Brutaflam-MR 4 Tablet – Muscle Spasm Pain Relief

Brutaflam-MR 4 Tablet

Prescription Required

Marketer

Mankind Pharma Ltd

SALT COMPOSITION

Etoricoxib (60mg) + Thiocolchicoside (4mg)

Storage

Store below 30°C

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Product Introduction

Brutaflam-MR 4 Tablet is a fixed-dose combination medication containing two active ingredients: Etoricoxib (60mg) and Thiocolchicoside (4mg). This dual-action formulation is specifically designed to address both pain and muscle spasms, making it a valuable therapeutic option for musculoskeletal conditions.

Etoricoxib belongs to the class of selective COX-2 inhibitors, a type of non-steroidal anti-inflammatory drug (NSAID) that provides effective pain relief and reduces inflammation with potentially fewer gastrointestinal side effects than traditional NSAIDs. Thiocolchicoside is a muscle relaxant that works centrally to relieve muscle spasms and associated discomfort.

This combination medication is particularly beneficial for conditions where both inflammation and muscle spasticity contribute to the patient's symptoms. The synergistic action of these two components offers more comprehensive relief than either medication alone would provide.

Brutaflam-MR 4 Tablet is commonly prescribed for acute painful musculoskeletal conditions such as low back pain, neck pain, and various forms of arthritis accompanied by muscle spasms. The medication works to reduce inflammation, alleviate pain, and relax tense muscles, thereby improving mobility and function.

The tablet is designed for short-term use, typically for periods ranging from 3-7 days or as directed by a healthcare professional. While effective for acute pain management, this medication requires appropriate medical supervision due to potential side effects and contraindications.

As with any prescription medication, Brutaflam-MR 4 should be taken exactly as prescribed, and patients should be aware of both the benefits and risks associated with its use. The medication represents an important therapeutic option for managing acute musculoskeletal pain when conservative measures alone prove insufficient.

Key Composition & Ingredients

The primary active ingredients in Brutaflam-MR 4 Tablet are:

• Etoricoxib 60mg: A selective COX-2 inhibitor that provides anti-inflammatory and analgesic effects
• Thiocolchicoside 4mg: A muscle relaxant that reduces muscle spasticity

Inactive ingredients may include:

• Microcrystalline cellulose
• Lactose monohydrate
• Croscarmellose sodium
• Magnesium stearate
• Titanium dioxide
• Hydroxypropyl methylcellulose
• Pharmaceutical grade excipients

Uses of Brutaflam-MR 4 Tablet

Brutaflam-MR 4 Tablet is prescribed for:

• Acute low back pain
• Cervical spondylosis with muscle spasm
• Musculoskeletal pain with associated muscle stiffness
• Postoperative pain management after orthopedic procedures
• Traumatic injuries with inflammation and muscle spasm
• Osteoarthritis flare-ups with muscle tension
• Acute painful shoulder conditions (adhesive capsulitis, rotator cuff tendinitis)
• Fibromyalgia (in some cases)
• Sports injuries involving both inflammation and muscle spasms
• Radicular pain with associated muscle spasticity

Benefits of Brutaflam-MR 4 Tablet

• Dual-action formula targets both inflammation and muscle spasms simultaneously
• Provides effective pain relief through COX-2 inhibition
• Reduces muscle stiffness and improves mobility
• Potentially fewer gastrointestinal side effects than traditional NSAIDs
• Improves quality of life by addressing multiple symptoms
• Enhances physical function and range of motion
• Helps break the pain-spasm-pain cycle
• May reduce the need for multiple medications
• Facilitates physical therapy and rehabilitation
• Provides relief from acute musculoskeletal conditions

How Brutaflam-MR 4 Tablet Works (Mechanism of Action)

Etoricoxib (60mg): Etoricoxib selectively inhibits cyclooxygenase-2 (COX-2), an enzyme responsible for producing prostaglandins that cause pain and inflammation. By targeting COX-2 while largely sparing COX-1 (which helps maintain the protective lining of the stomach), etoricoxib reduces inflammation and pain with potentially less risk of gastrointestinal ulceration compared to non-selective NSAIDs.

Thiocolchicoside (4mg): Thiocolchicoside acts as a competitive GABA-A receptor antagonist and glycine receptor antagonist in the central nervous system. It reduces muscle tone by inhibiting polysynaptic reflexes at the spinal level and has additional anti-inflammatory properties. Thiocolchicoside relaxes skeletal muscles by affecting the nervous impulse transmission to muscle fibers, relieving painful muscle contractions and spasticity.

The combination works synergistically - while etoricoxib addresses pain and inflammation, thiocolchicoside relieves the associated muscle spasms, providing comprehensive relief from musculoskeletal discomfort.

Dosage of Brutaflam-MR 4 Tablet

Standard Adult Dose:

• One tablet twice daily, typically for 3-7 days or as directed by the physician
• Maximum duration usually recommended is 7 days for thiocolchicoside component

Missed Dose:

• If a dose is missed, take it as soon as remembered
• If it's almost time for the next dose, skip the missed dose
• Do not double the dose to compensate for a missed dose

Overdose:

• Symptoms may include increased gastrointestinal effects, dizziness, nausea, vomiting, gastric pain, or neurological symptoms
• Seek immediate medical attention if overdose is suspected
• No specific antidote; treatment is symptomatic and supportive

How to Use Brutaflam-MR 4 Tablet

• Take tablet with sufficient water (at least 8 ounces)
• Best taken after meals to minimize stomach irritation
• Swallow tablet whole; do not crush, chew, or break
• Take at approximately the same times each day to maintain blood levels
• Do not exceed the prescribed dose or duration
• Complete the course as prescribed, even if symptoms improve
• If stomach upset occurs, may be taken with food or milk
• Store at room temperature away from moisture and light

Side Effects of Brutaflam-MR 4 Tablet

Common Side Effects:

• Nausea
• Dyspepsia (indigestion)
• Dizziness
• Headache
• Drowsiness
• Mild gastric discomfort
• Diarrhea or constipation
• Fatigue

Uncommon Side Effects:

• Elevated blood pressure
• Edema (fluid retention)
• Palpitations
• Insomnia
• Muscle weakness
• Blurred vision
• Vertigo
• Rash or itching

Rare but Serious Side Effects (requiring immediate medical attention):

• Chest pain or shortness of breath
• Black/tarry stools or vomiting of blood (gastrointestinal bleeding)
• Severe skin reactions
• Signs of liver problems (yellowing of skin/eyes, dark urine)
• Signs of kidney problems (decreased urination)
• Allergic reactions including swelling of face/throat
• Seizures or hallucinations
• Unusual bruising or bleeding

Management of Side Effects:

• Take with food to reduce gastrointestinal effects
• Stay well-hydrated
• Monitor blood pressure regularly if prescribed for longer periods
• Avoid driving or operating machinery if experiencing drowsiness
• Report any concerning symptoms to healthcare provider immediately

Safety Advice for Brutaflam-MR 4 Tablet

Alcohol: Avoid alcohol consumption while taking this medication as it may increase the risk of stomach bleeding and liver problems.

Pregnancy: Category D. Not recommended during pregnancy, especially in the third trimester. Etoricoxib may cause premature closure of the ductus arteriosus in the developing fetus. Thiocolchicoside is contraindicated in pregnancy due to potential teratogenic effects.

Breastfeeding: Not recommended during breastfeeding as both active ingredients may pass into breast milk.

Driving: May cause drowsiness or dizziness. Avoid driving or operating machinery until you know how this medication affects you.

Kidney: Use with caution in patients with mild to moderate kidney disease. Not recommended in severe renal impairment.

Liver: Use with caution in mild liver disease. Contraindicated in moderate to severe liver impairment.

Children: Not recommended for children and adolescents under 18 years of age.

Older Patients: Use with caution in elderly patients; they may be more susceptible to side effects. Lower doses may be appropriate.

Allergy: Contraindicated in patients with known hypersensitivity to etoricoxib, thiocolchicoside, sulfonamides, or any components of the formulation.

Warnings & Precautions for Brutaflam-MR 4 Tablet

• Not recommended for patients with established cardiovascular disease, uncontrolled hypertension, or significant risk factors for cardiovascular events
• Contraindicated in patients with active peptic ulcer disease or gastrointestinal bleeding
• Risk of serious cardiovascular thrombotic events, including myocardial infarction and stroke
• May cause or worsen hypertension; monitor blood pressure regularly
• Use with caution in patients with history of epilepsy due to potential for thiocolchicoside to lower seizure threshold
• Avoid use in patients with inflammatory bowel disease
• Not suitable for long-term use due to potential toxicity
• Discontinue immediately if signs of liver or kidney dysfunction develop
• Not recommended for use before or after coronary artery bypass graft (CABG) surgery
• May mask signs of infection or inflammation
• Genetic polymorphism of CYP2C9 may increase risk of adverse reactions
• Thiocolchicoside should not be used for more than 7 consecutive days

Interactions with Brutaflam-MR 4 Tablet

Drug Interactions:

• Anticoagulants (warfarin, heparin): Increased risk of bleeding
• Other NSAIDs or corticosteroids: Enhanced risk of gastrointestinal side effects
• ACE inhibitors/ARBs: Reduced antihypertensive efficacy and increased risk of kidney damage
• Diuretics: Reduced diuretic effect and increased nephrotoxicity risk
• Methotrexate: Increased methotrexate levels and toxicity
• Lithium: Increased lithium plasma levels and toxicity
• Cyclosporine: Increased nephrotoxicity
• SSRIs/SNRIs: Increased risk of gastrointestinal bleeding
• Oral hypoglycemics: May enhance hypoglycemic effect
• Antiepileptic drugs: Thiocolchicoside may lower seizure threshold
• CNS depressants: Additive sedative effects with thiocolchicoside

Food Interactions:

• High-fat meals may delay absorption of etoricoxib
• Take with food to minimize gastrointestinal side effects
• Avoid grapefruit juice as it may interfere with drug metabolism

Contraindications of Brutaflam-MR 4 Tablet

Brutaflam-MR 4 Tablet is contraindicated in:

• Hypersensitivity to etoricoxib, thiocolchicoside, or any component of the formulation
• Patients with history of aspirin-induced asthma, urticaria, or allergic reactions to NSAIDs
• Active peptic ulcer disease or gastrointestinal bleeding
• Severe renal impairment (creatinine clearance <30 mL/min)
• Severe hepatic impairment
• Inflammatory bowel disease
• Ischemic heart disease, cerebrovascular disease, peripheral arterial disease
• Congestive heart failure (NYHA II-IV)
• Pregnancy and breastfeeding
• Patients with epilepsy or history of seizures
• Children and adolescents under 18 years
• Before or after coronary artery bypass graft (CABG) surgery
• Muscular hypertonia disorders with spasticity of central origin

Diet & Lifestyle Advice

• Maintain proper hydration while taking this medication
• Follow a balanced diet rich in fruits, vegetables, and whole grains
• Consider an anti-inflammatory diet that includes omega-3 fatty acids
• Apply hot or cold packs to affected areas as recommended by your healthcare provider
• Practice gentle stretching exercises as appropriate for your condition
• Maintain proper posture during daily activities
• Use ergonomic tools and furniture to reduce strain on muscles and joints
• Consider complementary therapies like physical therapy or gentle massage
• Ensure adequate rest periods and avoid overexertion
• Maintain a healthy weight to reduce stress on joints and muscles
• Practice stress-reduction techniques such as meditation or deep breathing

Why Doctors Recommend This Medicine

Physicians prescribe Brutaflam-MR 4 Tablet when:

• Both pain/inflammation and muscle spasm need to be addressed simultaneously
• Other single-agent therapies have failed to provide adequate relief
• Patient requires rapid relief from acute musculoskeletal conditions
• Conservative measures like rest and physical therapy need pharmacological support
• The synergistic effect of dual mechanism is needed for comprehensive symptom management
• Short-term intensive therapy is required to break the pain-spasm cycle
• Patient mobility and function need to be restored quickly to prevent further complications
• The risk-benefit ratio favors short-term use of this combination

Substitutes of Brutaflam-MR 4 Tablet & Alternative Medicines

Similar combination products:

• Etodol-MR (Etoricoxib + Thiocolchicoside)
• Nucoxia-MR (Etoricoxib + Thiocolchicoside)
• Etova-TH (Etoricoxib + Thiocolchicoside)
• Torlactone-E (Etoricoxib + Thiocolchicoside)

Alternative medications:

• Aceclofenac + Thiocolchicoside combinations
• Diclofenac + Thiocolchicoside combinations
• Lornoxicam + Thiocolchicoside combinations
• Celecoxib + Muscle relaxants
• Naproxen + Muscle relaxants

Non-pharmacological alternatives:

• Physical therapy and rehabilitation
• Hot/cold therapy
• Transcutaneous electrical nerve stimulation (TENS)
• Acupuncture
• Massage therapy
• Strengthening exercises
• Yoga or gentle stretching

Storage Guidelines

• Store at room temperature between 15-30°C (59-86°F)
• Keep away from direct light, heat, and moisture
• Keep out of reach of children
• Do not store in the bathroom
• Keep in the original container or packaging
• Check expiration date before use
• Do not use medication past the expiry date
• Dispose of unused or expired medication properly

User Feedback & Patient Concerns

Common positive feedback:

• Rapid relief from both pain and muscle spasms
• Improved mobility and function
• Better sleep due to pain reduction
• Fewer pills needed compared to taking separate medications
• Reduced impact of acute pain episodes

Common concerns:

• Gastrointestinal discomfort reported by some users
• Drowsiness affecting daily activities
• Concerns about cardiovascular risks with prolonged use
• Questions about duration of treatment
• Interactions with other medications

Quick Tips for Brutaflam-MR 4 Tablet

• Take after meals to reduce stomach irritation
• Complete the prescribed course even if symptoms improve
• Do not extend use beyond recommended duration (typically 7 days)
• Avoid driving initially until you know how the medication affects you
• Keep track of blood pressure while on this medication
• Report any unusual side effects to your doctor immediately
• Do not take additional pain relievers without consulting your doctor
• Stay well-hydrated during treatment
• Avoid alcohol consumption
• Follow up with your healthcare provider as recommended

Fact Box

Chemical Class:

• Etoricoxib: Selective COX-2 inhibitor
• Thiocolchicoside: Semi-synthetic derivative of colchicoside

Habit Forming: No, but not recommended for extended use

Therapeutic Class:

• Etoricoxib: NSAID (Non-steroidal anti-inflammatory drug)
• Thiocolchicoside: Muscle relaxant

Action Class:

• Etoricoxib: Anti-inflammatory and analgesic
• Thiocolchicoside: Centrally acting muscle relaxant

Useful Diagnostic Tests

• Liver function tests before and during therapy if used beyond recommended duration
• Kidney function tests in at-risk patients
• Blood pressure monitoring
• Complete blood count if long-term use is considered
• Cardiac evaluation for patients with cardiovascular risk factors
• Imaging studies (X-ray, MRI) to diagnose underlying musculoskeletal conditions

More Information & References

Brutaflam-MR 4 Tablet contains a balanced combination of an anti-inflammatory agent and muscle relaxant designed for short-term management of painful musculoskeletal conditions. While effective for acute treatment, long-term use is not recommended due to potential side effects of both components.

Research suggests that this combination may provide more effective relief than either component alone for conditions where both pain and muscle spasm are present. However, the risk of adverse events increases with prolonged use, particularly in patients with cardiovascular, renal, or hepatic comorbidities.

Disclaimer

The information provided is for educational purposes only and does not replace professional medical advice. Always consult your healthcare provider before starting, stopping, or changing any treatment. This medication should only be used under proper medical supervision. Individual responses to medication may vary, and all potential risks and benefits should be discussed with your healthcare provider before beginning treatment.

"Brutaflam-MR 4 Tablet – Effective relief from muscle spasm and related pain. Available at RXDawa across India."

Brutaflam-MR 4 Tablet – Muscle Spasm Pain Relief | Buy Online at RXDawa