Product Introduction
Bilasure M 20mg/10mg Tablet is an innovative combination medication that brings together two powerful therapeutic agents: Bilastine (20mg) and Montelukast (10mg). This dual-action formulation is specifically designed to provide comprehensive relief from allergic conditions by targeting different pathways involved in allergic responses. By combining these two medications with complementary mechanisms of action, Bilasure M offers enhanced therapeutic benefits for patients suffering from various allergic manifestations.
Bilastine, a second-generation antihistamine, effectively blocks histamine H1 receptors without crossing the blood-brain barrier significantly, resulting in potent anti-allergic effects with minimal sedation. Montelukast, a selective leukotriene receptor antagonist, inhibits the action of leukotrienes, which are important mediators in allergic inflammation. Together, these components provide a multi-faceted approach to managing allergic conditions by addressing both the immediate symptoms and the underlying inflammatory processes.
This combination is particularly valuable for patients with complex allergic conditions that involve both upper and lower respiratory systems, such as those with allergic rhinitis who also experience asthmatic symptoms, or patients with allergic rhinitis and concomitant urticaria. The once-daily dosing regimen of Bilasure M enhances patient compliance while providing 24-hour symptom control, making it a convenient therapeutic option for long-term management of chronic allergic conditions.
Bilasure M represents an advancement in allergic disorder management by targeting multiple pathophysiological aspects of the allergic cascade. Its formulation is based on the understanding that allergic diseases often involve various inflammatory mediators, and a multi-targeted approach may provide superior symptom control compared to monotherapy. This makes it an important addition to the therapeutic arsenal for allergologists, pulmonologists, and general practitioners dealing with patients suffering from complex allergic conditions.
As with any medication, Bilasure M should be used under medical supervision, with appropriate consideration of the patient's complete clinical picture, concomitant medications, and underlying health conditions. The balance of efficacy and safety makes this combination a valuable option in the management of allergic disorders when monotherapy with either agent alone proves insufficient.
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🌼 Bilasure M Tablet – Say goodbye to allergies! Fast relief from sneezing, itching & nasal irritation. |
Bilasure M 20mg/10mg Tablet
💊 Type: Prescription Medicine 🏢 Manufacturer: Sun Pharmaceutical Industries Ltd 🌡️ Storage: Store below 30°C in a cool, dry place 🔁 Similar Medicines: [Click here to view substitutes]
Key Composition & Ingredients
Active Ingredients:
Bilastine 20mg: A second-generation H1-antihistamine
Montelukast 10mg: A selective leukotriene receptor antagonist
Inactive Ingredients: May include:
Microcrystalline cellulose
Sodium starch glycolate
Magnesium stearate
Colloidal silicon dioxide
Hypromellose
Titanium dioxide
Polyethylene glycol
Pharmaceutical colorants
Uses of Bilasure M 20mg/10mg Tablet
Treatment of moderate to severe allergic rhinitis (seasonal and perennial)
Management of allergic rhinitis with concomitant asthmatic symptoms
Relief from nasal congestion, sneezing, itchy/runny nose, and eye symptoms
Control of urticaria (hives) and allergic skin conditions
Management of allergic manifestations resistant to monotherapy
Treatment of allergic rhinitis in patients with exercise-induced bronchoconstriction
Symptomatic relief in patients with allergic rhinitis and bronchial hyperreactivity
Management of allergies triggered by multiple allergens
Long-term control of chronic allergic conditions requiring dual pathway inhibition
Prevention of allergic symptoms in known seasonal triggers (prophylactic use)
Benefits of Bilasure M 20mg/10mg Tablet
Dual-action approach targeting multiple allergic pathways
Comprehensive control of both histamine and leukotriene-mediated symptoms
Reduced nasal congestion, sneezing, and rhinorrhea
Alleviation of allergic eye symptoms like itching, redness, and tearing
Improvement in bronchial symptoms in patients with allergic asthma
Once-daily dosing improving patient adherence
Minimal sedation compared to older antihistamines
Rapid onset of action for acute symptom relief
24-hour duration of action providing round-the-clock protection
Better quality of life with improved sleep and daytime functioning
May reduce the need for rescue medications like decongestants
Potential reduction in allergic progression (allergic march)
Improved control of mixed allergic conditions unresponsive to single agents
How Bilasure M 20mg/10mg Tablet Works
Bilasure M 20mg/10mg Tablet works through two complementary mechanisms to control allergic symptoms:
Bilastine (20mg):
Selectively blocks peripheral H1 histamine receptors, preventing histamine from binding to these receptors
Inhibits the early phase of allergic reaction characterized by itching, sneezing, rhinorrhea, and urticaria
Has minimal penetration across the blood-brain barrier, reducing central nervous system effects like sedation
Prevents histamine-mediated vasodilation and increased vascular permeability that cause tissue swelling
Has rapid onset of action (within 1 hour) and long duration (24 hours)
Does not undergo significant metabolism, being excreted largely unchanged
Montelukast (10mg):
Selectively antagonizes cysteinyl leukotriene receptor type 1 (CysLT1)
Blocks the action of leukotrienes (LTD4, LTC4, LTE4), which are important mediators in allergic inflammation
Inhibits the late phase allergic response characterized by nasal congestion and bronchial constriction
Reduces eosinophil recruitment and activation in allergic tissues
Decreases mucus production and inflammatory cell infiltration
Provides bronchodilation in patients with allergic asthma
Has anti-inflammatory effects in both upper and lower airways
The combination addresses both immediate allergic symptoms through antihistamine action and underlying inflammatory processes through leukotriene antagonism, providing comprehensive relief from allergic manifestations.
Dosage of Bilasure M 20mg/10mg Tablet
Daily Dose
Adults and adolescents (12 years and older):
The typical dosage is one tablet (Bilastine 20mg + Montelukast 10mg) once daily
Best taken at the same time each day for consistent relief
Can be taken for seasonal allergies throughout the allergy season or daily for perennial allergies
Duration of therapy as advised by healthcare provider based on individual response and condition
Missed Dose
Take as soon as remembered if within the same day
Skip the missed dose if it's almost time for the next scheduled dose
Do not double dose to make up for a missed tablet
Return to regular dosing schedule
Overdose
Symptoms may include headache, drowsiness, dizziness, dry mouth, increased heart rate, or abdominal pain
Seek immediate medical attention if overdose is suspected
Treatment is primarily supportive and symptomatic
How to Use Bilasure M 20mg/10mg Tablet
Take one tablet once daily as prescribed by your healthcare provider
Swallow the tablet whole with a full glass of water
Can be taken with or without food, but taking it consistently with respect to meals helps maintain steady drug levels
For optimal absorption of Bilastine component, take at least 1 hour before or 2 hours after a meal
Take at approximately the same time each day to maintain consistent blood levels
Do not crush, chew, or break the tablet unless specifically instructed by your healthcare provider
Continue taking even if you feel well, as this medication may be prescribed for long-term control of chronic allergic conditions
For seasonal allergies, start taking before exposure to allergens when possible
Side Effects of Bilasure M 20mg/10mg Tablet
Common Side Effects
Headache
Fatigue or drowsiness (though less common than with older antihistamines)
Dry mouth
Mild gastrointestinal disturbances (nausea, abdominal discomfort)
Dizziness
Increased appetite
Mild elevation in liver enzymes
Uncommon Side Effects
Sleep disturbances or insomnia
Anxiety or irritability
Prolonged QT interval (rare, primarily in susceptible individuals)
Altered taste perception
Palpitations
Increased thirst
Flatulence
Skin rashes
Rare Side Effects
Hypersensitivity reactions (skin rash, itching, swelling)
Severe allergic reactions (anaphylaxis)
Neuropsychiatric events (mood changes, depression, suicidal ideation)
Significant elevation in liver enzymes
Eosinophilic conditions including Churg-Strauss syndrome (extremely rare with Montelukast)
How to Manage Side Effects
Dry mouth: Drink plenty of water, chew sugarless gum, use saliva substitutes
Headache: Over-the-counter pain relievers may help (consult doctor first)
Drowsiness: Take the medication in the evening if drowsiness occurs
GI discomfort: Taking with food may help reduce stomach upset
Report any mood changes, unusual behavior, or allergic reactions to your healthcare provider immediately
Regular follow-up with healthcare provider to monitor for any adverse effects
Safety Advice for Bilasure M 20mg/10mg Tablet
Alcohol
CAUTION: Alcohol may enhance the sedative effects of this medication. Limit alcohol consumption while taking Bilasure M.
Pregnancy
CONSULT DOCTOR: Limited data available. Use only if potential benefits outweigh risks. Discuss with your healthcare provider if you are pregnant or planning pregnancy.
Breastfeeding
CONSULT DOCTOR: Both active ingredients may pass into breast milk. Caution is advised. Discuss with your healthcare provider before use during breastfeeding.
Driving
CAUTION: While Bilastine causes less sedation than older antihistamines, monitor your response to the medication before driving or operating machinery, especially during initial treatment.
Kidney
CAUTION: Dose adjustment may be necessary in patients with severe renal impairment. Consult your doctor if you have kidney problems.
Liver
CAUTION: Both active ingredients are metabolized by the liver. Regular monitoring of liver function may be advisable for long-term use, especially in patients with pre-existing liver conditions.
Children
NOT RECOMMENDED: Safety and efficacy not established in children under 12 years of age. Alternative age-appropriate formulations should be considered for younger patients.
Older Adults
CAUTION: Elderly patients may be more sensitive to side effects. Start with lower doses if necessary and monitor for adverse effects.
Allergy
CONTRAINDICATED: Do not use if allergic to Bilastine, Montelukast, or any component of the formulation.
Warnings & Precautions of Bilasure M 20mg/10mg Tablet
Neuropsychiatric Events: Monitor for behavioral changes, depression, or suicidal thoughts, particularly in patients with a history of mental health disorders
QT Prolongation: Use with caution in patients with cardiac conditions or those taking other medications that may prolong the QT interval
Drug Interactions: Potential interactions with certain medications that affect liver enzymes
Phenylketonuria: Some formulations may contain aspartame; check ingredients if you have phenylketonuria
Eosinophilic Conditions: Rare reports of eosinophilic conditions including Churg-Strauss syndrome with Montelukast
Not for Acute Attacks: Not effective for treatment of acute asthma attacks or status asthmaticus
Renal Impairment: Use with caution in severe renal impairment
Hepatic Impairment: Caution advised in patients with liver dysfunction
Elderly Patients: May be more susceptible to adverse effects
Concomitant Medications: Inform doctor about all current medications due to potential interactions
Abrupt Discontinuation: Avoid stopping suddenly, especially if used for asthma control
Interactions with Bilasure M 20mg/10mg Tablet
Drug-Drug Interactions
P-glycoprotein inhibitors (e.g., ketoconazole, erythromycin, cyclosporine): May increase Bilastine levels
CYP3A4 inducers (e.g., rifampin, phenytoin): May decrease Montelukast effectiveness
CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin): May increase Montelukast levels
QT-prolonging medications (certain antiarrhythmics, antibiotics, antipsychotics): Potential additive effect on QT prolongation
Sedatives and CNS depressants: May enhance sedative effects
Other antihistamines: Potential additive effects and increased risk of side effects
Phenobarbital: May decrease effectiveness of Montelukast
Warfarin: Montelukast may enhance anticoagulant effect in some patients
Drug-Food Interactions
Grapefruit juice: May interfere with the metabolism of both active ingredients
High-fat meals: May reduce the absorption rate of Bilastine
Food generally: Bilastine absorption is reduced when taken with food; take at least 1 hour before or 2 hours after meals for optimal effect
Contraindications of Bilasure M 20mg/10mg Tablet
Known hypersensitivity to Bilastine, Montelukast, or any component of the formulation
Severe renal impairment (creatinine clearance <30 ml/min) without appropriate dose adjustment
Patients with history of angioedema with previous antihistamine use
Congenital prolongation of the QT interval or use with other medications known to prolong the QT interval
Patients with galactose intolerance, Lapp lactase deficiency, or glucose-galactose malabsorption (if the formulation contains lactose)
Pregnancy and breastfeeding (unless potential benefits outweigh risks)
Children under 12 years of age
Diet & Lifestyle Advice
Allergen Avoidance:
Identify and avoid known allergic triggers
Use air purifiers and allergen-proof bedding if appropriate
Keep windows closed during high pollen seasons
Shower and change clothes after outdoor activities during pollen season
Environmental Control:
Reduce house dust mite exposure through regular cleaning
Control indoor humidity to prevent mold growth
Consider removing carpets in favor of hard flooring if dust allergies are severe
Avoid pet dander if known to trigger symptoms
Dietary Considerations:
Take Bilastine component on an empty stomach for optimal absorption
Avoid grapefruit juice which may interfere with medication metabolism
Be aware of potential food allergies that may contribute to symptoms
Stay well hydrated to help thin mucus secretions
Lifestyle Modifications:
Monitor air quality reports and limit outdoor activities when pollen or pollution levels are high
Saline nasal rinses may help remove allergens and support medication effectiveness
Practice stress reduction techniques, as stress can worsen allergic responses
Maintain good sleep hygiene, as allergies can disrupt sleep quality
Why Doctors Recommend This Medicine
Healthcare providers prescribe Bilasure M 20mg/10mg Tablet for several specific reasons:
It provides dual-pathway inhibition targeting both histamine and leukotriene-mediated allergic responses
Effective for patients with mixed allergic conditions affecting multiple body systems
Particularly beneficial for allergic rhinitis patients with asthmatic components
The once-daily dosing improves patient adherence to treatment
Minimal sedation compared to older antihistamines enhances quality of life
Both components have established safety and efficacy profiles
Offers comprehensive symptom control for patients who have not responded adequately to monotherapy
Reduces the need for multiple medications, simplifying treatment regimens
Provides both immediate relief and addresses underlying inflammation
May help prevent progression of allergic conditions when used consistently
Substitutes of Bilasure M 20mg/10mg Tablet & Alternative Medicines
Similar Combination Products:
Other brands containing Bilastine + Montelukast in same or different strengths
Combinations of different second-generation antihistamines with Montelukast
Monotherapy Alternatives:
Antihistamines alone: Bilastine, Fexofenadine, Desloratadine, Levocetirizine, Cetirizine
Leukotriene modifiers alone: Montelukast, Zafirlukast
Intranasal corticosteroids: Fluticasone, Mometasone, Budesonide sprays
Intranasal antihistamines: Azelastine, Olopatadine nasal sprays
Other Therapeutic Approaches:
Combined use of separate antihistamine and leukotriene modifier tablets
Intranasal corticosteroid + oral antihistamine combinations
Allergen-specific immunotherapy (for long-term modification of allergic response)
Nasal saline irrigation as adjunctive therapy
In severe cases: Short courses of oral corticosteroids
For urticaria: H2 antihistamines as add-on therapy
Storage Guidelines
Store at room temperature between 20-25°C (68-77°F)
Protect from light and moisture
Keep away from direct sunlight
Store in the original package or container
Keep out of reach of children
Do not use after the expiration date
Do not store in bathroom medicine cabinets due to heat and humidity
Do not freeze
User Feedback & Patient Concerns
Common feedback from patients includes:
Most report significant improvement in both nasal and eye symptoms
Many appreciate the non-sedating nature compared to older antihistamines
Patients with asthma symptoms often note improvement in breathing alongside allergic symptom relief
Some report initial adjustment period with mild headaches that typically resolve
Generally good tolerability with few discontinuations due to side effects
Occasional reports of mild drowsiness, especially during initial therapy
Some patients mention increased effectiveness compared to single-agent therapy
Questions about long-term safety are common, especially regarding Montelukast
Some patients report delayed onset of full effect (may take several days)
Concerns about cost compared to individual components purchased separately
Quick Tips
Take consistently at the same time each day for optimal effect
For best absorption of Bilastine component, take on an empty stomach
Allow at least 2 weeks of regular use to evaluate full effectiveness
Continue using even when symptoms improve to maintain control
Be aware of mood changes and report them promptly to your doctor
During severe allergy seasons, starting treatment before exposure to allergens is beneficial
Carry medication information with you when traveling
Inform all healthcare providers about this medication before any procedures
Keep a symptom diary during initial use to track effectiveness
For seasonal allergies, don't discontinue abruptly when season ends; follow doctor's guidance
Fact Box
Chemical Class: H1-antihistamine (Bilastine) + Leukotriene receptor antagonist (Montelukast)
Habit Forming: No
Therapeutic Class: Antiallergic combination
Action Class: Histamine H1-receptor antagonist + Cysteinyl leukotriene CysLT1 receptor antagonist
Useful Diagnostic Tests
Before or during treatment, your doctor may recommend:
Allergy skin testing to identify specific triggers
Blood tests for specific IgE antibodies
Complete blood count to evaluate eosinophil levels
Pulmonary function tests if asthmatic symptoms are present
ECG in patients with cardiac risk factors or before long-term therapy
Liver function tests for baseline and monitoring during long-term use
Renal function tests in patients with kidney problems
References
Clinical guidelines for the management of allergic rhinitis
Pharmacology references for antihistamines and leukotriene modifiers
Clinical studies on combination therapy for allergic disorders
Safety profiles of Bilastine and Montelukast
Therapeutic guidelines for allergic conditions
Link to credible health sources:
Disclaimer
This information is provided for educational purposes only and is not intended as a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified healthcare provider with any questions you may have regarding a medical condition or treatment. Never disregard professional medical advice or delay in seeking it because of information you have read here. This medication should only be used under the supervision of a qualified healthcare provider.
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