Autrin Hematinic Capsule for Iron Deficiency & Anemia – Benefits, Dosage & Precautions

🔴 Autrin Hematinic Capsule – Boost your iron levels and fight fatigue with trusted nutritional support.

Autrin Hematinic Capsule with Cyanocobalamin, Iron & Folic Acid

💊 Type: Prescription Medicine

🏢 Manufacturer: Pfizer Ltd

🧪 Composition: Iron (98.6mg) + Cyanocobalamin (15mcg) + Folic Acid (1.5mg)

🌡️ Storage: Store below 25°C in a cool, dry place

🔁 Similar Medicines: [Click here to view substitutes]

Product Introduction

Autrin Hematinic Capsule is a comprehensive iron supplement formulation combining three essential blood-building nutrients: Iron (98.6mg), Cyanocobalamin (15mcg), and Folic Acid (1.5mg). This powerful triple-action combination makes it particularly effective for addressing various forms of anemia and supporting optimal hematopoiesis (blood cell production).

Iron serves as the cornerstone of this formulation, providing the fundamental building block for hemoglobin—the oxygen-carrying protein in red blood cells. The substantial iron content (98.6mg) delivers a therapeutic dose suitable for treating iron deficiency anemia, the most common nutritional deficiency worldwide. Cyanocobalamin, the synthetic form of vitamin B12 (15mcg), complements iron's action by supporting red blood cell maturation and DNA synthesis. Meanwhile, folic acid (1.5mg) works synergistically with both iron and vitamin B12, playing a crucial role in the production of healthy red blood cells and the prevention of megaloblastic anemia.

Autrin Hematinic Capsule is specifically designed for individuals suffering from or at risk of anemia due to nutritional deficiencies, increased physiological demands, or malabsorption issues. Its balanced formulation makes it particularly valuable for pregnant women, who have increased requirements for all three nutrients to support maternal and fetal health. The capsule is also beneficial for menstruating women experiencing heavy blood loss, elderly individuals with absorption difficulties, vegetarians and vegans who may have limited dietary sources of these nutrients, and patients recovering from surgery or illness.

Healthcare providers often recommend Autrin as both a therapeutic intervention for established anemia and as a preventive measure for high-risk individuals. The capsule's formulation allows for convenient once-daily dosing in most cases, though the specific regimen may be adjusted based on individual needs and the severity of the deficiency being addressed.

While Autrin begins replenishing nutrient stores immediately after absorption, the full clinical benefits—including increased energy levels, improved concentration, and enhanced overall well-being—typically become apparent after several weeks of consistent use. For optimal results, Autrin should be taken as prescribed by a healthcare professional, with adherence to recommended timing and dietary considerations to maximize absorption and minimize potential side effects.

Key Composition & Ingredients

• Iron (98.6mg): Typically provided as ferrous sulfate or ferrous fumarate, essential for hemoglobin synthesis and oxygen transport.
• Cyanocobalamin (15mcg): Synthetic form of vitamin B12, critical for red blood cell formation, neurological function, and DNA synthesis.
• Folic Acid (1.5mg): Vitamin B9, necessary for DNA synthesis, red blood cell maturation, and prevention of neural tube defects.
• Inactive ingredients: May include gelatin (capsule shell), magnesium stearate, silicon dioxide, microcrystalline cellulose, and potentially colorants or preservatives.

Uses of Autrin Hematinic Capsule

• Treatment of iron deficiency anemia
• Management of vitamin B12 deficiency (pernicious anemia)
• Treatment of folate deficiency anemia
• Prevention of nutritional anemias in high-risk populations
• Supplementation during pregnancy to prevent maternal anemia and fetal neural tube defects
• Support during periods of increased iron demands (adolescence, heavy menstruation)
• Nutritional support for vegetarians and vegans
• Adjunctive therapy in malabsorption disorders
• Post-surgical nutritional support
• Management of anemia in chronic kidney disease (under medical supervision)
• Supplementation during cancer treatment when deficiencies are present

Benefits of Autrin Hematinic Capsule

• Comprehensive anemia management: Addresses multiple nutritional causes of anemia simultaneously
• Enhanced red blood cell production: Provides essential nutrients for all stages of erythropoiesis
• Improved oxygen transport: Supports hemoglobin formation for better tissue oxygenation
• Increased energy levels: Combats fatigue associated with anemia
• Neurological support: B12 component helps maintain nervous system health
• Cardiovascular benefits: Proper red blood cell function supports heart health
• Pregnancy support: Reduces risk of maternal anemia and fetal neural tube defects
• Cognitive function: Improves concentration and mental clarity often affected by anemia
• Immune system support: Adequate iron and B vitamins are important for immune function
• Synergistic formulation: Components work together for enhanced effectiveness
• Convenient single-preparation: Simplifies supplementation regimen

How Autrin Hematinic Capsule Works

Mechanism of Action

Autrin works through complementary mechanisms to support healthy blood formation:

1. Iron (98.6mg):

   • Absorbed primarily in the duodenum and upper jejunum
   • Transported in the blood by transferrin to bone marrow
   • Incorporated into hemoglobin in developing red blood cells
   • Essential for oxygen binding and transport throughout the body
   • Stores in the liver, spleen, and bone marrow as ferritin and hemosiderin
   • Participates in numerous enzymatic processes beyond hemoglobin synthesis

2. Cyanocobalamin (15mcg):

   • Requires intrinsic factor from stomach for absorption in terminal ileum
   • Essential for DNA synthesis in rapidly dividing cells, including red blood cell precursors
   • Functions as a cofactor in methionine synthase reaction
   • Supports myelin formation and maintenance of the nervous system
   • Works with folate in the one-carbon metabolism pathway
   • Necessary for converting homocysteine to methionine

3. Folic Acid (1.5mg):

   • Absorbed in the proximal small intestine
   • Converted to its active form, tetrahydrofolate
   • Essential for purine and thymidylate synthesis (DNA building blocks)
   • Works with vitamin B12 in the synthesis of DNA
   • Crucial for rapid cell division, particularly in red blood cell formation
   • Supports methylation reactions throughout the body

The combined action ensures all essential nutrients for erythropoiesis are available, addressing multiple potential deficiencies that can cause anemia.

Dosage of Autrin Hematinic Capsule

Daily Dose

• Adults: Typically one capsule daily or as directed by healthcare provider
• Pregnant women: Usually one capsule daily throughout pregnancy
• For treatment of established deficiency: May be increased to one capsule twice daily initially
• Maintenance therapy: Generally one capsule daily

Missed Dose

• Take as soon as remembered if within the same day
• Skip the missed dose if remembered the next day
• Do not take double doses to make up for missed doses
• Resume regular dosing schedule

Overdose

• Symptoms may include nausea, vomiting, abdominal pain, diarrhea, and constipation
• Iron overdose can be serious, especially in children
• Seek immediate medical attention if overdose is suspected
• Treatment may include gastric lavage, deferoxamine (for iron toxicity), and supportive care

Mode of Action of Autrin Hematinic Capsule

Autrin works through three coordinated pathways:

1. Hemoglobin synthesis: Iron provides the essential building block for hemoglobin, the oxygen-carrying protein in red blood cells.

2. DNA synthesis and cell maturation: Both cyanocobalamin and folic acid are crucial for DNA synthesis, ensuring proper development and maturation of red blood cells.

3. Metabolic support: The components function as cofactors in various metabolic pathways required for healthy blood formation and cellular function.

This multi-pathway approach ensures comprehensive support for erythropoiesis and optimal oxygen-carrying capacity of the blood.

How to Use Autrin Hematinic Capsule

Directions for Use

• Take with a full glass of water
• Best taken on an empty stomach (1 hour before or 2 hours after meals) for optimal iron absorption
• If stomach upset occurs, may be taken with food (note: certain foods may reduce iron absorption)
• Avoid taking with dairy products, tea, coffee, or antacids which can inhibit iron absorption
• Take at the same time each day to maintain consistent levels
• Swallow capsule whole; do not crush, chew, or open
• Store at room temperature away from moisture and direct light
• Continue treatment for the full prescribed duration, even after feeling better

Side Effects of Autrin Hematinic Capsule

Common Side Effects

• Gastrointestinal discomfort (nausea, abdominal pain)
• Constipation
• Black or dark-colored stools (not harmful, caused by unabsorbed iron)
• Temporary staining of teeth (if capsule is opened)
• Metallic taste
• Mild heartburn

Serious Side Effects (Require Immediate Medical Attention)

• Severe allergic reactions (rash, itching, swelling, severe dizziness)
• Severe abdominal pain
• Persistent vomiting
• Signs of iron overload (joint pain, fatigue, weakness)
• Unusual bleeding or bruising
• Bright red blood in stool

Managing Side Effects

• Taking with food if gastrointestinal upset occurs
• Increasing dietary fiber and fluid intake to manage constipation
• Temporary dose reduction if side effects are troublesome
• Taking capsule at bedtime to reduce awareness of digestive symptoms
• Regular monitoring of iron levels during extended therapy

Safety Advices of Autrin Hematinic Capsule

Alcohol

• Alcohol may decrease absorption of vitamins and iron
• May exacerbate gastrointestinal side effects
• Best to avoid or limit alcohol consumption during treatment

Pregnancy

• Generally considered safe and often specifically prescribed during pregnancy
• The folic acid component is particularly important in preventing neural tube defects
• Always use under medical supervision during pregnancy

Breastfeeding

• Generally safe during breastfeeding
• Components may pass into breast milk but are not known to harm nursing infants
• May help maintain maternal iron stores depleted during pregnancy and breastfeeding

Driving

• No known effects on ability to drive or operate machinery
• If dizziness occurs as a side effect, caution is advised

Kidney

• Use with caution in patients with kidney disease
• Dosage adjustment may be necessary in severe renal impairment
• Regular monitoring recommended for long-term use in kidney patients

Liver

• Use with caution in patients with liver disorders
• Iron may accumulate in the liver if clearance is impaired
• Not recommended in hemochromatosis or other iron overload conditions

Children

• Formulation and dosage generally intended for adults
• Pediatric formulations available for children
• Keep out of reach of children as iron overdose can be fatal in children

Older Patients

• May benefit due to increased prevalence of nutritional deficiencies
• May require monitoring due to potential for decreased kidney function
• May have altered absorption due to age-related gastrointestinal changes

Lactation

• Generally safe during lactation
• Supplements during breastfeeding may help maintain maternal nutrient stores
• No significant adverse effects reported in breastfed infants

Allergy

• Contraindicated in patients with known hypersensitivity to any component
• Seek immediate medical attention if signs of allergic reaction occur
• Alternative formulations may be available for patients with specific allergies

Warnings & Precautions of Autrin Hematinic Capsule

• Not suitable for patients with hemochromatosis or other iron overload disorders
• Use with caution in patients with peptic ulcer disease
• Requires medical evaluation before use in thalassemia and sideroblastic anemia
• May interfere with certain diagnostic tests (occult blood tests, radiographic procedures)
• Not a substitute for proper diagnosis of the cause of anemia
• May mask symptoms of vitamin B12 deficiency if taken without proper B12 supplementation
• Regular monitoring of blood counts recommended during treatment
• High doses of folic acid may decrease seizure threshold in susceptible individuals
• Not indicated for treatment of pernicious anemia unless adequate B12 is included
• Excessive intake may lead to secondary iron overload in susceptible individuals
• Patients with malabsorption disorders may require specialized formulations or higher doses

Interactions with Autrin Hematinic Capsule

Drug-Drug Interactions

• Antacids: Reduce iron absorption; separate by at least 2 hours
• Tetracycline antibiotics: Decreased absorption of both tetracyclines and iron; separate by at least 2 hours
• Quinolone antibiotics: Reduced antibiotic absorption; separate by at least 2 hours
• Levodopa: Iron may reduce its absorption and effectiveness
• Thyroid medications: Iron may impair absorption; separate by at least 4 hours
• Bisphosphonates: Reduced absorption of bisphosphonates; separate by at least 2 hours
• Methyldopa: Reduced absorption when taken with iron
• Chloramphenicol: May interfere with response to iron therapy
• Phenytoin: May reduce folate levels
• Methotrexate: Antagonizes folate action, monitor closely

Drug-Food Interactions

• Dairy products: Calcium in dairy reduces iron absorption
• Tea and coffee: Tannins bind iron and reduce absorption
• Phytates (whole grains, legumes): May reduce iron absorption
• Vitamin C-rich foods: Enhance non-heme iron absorption
• High-calcium foods: May reduce iron absorption if taken simultaneously
• Oxalate-rich foods (spinach, rhubarb): May slightly impair iron absorption

Contraindications of Autrin Hematinic Capsule

• Hemochromatosis or other iron storage disorders
• Hemosiderosis
• Untreated vitamin B12 deficiency with neurological symptoms
• Known hypersensitivity to any component of the formulation
• Active peptic ulcer disease (relative contraindication)
• Patients receiving repeated blood transfusions
• Regional enteritis or ulcerative colitis in active phase
• Intestinal strictures or obstruction
• Patients with malignancies except where iron deficiency is confirmed
• Hemolytic anemia unless accompanied by iron deficiency

Safety Measures & FDA Pregnancy Category

• FDA Pregnancy Category: A (benefits outweigh risks, especially for folic acid component)
• Regular monitoring of hemoglobin, hematocrit, and ferritin levels during therapy
• Periodic assessment of B12 and folate status for long-term users
• Evaluation of response to therapy after 4-8 weeks
• Use lowest effective dose after correction of deficiency
• Store in child-resistant containers to prevent accidental overdose
• Consider periodic liver function tests during prolonged therapy

Diet & Lifestyle Advice

• Consume vitamin C-rich foods with iron supplements to enhance absorption
• Maintain a balanced diet rich in iron sources (lean meats, beans, fortified cereals)
• Include folate-rich foods (leafy greens, citrus fruits, beans)
• Consider vitamin B12 dietary sources (meat, fish, dairy) especially for vegetarians
• Avoid excessive zinc supplementation which may interfere with iron absorption
• Maintain adequate hydration to prevent constipation
• Separate calcium supplements from iron intake by at least 2 hours
• Consider cooking in cast iron cookware for additional dietary iron
• Regular moderate exercise may help improve anemia symptoms
• Limit caffeine intake which can interfere with iron absorption

Why Doctors Recommend This Medicine

Physicians prescribe Autrin Hematinic Capsule when:

• Multiple nutritional deficiencies are present or suspected
• Single-nutrient supplements have proven insufficient
• Preventive therapy is needed for high-risk populations
• Comprehensive support for red blood cell production is required
• Patient has poor compliance with multiple separate supplements
• During pregnancy to prevent maternal anemia and neural tube defects
• For patients with malabsorption requiring higher doses
• Following bariatric surgery or other procedures affecting nutrient absorption
• For vegetarians/vegans at risk of B12 deficiency alongside iron deficiency
• When laboratory tests indicate combined deficiencies

Substitutes of Autrin Hematinic Capsule & Alternative Medicines

Similar Combination Products

• Various iron + folate + B12 formulations
• Iron + multivitamin combinations
• Prenatal vitamins with similar components
• Iron + B-complex formulations

Alternative Approaches

• Individual iron, B12, and folate supplements
• Injectable vitamin B12 for severe deficiency or absorption issues
• Iron infusions for severe deficiency or intolerance to oral preparations
• Natural food sources rich in these nutrients
• Different iron salt formulations (ferrous gluconate, ferrous fumarate)
• Extended-release iron formulations for reduced side effects
• Liposomal iron preparations for enhanced absorption
• Heme iron polypeptide formulations

Storage Guidelines

• Store at room temperature (15-30°C/59-86°F)
• Keep away from direct sunlight and moisture
• Store in the original container with the lid tightly closed
• Keep out of reach of children (iron overdose can be fatal in children)
• Do not store in bathroom medicine cabinets due to humidity
• Do not freeze
• Discard expired capsules appropriately
• Do not transfer to unlabeled containers

User Feedback & Patient Concerns

Common patient questions include:

• How long will it take to feel better?
• Why do stools change color during treatment?
• How long should treatment continue?
• Can I take calcium supplements while using this product?
• Is constipation an expected side effect?

Patients generally report improvement in energy levels and reduction in symptoms of anemia after several weeks of consistent use. Side effects most commonly reported include constipation and digestive discomfort, which often improve with continued use or dietary adjustments.

Quick Tips for Autrin Hematinic Capsule

• Take with vitamin C (orange juice, etc.) to enhance iron absorption
• Avoid dairy products, tea, coffee, and antacids within 2 hours of taking
• Dark stools are normal and indicate the presence of iron
• Complete the full course of treatment even after feeling better
• Regular blood tests can track your progress
• Take at the same time daily to establish a routine
• If you experience constipation, increase water and fiber intake
• Store away from children as iron overdose can be very dangerous
• Some improvement in fatigue may be noticed within 1-2 weeks, but full benefit takes longer
• Don't take with other multivitamins unless approved by your doctor

Fact Box

Chemical Class

• Iron: Mineral/elemental nutrient
• Cyanocobalamin: Water-soluble vitamin (B12)
• Folic Acid: Water-soluble vitamin (B9)

Habit Forming

• No, not habit-forming

Therapeutic Class

• Hematinics/Antianemic preparation
• Nutritional supplement

Action Class

• Iron supplement
• Vitamin B complex
• Red blood cell formation support

Useful Diagnostic Tests

Before and during treatment, the following tests may be recommended:

• Complete blood count (CBC)
• Serum ferritin level
• Serum iron, TIBC, and transferrin saturation
• Serum B12 level
• Serum and RBC folate levels
• Reticulocyte count to assess response to therapy
• Peripheral blood smear
• Iron stores assessment (when indicated)
• Liver function tests (for long-term therapy)
• Stool occult blood test (to rule out bleeding as cause of anemia)

More Information & References

For additional information, consult:

• National formularies and pharmacopoeias
• Clinical practice guidelines for anemia management
• Nutritional reference standards
• Manufacturer's package insert
• Consult your healthcare provider for personalized advice
• Dietary guidelines for specific nutrient requirements

Disclaimer

This information is for educational purposes only and is not intended as a substitute for medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions regarding a medical condition. Never disregard professional medical advice or delay seeking it because of information provided here. Individual results may vary, and benefits and risks should be discussed with your healthcare provider before starting any supplement regimen. Proper diagnosis of the cause of anemia should always precede treatment.