Brevipil 50 Tablet
Prescription Required
Marketer
Sun Pharmaceutical Industries Ltd
SALT COMPOSITION
Brivaracetam (50mg)
Storage
Store below 30°C
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Product Introduction
Brevipil 50 Tablet contains Brivaracetam 50mg as its active ingredient, an advanced anticonvulsant medication primarily prescribed for the management of epilepsy. Developed as a high-affinity synaptic vesicle protein 2A (SV2A) ligand, Brivaracetam represents a newer generation of antiepileptic drugs designed to provide effective seizure control with a favorable safety profile.
Epilepsy affects approximately 50 million people worldwide and is characterized by recurrent, unprovoked seizures that can significantly impact quality of life. Brevipil 50 is specifically indicated as adjunctive therapy in the treatment of partial-onset seizures in patients 16 years of age and older with epilepsy. Its unique mechanism of action targets the SV2A protein, which plays a crucial role in neurotransmitter release and synaptic function in the brain.
What distinguishes Brivaracetam from its predecessor levetiracetam is its higher binding affinity to SV2A and potentially faster onset of action. This enhanced potency may translate to improved seizure control for patients who have not responded adequately to other antiepileptic medications. Additionally, Brevipil 50 has demonstrated effectiveness across various seizure types, including complex partial seizures and secondarily generalized seizures.
The 50mg strength represents a standard therapeutic dose for many patients, though dosing may be individualized based on clinical response and tolerability. Brevipil 50 is designed for oral administration and features a pharmacokinetic profile that allows for twice-daily dosing, promoting medication adherence. It is rapidly and completely absorbed after oral administration, with minimal protein binding and limited metabolism, reducing the risk of drug-drug interactions.
As with all antiepileptic medications, Brevipil 50 should be used under close medical supervision, with particular attention to proper titration, monitoring for side effects, and evaluating ongoing seizure control. This medication offers new hope for patients with difficult-to-control epilepsy who may benefit from its novel mechanism of action and targeted anticonvulsant properties.
Key Composition & Ingredients
- Active Ingredient: Brivaracetam (50mg)
- Inactive Ingredients: May include microcrystalline cellulose, croscarmellose sodium, lactose monohydrate, magnesium stearate, and pharmaceutical-grade coating materials
Uses of Brevipil 50 Tablet
- Adjunctive therapy in the treatment of partial-onset seizures in patients 16 years and older with epilepsy
- Management of primary generalized tonic-clonic seizures
- Control of focal seizures with or without secondary generalization
- Alternative therapy for patients who have not responded adequately to other antiepileptic drugs
Benefits of Brevipil 50 Tablet
- Provides effective seizure control with a rapid onset of action
- Features a favorable pharmacokinetic profile with minimal drug interactions
- May be effective in patients who have shown resistance to other antiepileptic medications
- Offers twice-daily dosing to promote medication adherence
- Shows minimal impact on liver enzyme induction
- Demonstrates good tolerability in many patients
- Can be taken with or without food for convenience
How Brevipil 50 Tablet Works
Brivaracetam works through a specialized mechanism targeting neuronal excitability:
- Selectively binds to synaptic vesicle protein 2A (SV2A) with high affinity
- Modulates neurotransmitter release in the brain by affecting synaptic vesicle functioning
- Reduces neuronal hyperexcitability that contributes to seizure generation
- May inhibit voltage-dependent sodium channels, further contributing to its anticonvulsant effects
- Stabilizes neuronal membranes to prevent excessive electrical activity
Dosage of Brevipil 50 Tablet
Daily Dose
- Initial dose: 50mg twice daily (100mg/day)
- Maintenance dose: 25-100mg twice daily (50-200mg/day)
- Maximum recommended dose: 100mg twice daily (200mg/day)
- Dosing frequency: Administered in two equally divided doses, approximately 12 hours apart
Missed Dose
- Take the missed dose as soon as remembered if it's within a few hours
- If close to the next scheduled dose, skip the missed dose and resume regular schedule
- Do not double dose to make up for a missed dose
Overdose
- Symptoms may include drowsiness, dizziness, fatigue, balance disorder, and potential cardiac effects
- Seek immediate medical attention if overdose is suspected
- Supportive care is the primary treatment for overdose
How to Use Brevipil 50 Tablet
- Take by mouth with a glass of water
- Can be taken with or without food
- Swallow tablets whole; do not crush, chew, or break
- Take at the same times each day to maintain consistent blood levels
- Follow doctor's instructions precisely regarding dosage and timing
Side Effects of Brevipil 50 Tablet
Common Side Effects
- Somnolence (sleepiness)
- Dizziness
- Fatigue
- Nausea
- Headache
- Balance disorder
- Irritability
Serious Side Effects
- Psychiatric symptoms (mood changes, suicidal thoughts)
- Hypersensitivity reactions (rash, swelling)
- Coordination difficulties and ataxia
- Severe neurological reactions
- Vision changes or abnormalities
- Rare cases of liver dysfunction
Safety Advice for Brevipil 50 Tablet
Alcohol
- Avoid alcohol consumption as it may increase drowsiness and dizziness
Pregnancy
- Pregnancy Category C: Use only if benefits outweigh potential risks
- Consult healthcare provider regarding pregnancy registry and management
Breastfeeding
- May pass into breast milk; discuss risks and benefits with healthcare provider
Driving
- May cause drowsiness and affect coordination; avoid driving until response to medication is known
Kidney Function
- Dose adjustment recommended for patients with severe renal impairment
- Regular monitoring of kidney function may be necessary
Liver Function
- Use with caution in patients with liver impairment
- Dosage adjustment may be required for severe hepatic impairment
Children
- Safety and efficacy not fully established in children under 16 years
Older Patients
- May require lower doses due to age-related changes in kidney function
- Monitor more closely for side effects
Allergy
- Discontinue immediately if signs of allergic reaction occur
Warnings & Precautions
- Risk of suicidal thoughts or behavior; monitor for mood changes
- Do not discontinue abruptly as this may increase seizure frequency
- Use caution when operating machinery or performing tasks requiring alertness
- Monitor for neuropsychiatric symptoms (aggression, psychosis, mood disorders)
- Requires periodic blood tests to monitor overall health
- May interact with other medications; inform all healthcare providers about current medications
- Exercise caution in patients with history of psychiatric disorders
Interactions with Brevipil 50 Tablet
Drug-Drug Interactions
- May interact with other antiepileptic drugs, potentially requiring dose adjustments
- Limited effect on liver enzymes, resulting in fewer interactions than many other antiepileptics
- May have interactions with strong CYP2C19 inhibitors
- Potential interactions with rifampin and carbamazepine
- Minimal interaction with oral contraceptives
Drug-Food Interactions
- No significant known food interactions
- Can be taken with or without food
Contraindications
- Hypersensitivity to Brivaracetam or any component of the formulation
- Previous severe allergic reaction to levetiracetam
- Severe liver disease (use with caution and dose adjustment)
Diet & Lifestyle Advice
- Maintain regular sleep patterns to help reduce seizure triggers
- Avoid excessive caffeine consumption
- Manage stress through appropriate techniques
- Stay well-hydrated throughout the day
- Wear medical identification indicating epilepsy diagnosis
- Keep a seizure diary to track patterns and medication effectiveness
- Avoid activities that could be dangerous during a seizure until control is established
Why Doctors Recommend This Medicine
Physicians prescribe Brevipil 50 because:
- It offers a novel mechanism of action for seizure control
- Shows efficacy in patients with refractory epilepsy
- Has fewer drug-drug interactions than many other antiepileptics
- Provides rapid onset of action for seizure control
- Can be used as adjunctive therapy with other antiepileptic medications
- Has a favorable side effect profile for many patients
Substitutes & Alternative Medicines
Pharmaceutical Alternatives
- Levetiracetam
- Lamotrigine
- Topiramate
- Lacosamide
- Perampanel
Note on Alternatives
Always consult with a healthcare provider before switching antiepileptic medications. Abrupt changes can trigger seizures or other adverse effects.
Storage Guidelines
- Store at room temperature between 68-77°F (20-25°C)
- Keep away from moisture and direct sunlight
- Store in the original package to protect from environmental conditions
- Keep out of reach of children
- Do not use after the expiration date printed on the package
User Feedback & Patient Concerns
Common patient feedback includes:
- Reports of improved seizure control compared to previous medications
- Questions about long-term side effects
- Concerns about drowsiness affecting daily activities
- Feedback about cognitive effects during initial treatment period
- Interest in potential drug interactions with current medications
Quick Tips
- Take medication consistently at the same times each day
- Keep a seizure diary to track effectiveness
- Do not abruptly discontinue without medical supervision
- Allow time to adjust to potential side effects, many diminish over time
- Inform all healthcare providers about all medications being taken
- Carry medical identification indicating epilepsy diagnosis and medications
- Report any unusual mood changes or thoughts to healthcare provider immediately
Fact Box
- Chemical Class: Racetam derivative
- Habit Forming: No
- Therapeutic Class: Anticonvulsant/Antiepileptic
- Action Class: Synaptic vesicle protein 2A (SV2A) ligand
Useful Diagnostic Tests
- Baseline and periodic liver function tests
- Complete blood count
- Kidney function tests
- Electroencephalogram (EEG) to monitor seizure activity
- Drug level monitoring in certain clinical situations
Disclaimer
This information is provided for educational purposes only and should not replace professional medical advice. Consult your healthcare provider before starting, stopping, or changing any medication regimen. Individual responses to medications may vary.
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