broad-spectrum coverage for mixed infections
- Convenient dosing schedule
- High efficacy rates for indicated infections
- Synergistic action of two complementary antimicrobials
- Good tissue penetration for deep-seated infections
Substitutes of Brakke Tablet & Alternative Medicines
Alternative combinations with similar ingredients include:
- Oflox-OZ Tablet
- Orni-O Tablet
- Oflotas-OZ Tablet
- Ciprobid-O Tablet (Ciprofloxacin + Ornidazole)
- Individual components may be prescribed separately
Storage Guidelines
- Store at room temperature (15-30°C)
- Keep away from direct sunlight and moisture
- Keep out of reach of children
- Do not use after the expiration date
- Keep in the original packaging until ready to use
User Feedback & Patient Concerns
Common patient questions include:
- Duration of treatment needed
- Compatibility with other medications
- Management of side effects
- When to expect improvement in symptoms
- Dietary restrictions during treatment
Quick Tips for Brakke Tablet
- Take at the same times each day
- Complete the full course even if feeling better
- Stay well-hydrated during treatment
- Avoid direct sunlight
- Inform your doctor of any unusual symptoms
- Take with food if stomach upset occurs
- Avoid alcohol during and for 48 hours after treatment
Fact Box
Chemical Class:
- Ofloxacin: Fluoroquinolone
- Ornidazole: Nitroimidazole
Habit Forming: No
Therapeutic Class: Antimicrobial combination
Action Class: Antibiotic and antiprotozoal
Useful Diagnostic Tests
Before or during treatment, the following tests may be recommended:
- Culture and sensitivity testing
- Liver function tests
- Kidney function tests
- Complete blood count
- ECG in high-risk patients
More Information & References
For more information, consult reputable medical resources such as:
- National Center for Biotechnology Information
- World Health Organization guidelines
- Clinical Infectious Diseases journal
- British National Formulary
Disclaimer
This information is for educational purposes only and not a substitute for professional medical advice. Always consult your healthcare provider before starting or changing any medication regimen. Individual responses to medication may vary.
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Brakke Tablet – Anti-Infective Medicine for Bacterial & Parasitic Infections | Buy at RXDawa