Allegra 180mg for Allergies, Sneezing & Runny Nose

🌿 Allegra 180mg Tablet – Fast relief from allergies, sneezing, and nasal irritation.

Allegra 180mg Tablet

💊 Type: Prescription Medicine

🏢 Manufacturer: Sanofi India Ltd

🧪 Composition: Fexofenadine (180mg)

🌡️ Storage: Store below 30°C in a cool, dry place

🔁 Similar Medicines: [Click here to view substitutes]

Product Introduction

Allegra 180mg is a prescription-strength antihistamine medication containing fexofenadine hydrochloride (180mg) as its active ingredient. This non-sedating, second-generation antihistamine has revolutionized allergy treatment by providing effective symptom relief without the drowsiness commonly associated with older antihistamines.

At its core, Allegra works by selectively blocking H1 histamine receptors, effectively inhibiting the action of histamine—the key chemical mediator responsible for allergic symptoms. What distinguishes Allegra from first-generation antihistamines is its limited ability to cross the blood-brain barrier, resulting in minimal central nervous system effects. This characteristic allows patients to experience significant relief from allergy symptoms while maintaining mental alertness and cognitive function.

Allegra 180mg is specifically formulated for adults and adolescents suffering from moderate to severe allergic conditions. It provides rapid and long-lasting relief from the constellation of symptoms associated with seasonal allergic rhinitis (hay fever) and chronic idiopathic urticaria (hives), including sneezing, runny nose, itchy eyes, nasal congestion, and skin wheals. The 180mg dosage represents the maximum strength available, designed for once-daily administration to provide 24-hour symptom control.

Healthcare providers often recommend Allegra for patients who require powerful allergy relief without sedation, particularly those whose daily activities demand alertness, such as driving, operating machinery, or engaging in academic or professional work. The medication typically begins working within one hour of administration, with effects lasting throughout the 24-hour dosing interval.

Allegra has established an excellent safety profile over decades of clinical use. It demonstrates minimal drug interactions compared to many other antihistamines and does not significantly impact heart rhythm at recommended doses. Additionally, Allegra can be taken without regard to meals, although certain fruit juices may reduce its absorption.

For optimal results, Allegra should be taken as prescribed, typically once daily regardless of meals. Regular use during periods of allergen exposure helps maintain consistent symptom control, though many patients experience noticeable improvement after the first dose. As with any medication, Allegra should be used under medical supervision, particularly in patients with pre-existing kidney disease or those taking other medications.

Key Composition & Ingredients

Fexofenadine Hydrochloride (180mg): The active pharmaceutical ingredient that selectively blocks histamine H1 receptors without significant central nervous system penetration.
Inactive ingredients: May include microcrystalline cellulose, pregelatinized starch, croscarmellose sodium, magnesium stearate, hypromellose, povidone, titanium dioxide, silicon dioxide, and other excipients that help form the tablet and ensure proper drug delivery.

Uses of Allegra 180mg Tablet

Relief of symptoms associated with seasonal allergic rhinitis (hay fever)
Management of perennial allergic rhinitis (year-round allergies)
Treatment of chronic idiopathic urticaria (hives of unknown cause)
Relief from allergic conjunctivitis symptoms
Management of allergic skin reactions
Symptomatic relief from environmental allergen exposure
Treatment of allergies to dust mites, pet dander, pollen, and mold
Relief from itching associated with allergic conditions
Management of allergic symptoms in patients who cannot tolerate sedating antihistamines
As part of combination therapy for complex allergic conditions (with decongestants, nasal steroids, etc.)

Benefits of Allegra 180mg Tablet

Non-sedating formula: Provides allergy relief without causing significant drowsiness or impairment
24-hour protection: Once-daily dosing provides all-day symptom control
Rapid onset: Begins working within 1 hour of administration
Minimal drug interactions: Lower risk of interactions compared to many antihistamines
No significant cardiac effects: Does not prolong QT interval at recommended doses
No tolerance development: Effectiveness does not diminish with regular use
Flexible dosing: Can be taken without regard to meals (except certain fruit juices)
Excellent safety profile: Well-tolerated in long-term use
No anticholinergic effects: Minimal dry mouth, urinary retention, or blurred vision compared to older antihistamines
Suitable for daytime use: Allows normal daily activities without impairment

How Allegra 180mg Tablet Works

Mechanism of Action

Allegra (fexofenadine hydrochloride) works through a specific and selective mechanism:

Histamine receptor antagonism: Fexofenadine selectively binds to peripheral H1 histamine receptors, effectively blocking the action of histamine—the primary mediator of allergic responses.
Competitive inhibition: It competes with histamine for binding sites on H1 receptors without activating the receptor, preventing histamine from triggering allergic symptoms.
Limited blood-brain barrier penetration: Unlike first-generation antihistamines, fexofenadine has minimal ability to cross the blood-brain barrier, resulting in significantly reduced sedation and cognitive impairment.
Mast cell stabilization: Some research suggests fexofenadine may have additional anti-inflammatory effects by inhibiting the release of inflammatory mediators from mast cells and basophils.
Down-regulation of allergic cascade: By blocking H1 receptors, fexofenadine prevents the vasodilation, increased vascular permeability, and sensory nerve stimulation that cause typical allergy symptoms.

This selective action on peripheral histamine receptors allows Allegra to effectively control allergy symptoms while maintaining alertness and cognitive function.

Dosage of Allegra 180mg Tablet

Daily Dose

Adults and children 12 years and older: One 180mg tablet once daily
Alternative regimen: 60mg twice daily may be prescribed in some cases
Elderly patients: No specific dosage adjustment required based on age alone
Duration: Taken as needed for symptoms or continuously during allergy season

Missed Dose

Take as soon as remembered if within several hours of regular time
Skip the missed dose if it's almost time for the next dose
Do not take double doses to compensate for a missed tablet
Resume regular dosing schedule

Overdose

Symptoms may include dizziness, drowsiness, and dry mouth
Not typically life-threatening due to high safety margin
Seek medical attention if large overdose is suspected
Treatment is generally supportive

Mode of Action of Allegra 180mg Tablet

Allegra works by interrupting the allergic response cascade:

Receptor blockade: Fexofenadine binds to H1 histamine receptors on cells in blood vessels, airways, and other tissues, preventing histamine from attaching to these receptors.
Symptom prevention: By blocking histamine action, Allegra prevents:
- Vasodilation (which causes redness and warmth)
- Increased vascular permeability (leading to swelling and fluid leakage)
- Stimulation of nerve endings (causing itching and pain)
- Bronchoconstriction (causing breathing difficulties)
Extended relief: The 180mg formulation provides sufficient plasma concentration to maintain receptor blockade for 24 hours, allowing once-daily dosing.
Minimal sedation: Its chemical structure limits central nervous system penetration, avoiding the sedation common with first-generation antihistamines.

How to Use Allegra 180mg Tablet

Directions for Use

Take one tablet once daily with water
Can be taken with or without food
Avoid taking with fruit juices (especially apple, orange, or grapefruit) as they may decrease absorption
Take at approximately the same time each day for consistent effect
Swallow tablet whole; do not crush, chew, or break
For best results during allergy season, take regularly rather than intermittently
Allow at least 4 hours between Allegra and antacids containing aluminum or magnesium
Store at room temperature away from moisture and heat

Side Effects of Allegra 180mg Tablet

Common Side Effects

Headache (infrequent)
Mild fatigue
Nausea or stomach discomfort (rare)
Dry mouth (less common than with other antihistamines)
Mild dizziness

Serious Side Effects (Require Immediate Medical Attention)

Allergic reactions (rare): rash, itching, swelling, severe dizziness, difficulty breathing
Rapid or irregular heartbeat (very rare)
Significant drowsiness affecting activities (uncommon)
Unusual agitation or nervousness
Severe gastrointestinal distress

Managing Side Effects

Taking with food may help reduce stomach discomfort
Staying well-hydrated can help manage dry mouth
Most mild side effects resolve as the body adjusts to the medication
Report any persistent or concerning side effects to healthcare provider
Side effects are generally mild and less common than with many other antihistamines

Safety Advices of Allegra 180mg Tablet

Alcohol

No significant interaction with alcohol
However, alcohol may worsen allergy symptoms and potentially add to mild drowsiness
Moderation advised while using any medication

Pregnancy

FDA Pregnancy Category C
Use only if potential benefits justify potential risks to the fetus
Consult healthcare provider if pregnant or planning pregnancy
Limited human data available; animal studies show no harmful effects

Breastfeeding

Small amounts may pass into breast milk
Generally considered compatible with breastfeeding
Consult healthcare provider before use while nursing

Driving

Minimal effect on driving ability compared to older antihistamines
Assess individual response before driving or operating machinery
Some sensitive individuals may experience mild drowsiness

Kidney

Dosage adjustment recommended for patients with impaired kidney function
For severe kidney impairment: 60mg once daily typically recommended
Patients on dialysis may require further adjusted dosing
Regular monitoring advised for patients with kidney disease

Liver

No specific dosage adjustment required for mild to moderate liver impairment
Limited data available for severe liver impairment
Monitor for increased side effects in patients with significant liver disease

Children

Not recommended for children under 12 years for 180mg strength
Lower strengths available for pediatric use (30mg or 60mg)
Consult pediatrician for appropriate dosing in children

Older Patients

Generally well-tolerated in elderly patients
No specific age-based dosage adjustment required
Consider potential for reduced kidney function in elderly patients
May be preferred over sedating antihistamines in older adults

Lactation

Small amounts may pass into breast milk
No significant adverse effects reported in nursing infants
Consider benefits versus risks; generally considered compatible with breastfeeding

Allergy

Contraindicated in patients with known hypersensitivity to fexofenadine
Cross-reactivity with other antihistamines is possible but uncommon
Discontinue immediately if signs of allergic reaction occur

Warnings & Precautions of Allegra 180mg Tablet

Use with caution in patients with decreased kidney function
May cause mild drowsiness in some sensitive individuals
Avoid consumption with fruit juices as they may decrease drug absorption
Separate administration from antacids by at least 4 hours
Not recommended for children under 12 years (for 180mg dosage)
Inform physician about all medications being taken, including over-the-counter products
May mask symptoms of other conditions, potentially delaying diagnosis
Discontinue and seek medical attention if allergic reaction occurs
Limited data available for use during pregnancy and breastfeeding
Not intended for treatment of asthma or other respiratory conditions without additional therapy

Interactions with Allegra 180mg Tablet

Drug-Drug Interactions

Antacids containing aluminum or magnesium: May decrease absorption; separate by at least 4 hours
Ketoconazole and erythromycin: May increase fexofenadine levels; monitor for increased side effects
Rifampin: May decrease fexofenadine levels, potentially reducing effectiveness
Sedatives and tranquilizers: May have additive effects in sensitive individuals
St. John's Wort: May decrease fexofenadine levels

Drug-Food Interactions

Apple, orange, and grapefruit juice: May decrease absorption by up to 30%; take with water instead
Food: General food consumption does not significantly affect absorption
Grapefruit products: May affect drug metabolism; separate consumption by several hours

Contraindications of Allegra 180mg Tablet

Known hypersensitivity to fexofenadine or any component of the formulation
Severe kidney impairment (without dosage adjustment)
Children under 12 years of age (for 180mg dosage)
Rare hereditary problems of galactose intolerance, lactase deficiency, or glucose-galactose malabsorption (for formulations containing lactose)

Safety Measures & FDA Pregnancy Category

FDA Pregnancy Category C: Risk cannot be ruled out
Kidney function assessment recommended before prescribing to patients with known renal impairment
Careful monitoring in elderly patients with compromised organ function
No specific cardiovascular monitoring required at recommended doses
Use lowest effective dose for the shortest duration necessary
Avoid in patients with known hypersensitivity to ingredients

Diet & Lifestyle Advice

Avoid known allergens when possible to reduce need for medication
Consider using air purifiers in living spaces to reduce airborne allergens
Regularly wash bedding in hot water to control dust mites
Shower after outdoor activities during high pollen seasons
Keep windows closed during high pollen count days
Consider saline nasal irrigation as complementary therapy
Maintain adequate hydration to help thin mucus secretions
Monitor pollen forecasts to anticipate need for medication
Consider allergy testing to identify specific triggers
Use hypoallergenic bedding and pillow covers if allergic to dust mites

Why Doctors Recommend This Medicine

Physicians prescribe Allegra 180mg when:

Patient requires non-sedating allergy relief
Once-daily dosing is preferred for convenience and compliance
Patient operates vehicles or machinery and must remain alert
Other antihistamines have caused unacceptable drowsiness
Patient has not responded adequately to lower strength formulations
Stronger histamine blockade is needed for severe allergic manifestations
Patient has experienced side effects with other antihistamines
Medication interactions are a concern with alternative treatments
Patient needs long-term allergy management with minimal side effects
Maximum strength allergy relief is required without compromising daily functioning

Substitutes of Allegra 180mg Tablet & Alternative Medicines

Similar Antihistamines

Cetirizine (Zyrtec) 10mg - may cause more drowsiness than fexofenadine
Loratadine (Claritin) 10mg - similar non-sedating profile
Desloratadine (Clarinex) 5mg - active metabolite of loratadine
Levocetirizine (Xyzal) 5mg - more potent with potential for more sedation
Generic fexofenadine hydrochloride 180mg

Alternative Approaches

Intranasal corticosteroids for predominant nasal symptoms
Leukotriene modifiers (e.g., montelukast) for allergic rhinitis and asthma
Mast cell stabilizers (e.g., cromolyn) for allergic conjunctivitis
Nasal saline irrigation for symptom relief
Allergen immunotherapy (allergy shots) for long-term desensitization
Topical antihistamines for localized allergic reactions

Storage Guidelines

Store at room temperature between 68°F to 77°F (20°C to 25°C)
Keep away from excessive heat, moisture, and direct light
Store in the original container or packaging
Keep tightly closed when not in use
Keep out of reach of children
Do not store in bathroom medicine cabinets due to humidity
Do not use after the expiration date
Discard unused medication appropriately

User Feedback & Patient Concerns

Common patient questions include:

How quickly will symptoms improve?
Can I take this medication long-term?
Will it make me drowsy while driving?
Can I take it with my other medications?
Why should I avoid fruit juices with this medication?

Patients generally report high satisfaction with Allegra 180mg, citing effective symptom relief without significant drowsiness as the primary benefit. Most patients experience noticeable improvement within 1-3 hours after the first dose. The main concerns tend to be related to cost (especially compared to generic alternatives) and occasional reports of reduced effectiveness over time, which may actually reflect changes in allergy severity rather than medication tolerance.

Quick Tips for Allegra 180mg Tablet

Take with water, not fruit juice
Can be taken with or without food
For best results during allergy season, take regularly rather than only when symptoms appear
Allow at least 4 hours between Allegra and antacids
If you forget a dose, take it as soon as you remember unless it's almost time for your next dose
One tablet provides 24-hour protection from allergy symptoms
Non-drowsy formula allows normal daily activities
Store at room temperature in a dry place
Begins working within one hour for most people
If symptoms don't improve after 3 days, consult your doctor

Fact Box

Chemical Class

Piperidine derivative
Second-generation H1-receptor antagonist

Habit Forming

No, not habit-forming

Therapeutic Class

Non-sedating antihistamine

Action Class

Selective histamine H1-receptor antagonist

Useful Diagnostic Tests

Before and during treatment, the following tests may be recommended in specific situations:

Allergy skin testing or blood tests to identify specific allergens
Kidney function tests for patients with known renal impairment
Liver function tests if liver dysfunction is suspected
Complete blood count if symptoms suggest complications
Specific IgE testing to confirm allergic triggers

More Information & References

For additional information, consult:

National formularies and pharmacopoeias
Drug information databases
Manufacturer's package insert
Current allergy management guidelines
Consult your healthcare provider for personalized advice

Disclaimer

This information is for educational purposes only and is not intended as a substitute for medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions regarding a medical condition. Never disregard professional medical advice or delay seeking it because of information provided here. Individual results may vary, and benefits and risks should be discussed with your healthcare provider. This medication may not be suitable for everyone, and only your healthcare provider can determine if it is right for you.