Vymada 50mg Tablet
Prescription Required
Marketer
Novartis India Ltd
SALT COMPOSITION
Sacubitril (24mg) + Valsartan (26mg)
Storage
Store below 30°C
Click here to view all substitutes
Product Introduction: Vymada 50mg is a prescription medication that contains Sacubitril (24mg) and Valsartan (26mg). It is primarily used for the treatment of heart failure with reduced ejection fraction (HFrEF). This combination drug belongs to the angiotensin receptor-neprilysin inhibitor (ARNI) class and is designed to reduce the risk of hospitalization and cardiovascular mortality in patients suffering from chronic heart failure.
Sacubitril works by inhibiting neprilysin, an enzyme responsible for breaking down beneficial peptides like natriuretic peptides, bradykinin, and adrenomedullin. These peptides play a crucial role in reducing blood pressure, decreasing sodium retention, and improving heart function. Valsartan, an angiotensin II receptor blocker (ARB), works by relaxing blood vessels and lowering blood pressure, ultimately reducing the strain on the heart.
Vymada is recommended for patients who cannot tolerate ACE inhibitors or require additional protection against worsening heart failure. It is often prescribed alongside beta-blockers and diuretics as part of a comprehensive treatment plan. Patients should strictly adhere to their doctor's prescribed dosage and follow regular monitoring guidelines to ensure safety and effectiveness.
Key Composition & Ingredients:
- Active Ingredients: Sacubitril (24mg) and Valsartan (26mg)
- Excipients: Microcrystalline cellulose, Lactose monohydrate, Magnesium stearate, Film coating agents
Uses of Vymada 50mg Tablet:
- Treatment of chronic heart failure with reduced ejection fraction (HFrEF)
- Helps reduce the risk of cardiovascular mortality and heart failure-related hospitalization
- Improves heart function and symptoms in patients with heart failure
- Recommended for patients who cannot tolerate ACE inhibitors
- Helps enhance long-term survival rates in patients with heart failure
- Reduces fluid buildup in the lungs and body by improving heart efficiency
- Supports better physical activity endurance in heart failure patients
Benefits of Vymada 50mg Tablet:
- Significantly reduces hospitalization rates due to worsening heart failure
- Enhances heart efficiency by improving circulation and reducing stress on the heart
- Helps control blood pressure and fluid retention
- Improves quality of life by reducing breathlessness and fatigue
- Prevents further cardiac deterioration, ensuring stable heart function over time
- Works effectively even in patients intolerant to ACE inhibitors
- Supports long-term management of heart failure by reducing cardiovascular stress
How Vymada 50mg Tablet Works: Vymada contains a combination of Sacubitril and Valsartan, working synergistically to enhance heart function and reduce stress on the cardiovascular system.
- Sacubitril inhibits neprilysin, increasing levels of beneficial peptides that promote vasodilation and sodium excretion.
- Valsartan blocks angiotensin II receptors, preventing blood vessel constriction and reducing blood pressure.
- Together, they improve heart efficiency and maintain stable circulation, reducing fluid overload in the body.
Mechanism of Action: Sacubitril is a neprilysin inhibitor, which prevents the breakdown of natriuretic peptides. These peptides help lower blood pressure, reduce sodium retention, and decrease stress on the heart. Valsartan, an angiotensin II receptor blocker (ARB), prevents vasoconstriction, thereby reducing blood pressure and strain on the heart. Together, they improve overall cardiac function and longevity in heart failure patients.
- Promotes vasodilation, reducing pressure on arteries and veins
- Enhances fluid excretion, preventing fluid overload
- Reduces cardiac workload, improving heart efficiency and function
Dosage of Vymada 50mg Tablet:
- Recommended Dose: One tablet twice daily, or as directed by a doctor
- Missed Dose: Take as soon as remembered unless it’s close to the next dose
- Overdose: Symptoms may include severe hypotension, dizziness, and kidney impairment. Seek immediate medical attention.
- Adjustments may be necessary for patients with kidney disease or low blood pressure
Mode of Action: Vymada reduces heart failure progression by promoting vasodilation, decreasing sodium retention, and preventing the negative effects of angiotensin II. This results in reduced blood pressure, improved circulation, and better heart function.
- Helps maintain optimal heart pumping capacity
- Prevents further structural damage to the heart
- Encourages better exercise tolerance in heart failure patients
How to Use Vymada 50mg Tablet:
- Swallow whole with water, do not crush or chew
- Take with or without food
- Adhere to the doctor’s prescribed schedule
- Do not abruptly stop medication without consulting your doctor
Directions for Use:
- Twice daily administration
- Regular blood pressure and kidney function monitoring is advised
- Avoid potassium supplements unless prescribed
- Monitor for any unusual swelling or breathing difficulties
Side Effects of Vymada 50mg Tablet:
- Common: Dizziness, hypotension, hyperkalemia
- Serious: Severe hypotension, kidney dysfunction
- Rare: Angioedema, liver enzyme abnormalities
- Uncommon but Severe: Severe allergic reactions, significant electrolyte imbalance
Side Effects & How to Manage Them:
- Dizziness: Avoid sudden movements, stay hydrated
- Low Blood Pressure: Monitor BP regularly, avoid dehydration
- Hyperkalemia: Follow a low-potassium diet
- Kidney dysfunction: Routine blood tests to monitor kidney health
- Swelling (Angioedema): Seek medical help immediately
Safety Measures & FDA Pregnancy Category:
- Category D: Not recommended during pregnancy
- Requires doctor’s approval before use in breastfeeding women
Diet & Lifestyle Advice:
- Follow a low-sodium, heart-healthy diet
- Engage in regular exercise as advised by a doctor
- Avoid smoking and excessive alcohol intake
- Ensure proper hydration but avoid excessive fluid intake
- Monitor weight daily to detect fluid retention early
Why Doctors Recommend This Medicine?
- Effective in reducing hospitalization and mortality rates
- Improves heart efficiency and circulation
- Offers an alternative to ACE inhibitors for heart failure patients
Substitutes & Alternative Medicines:
- Entresto 50mg
- Neparvis 50mg
- ARNI generic equivalents
Other Products from this Brand
- VYMADA 100MG STRIP OF 14 TABLETS
- VYMADA 200MG STRIP OF 7 TABLETS
Quick Tips:
- Take regularly for best results
- Avoid NSAIDs and high-potassium foods
- Monitor blood pressure and kidney function
- Report any signs of allergic reactions immediately
- Ensure frequent follow-ups with your cardiologist
- Monitor blood pressure and kidney function
Fact Box:
- Chemical Class: ARNI (Angiotensin Receptor Neprilysin Inhibitor)
- Habit Forming: No
- Therapeutic Class: Cardiovascular
- Action Class: ARNI
Useful Diagnostic Tests:
- Blood pressure monitoring
- Kidney function tests
- Electrolyte levels
More Information & References: For more details, consult a cardiologist or refer to official medical guidelines.
https://reference.medscape.com/drug/entresto-sacubitril-valsartan-1000010
https://www.novartis.com/us-en/sites/novartis_us/files/entresto.pdf
https://www.msnlabs.com/img/RxList/B33253-00.pdf
https://www.ema.europa.eu/en/documents/product-information/entresto-epar-product-information_en.pdf
https://www.accessdata.fda.gov/drugsatfda_docs/label/2024/207620s025,218591s000lbl.pdf
Disclaimer
THE CONTENTS OF THIS WEBSITE ARE FOR INFORMATIONAL PURPOSES ONLY AND ARE NOT INTENDED TO BE A SUBSTITUTE FOR PROFESSIONAL MEDICAL ADVICE, DIAGNOSIS, TREATMENT, OR PREVENTION OF A DISEASE OR MEDICAL CONDITION. PLEASE CONSULT A PHYSICIAN FOR THE TREATMENT AND/OR MANAGEMENT OF ANY DISEASE OR MEDICAL CONDITION WITHOUT DELAY.