Aldigesic-SP for Muscle, Joint & Post-Operative Pain

💊 Aldigesic-SP Tablet – Effective pain relief and anti-inflammatory support.

Aldigesic-SP Tablet

💊 Type: Prescription Medicine

🏢 Manufacturer: Alkem Laboratories Ltd

🧪 Composition: Aceclofenac (100mg) + Paracetamol (325mg) + Serratiopeptidase (10mg)

🌡️ Storage: Store below 30°C in a cool, dry place

🔁 Similar Medicines: [Click here to view substitutes]

Product Introduction

Aldigesic-SP is an advanced triple-combination medication featuring Aceclofenac (100mg), Paracetamol (325mg), and Serratiopeptidase (10mg). This powerful formulation offers a comprehensive approach to pain management by combining anti-inflammatory, analgesic, and proteolytic enzyme actions in a single tablet.

The unique strength of Aldigesic-SP lies in its multi-modal mechanism of action. Aceclofenac, a well-established NSAID (Non-Steroidal Anti-Inflammatory Drug), effectively reduces inflammation and provides pain relief by inhibiting inflammatory mediators. Paracetamol complements this action with additional pain-relieving and fever-reducing properties through central mechanisms. The addition of Serratiopeptidase, a proteolytic enzyme, sets this formulation apart by helping to reduce swelling and improving the distribution of the other active ingredients to inflamed tissues.

Aldigesic-SP is particularly valued for its effectiveness in managing conditions with significant inflammation and edema, such as post-traumatic swelling, post-operative inflammation, sports injuries, and various arthritic conditions. The enzyme component helps break down inflammatory proteins and debris at injury sites, potentially accelerating the healing process while the analgesic components provide pain relief.

Healthcare providers often prescribe Aldigesic-SP when conventional NSAID-paracetamol combinations prove insufficient, especially in cases with substantial tissue swelling. The tablet's triple-action formula makes it suitable for patients requiring enhanced anti-inflammatory effects alongside pain management, offering a more targeted approach to inflammatory conditions.

With its well-balanced composition, Aldigesic-SP typically begins relieving symptoms within 30-60 minutes of administration, with the enzymatic action contributing to reduced swelling over subsequent hours. The tablet is designed for convenient oral administration, typically with meals to minimize gastrointestinal effects, making it a practical option for both acute conditions and short-term management of chronic inflammatory disorders.

As with all medications, Aldigesic-SP should be used under medical supervision, particularly when used beyond short durations. The dosage regimen is tailored to individual patient needs, considering the condition being treated, its severity, and the patient's overall health profile.

Key Composition & Ingredients

Aceclofenac (100mg): A non-steroidal anti-inflammatory drug (NSAID) that selectively inhibits cyclooxygenase enzymes, reducing prostaglandin synthesis and inflammation.
Paracetamol (325mg): An analgesic and antipyretic that works centrally to reduce pain perception and fever.
Serratiopeptidase (10mg): A proteolytic enzyme that breaks down proteins and fibrin in inflamed or injured tissues, reducing swelling and improving circulation.
Inactive ingredients: May include microcrystalline cellulose, starch, magnesium stearate, talc, silicon dioxide, and coating materials.

Uses of Aldigesic-SP Tablet

Treatment of osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis
Management of post-traumatic pain and swelling from sprains, strains, and injuries
Relief from post-operative pain and inflammation
Management of dental pain and post-dental surgery swelling
Treatment of musculoskeletal disorders with significant inflammation
Management of sports injuries with tissue swelling
Relief from tendonitis and bursitis
Symptomatic treatment of acute gout attacks
Management of ear, nose, and throat inflammatory conditions
Relief from menstrual pain (dysmenorrhea) with associated inflammation

Benefits of Aldigesic-SP Tablet

Triple-action formulation: Provides anti-inflammatory, analgesic, and anti-edema effects
Enhanced anti-inflammatory effect: Serratiopeptidase complements NSAID action for better inflammation control
Improved tissue penetration: Enzymatic activity may enhance distribution of active ingredients
Faster resolution of swelling: Proteolytic action helps reduce edema more effectively
Comprehensive pain management: Addresses pain through multiple pathways
Potential for faster recovery: May accelerate healing by clearing inflammatory debris
Reduced dependency on single high-dose medications: Combined approach may lower individual component dosages
Convenience: Single tablet delivers three therapeutic agents, improving compliance
Synergistic effect: Components work together for enhanced therapeutic outcomes

How Aldigesic-SP Tablet Works

Mechanism of Action

Aldigesic-SP combines three distinct mechanisms for a comprehensive therapeutic approach:

Aceclofenac (100mg):
- Primarily inhibits cyclooxygenase-2 (COX-2) enzymes
- Reduces prostaglandin production at inflammation sites
- Decreases pro-inflammatory cytokine release
- Inhibits neutrophil adhesion
- Suppresses pain signal transmission in peripheral tissues
Paracetamol (325mg):
- Acts on the central nervous system to inhibit prostaglandin synthesis
- Influences cannabinoid and serotonergic pain pathways
- Affects pain perception in the hypothalamus
- Produces antipyretic effects through hypothalamic action
- Complements the peripheral action of aceclofenac
Serratiopeptidase (10mg):
- Hydrolyzes inflammatory proteins and peptides
- Breaks down fibrin and inflammatory exudates
- Reduces fluid retention in tissues
- Enhances antibiotic penetration (when used concurrently)
- May improve microcirculation in affected areas
- Facilitates removal of damaged tissue and inflammatory debris

The combined action provides more comprehensive management of inflammation and pain than conventional NSAID-analgesic combinations alone.

Dosage of Aldigesic-SP Tablet

Daily Dose

Adults: Typically one tablet twice daily, preferably after meals
Maximum duration: Usually limited to 5-7 days for acute conditions unless otherwise prescribed
For chronic conditions: Dosing schedule determined by physician based on response and tolerability

Missed Dose

Take as soon as remembered if within a few hours
Skip the missed dose if close to the next scheduled dose
Do not double the dose to compensate for a missed tablet
Resume regular dosing schedule

Overdose

Symptoms may include nausea, vomiting, abdominal pain, liver damage, kidney problems, and gastrointestinal bleeding
Seek immediate medical attention if overdose is suspected
Treatment may include gastric lavage, activated charcoal, N-acetylcysteine (for paracetamol toxicity), and supportive care

Mode of Action of Aldigesic-SP Tablet

Aldigesic-SP works through complementary pathways:

Inflammation reduction: Aceclofenac inhibits prostaglandin synthesis, while serratiopeptidase breaks down inflammatory proteins
Pain control: Both aceclofenac and paracetamol block pain signals through peripheral and central mechanisms
Edema reduction: Serratiopeptidase degrades fibrin and proteins that trap fluid in tissues
Improved circulation: Reduced swelling leads to better blood flow to affected areas
Enhanced tissue penetration: Proteolytic activity may improve distribution of other active ingredients

This multi-modal approach targets multiple aspects of the inflammatory response and pain pathway.

How to Use Aldigesic-SP Tablet

Directions for Use

Take with a full glass of water
Best taken after meals to minimize gastric irritation
Swallow the tablet whole; do not crush, chew, or break
Take at evenly spaced intervals to maintain therapeutic levels
Follow physician's instructions regarding timing and duration
Do not exceed prescribed dosage or duration
Store at room temperature away from moisture and direct light
Monitor for symptom improvement and any adverse effects

Side Effects of Aldigesic-SP Tablet

Common Side Effects

Dyspepsia (indigestion)
Nausea and occasional vomiting
Abdominal discomfort or pain
Heartburn
Dizziness or headache
Mild diarrhea or constipation
Flatulence

Serious Side Effects (Require Immediate Medical Attention)

Gastrointestinal bleeding or ulceration
Severe allergic reactions (rash, itching, swelling, severe dizziness)
Liver or kidney dysfunction
Cardiovascular events (in high-risk patients)
Unusual bleeding or bruising
Severe skin reactions
Respiratory symptoms (in sensitive individuals)
Edema or fluid retention

Managing Side Effects

Take with food to reduce gastrointestinal effects
Stay well-hydrated while on medication
Avoid alcohol consumption
Report any unusual symptoms promptly
Regular monitoring of liver and kidney function for extended use
Consider protective medications if prescribed for longer periods

Safety Advices of Aldigesic-SP Tablet

Alcohol

Avoid alcohol consumption as it increases the risk of gastrointestinal bleeding and liver toxicity
Combination may enhance sedative effects and impair alertness

Pregnancy

Not recommended during pregnancy, especially in the third trimester
May cause complications for mother and fetus
Always consult healthcare provider if pregnant or planning pregnancy

Breastfeeding

Use with caution during breastfeeding
Components may pass into breast milk
Short-term use may be considered if benefits outweigh risks
Consider temporary interruption of breastfeeding during treatment

Driving

May cause dizziness or drowsiness in some patients
Assess individual response before operating vehicles or machinery
Avoid driving if experiencing any central nervous system effects

Kidney

Use with caution in patients with kidney impairment
Dosage adjustment may be necessary
Regular kidney function monitoring recommended for extended use
Avoid in severe renal insufficiency

Liver

May affect liver function
Not recommended for patients with severe liver disease
Requires regular liver function monitoring during extended therapy
Discontinue if abnormal liver tests develop

Children

Generally not recommended for children under 18 years
Safety and efficacy not established in pediatric populations
Alternative pediatric formulations should be considered

Older Patients

May require lower doses due to decreased clearance
Higher risk of side effects, especially gastrointestinal, renal, and cardiovascular
Closer monitoring recommended
Consider shorter treatment duration when possible

Lactation

Use caution during lactation
Short-term use may be acceptable if benefits outweigh risks
Consider temporary interruption of breastfeeding for extended therapy
Monitor infant for adverse effects if breastfeeding is continued

Allergy

Contraindicated in patients with known hypersensitivity to any component
Cross-reactivity may occur with other NSAIDs
Monitor for signs of allergic reaction, especially with first doses
Discontinue immediately if hypersensitivity reactions occur

Warnings & Precautions of Aldigesic-SP Tablet

Not recommended for patients with history of gastrointestinal bleeding or ulcers
Use cautiously in patients with cardiovascular disease, hypertension, or heart failure
May worsen asthma in sensitive individuals
Risk of serious skin reactions, especially during first month of treatment
Long-term use increases risk of cardiovascular events
May mask signs of infection by reducing fever and inflammation
Regular monitoring of blood pressure recommended during treatment
Discontinue if signs of liver or kidney damage appear
Not recommended before or after coronary artery bypass graft surgery
Use caution in patients with coagulation disorders
May interact with anticoagulant therapy
Can cause sodium and fluid retention
Serratiopeptidase component may affect blood coagulation
Increased risk of GI bleeding in elderly patients

Interactions with Aldigesic-SP Tablet

Drug-Drug Interactions

Anticoagulants/Antiplatelets: Increased bleeding risk due to both NSAID and enzyme components
Corticosteroids: Enhanced risk of gastrointestinal ulceration
Diuretics: Reduced effectiveness and increased nephrotoxicity risk
ACE inhibitors/ARBs: Potential for decreased effectiveness and renal impairment
Lithium: May increase lithium plasma levels
Methotrexate: Increased toxicity of methotrexate
Other NSAIDs: Additive side effects and increased toxicity
Cyclosporine: Enhanced nephrotoxicity
Antibiotics: Serratiopeptidase may enhance antibiotic penetration
Quinolone antibiotics: Increased risk of seizures
Antidiabetic agents: Possible alteration of blood glucose control

Drug-Food Interactions

Food delays absorption but reduces gastrointestinal side effects
High-fat meals may alter absorption rate
Acidic beverages may reduce serratiopeptidase activity
Avoid alcohol as it increases risk of liver toxicity and gastrointestinal bleeding

Contraindications of Aldigesic-SP Tablet

Active gastric/duodenal ulceration or gastrointestinal bleeding
History of NSAID-induced gastrointestinal bleeding or perforation
Severe heart failure
Severe liver or kidney dysfunction
Third trimester of pregnancy
Known hypersensitivity to aceclofenac, paracetamol, serratiopeptidase, or other NSAIDs
Patients with aspirin-induced asthma, urticaria, or allergic reactions
Hemophilia or other bleeding disorders
Concomitant use of other NSAIDs
Children under 18 years of age
Pre-operative settings in major surgical procedures due to enzyme effects
Conditions with elevated bleeding risk

Safety Measures & FDA Pregnancy Category

FDA Pregnancy Category: C (D in third trimester)
Regular monitoring of blood pressure in hypertensive patients
Periodic liver and kidney function tests during extended therapy
Use the lowest effective dose for the shortest duration
Immediate discontinuation if signs of allergic reaction occur
Special caution in elderly patients due to increased risk of adverse effects
Consider gastroprotective agents for patients at high risk of GI complications
Not recommended for patients scheduled for surgical procedures

Diet & Lifestyle Advice

Maintain adequate hydration while taking this medication
Follow an anti-inflammatory diet rich in omega-3 fatty acids
Consider physical therapy and appropriate exercises for joint conditions
Apply hot or cold packs as appropriate for the condition
Practice stress reduction techniques to help manage pain
Maintain healthy weight to reduce pressure on joints
Avoid activities that exacerbate pain during acute flare-ups
Consider ergonomic modifications to prevent musculoskeletal strain
Supplement with vitamin D and calcium if appropriate for bone health
Incorporate gentle stretching to maintain mobility

Why Doctors Recommend This Medicine

Physicians prescribe Aldigesic-SP when:

Significant inflammation and swelling accompany pain
Conventional NSAID-paracetamol combinations provide insufficient relief
Post-traumatic or post-surgical edema requires management
Enhanced tissue penetration of anti-inflammatory agents is desired
Accelerated resolution of inflammatory exudates is beneficial
Managing conditions with both pain and significant tissue swelling
Targeting multiple pathways of inflammation is necessary
Patient has responded well to enzyme therapy in the past

Substitutes of Aldigesic-SP Tablet & Alternative Medicines

Similar Combination Products

Other Aceclofenac + Paracetamol + Serratiopeptidase brands
Diclofenac + Paracetamol + Serratiopeptidase combinations
Nimesulide + Paracetamol + Serratiopeptidase combinations

Alternative Approaches

NSAID + Paracetamol combinations without enzyme component
COX-2 selective inhibitors (for patients at risk of GI complications)
Topical analgesics and anti-inflammatories
Physical therapy and rehabilitation
Acupuncture and massage therapy
Heat and cold therapy
Transcutaneous electrical nerve stimulation (TENS)
Bromelain or other enzyme-based supplements

Storage Guidelines

Store at room temperature (15-30°C/59-86°F)
Keep away from direct sunlight, heat, and moisture
Store in the original package or container
Keep tightly closed when not in use
Keep out of reach of children
Do not use after the expiration date
Discard unused medication appropriately
Protect from humidity as moisture may degrade the enzyme component

User Feedback & Patient Concerns

Common patient questions include:

How quickly will I notice reduced swelling?
Can I take this medication long-term?
What should I do if I experience stomach pain?
Can I take this with my other medications?
Will this interfere with blood-thinning medications?

Patients generally report good efficacy for conditions with significant swelling, with feedback highlighting faster resolution of edema compared to standard NSAID combinations. Concerns primarily relate to gastrointestinal effects and potential interactions with other medications.

Quick Tips for Aldigesic-SP Tablet

Take with food to minimize stomach upset
Complete the full course as prescribed by your doctor
Do not increase dosage without medical advice
Report any unusual bleeding or bruising immediately
Avoid taking other NSAIDs or paracetamol-containing products concurrently
Stay well-hydrated while taking this medication
Keep track of total daily paracetamol intake from all sources
Inform all healthcare providers about this medication before procedures
Use particular caution if on blood thinners
Consider taking in the morning and evening to maintain consistent levels

Fact Box

Chemical Class

Aceclofenac: Phenylacetic acid derivative (NSAID)
Paracetamol: Para-aminophenol derivative
Serratiopeptidase: Proteolytic enzyme (metalloprotease)

Habit Forming

No, not habit-forming

Therapeutic Class

Anti-inflammatory, Analgesic, and Enzymatic combination

Action Class

Non-selective COX inhibitor (Aceclofenac)
Central analgesic and antipyretic (Paracetamol)
Proteolytic enzyme (Serratiopeptidase)

Useful Diagnostic Tests

Before and during treatment, the following tests may be recommended:

Complete blood count
Liver function tests
Kidney function tests
Stool occult blood test (for extended use)
Blood pressure monitoring
Coagulation profile (especially for extended use)
Cardiac evaluation for high-risk patients
Inflammatory markers (ESR, CRP) to monitor effectiveness

More Information & References

For additional information, consult:

National formularies and pharmacopoeias
Drug information databases
Manufacturer's package insert
Current clinical practice guidelines for inflammatory conditions
Consult your healthcare provider for personalized advice
Research publications on combination therapy in inflammatory conditions

Disclaimer

This information is for educational purposes only and is not intended as a substitute for medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions regarding a medical condition. Never disregard professional medical advice or delay seeking it because of information provided here. Individual results may vary, and benefits and risks should be discussed with your healthcare provider before starting any new medication regimen.