Axcer 90mg for Heart Attack, Stroke & Angina – Benefits, Dosage & Safety Info

❤️ Axcer 90mg Tablet – Protect your heart from heart attack, stroke & angina. 

Axcer 90mg Tablet

💊 Type: Prescription Medicine

🏢 Manufacturer: Sun Pharmaceutical Industries Ltd

🧪 Composition: Ticagrelor (90mg)

🌡️ Storage: Store below 30°C in a cool, dry place

🔁 Similar Medicines: [Click here to view substitutes]

Product Introduction

Axcer 90mg Tablet, containing 90mg of Ticagrelor as its active ingredient, is an advanced antiplatelet medication prescribed primarily to prevent blood clots in patients with acute coronary syndrome (ACS) and those undergoing coronary procedures. As a direct-acting P2Y12 receptor antagonist, Ticagrelor works differently from older antiplatelet medications by reversibly binding to platelets, offering both faster onset and more consistent inhibition of platelet aggregation.

Developed as a more effective alternative to clopidogrel, Ticagrelor has demonstrated superior outcomes in reducing the risk of cardiovascular death, heart attack, and stroke in high-risk cardiac patients. Its unique pharmacological profile allows for more predictable antiplatelet activity without requiring metabolic activation in the liver, which makes it effective across a broader patient population, including those with genetic variations that might limit the effectiveness of other antiplatelet drugs.

Axcer 90mg is typically administered twice daily, making it an important component of dual antiplatelet therapy (DAPT) when combined with low-dose aspirin. This regimen is especially crucial during the first year following an acute coronary event or stent placement. Clinical studies have shown that patients on Ticagrelor experience fewer ischemic events compared to those on standard therapy, though this enhanced efficacy comes with a slightly increased risk of bleeding that requires careful monitoring.

The medication represents a significant advancement in preventing thrombotic complications in cardiovascular disease management. While more costly than older antiplatelet agents, its improved clinical outcomes often justify its use in high-risk scenarios. Healthcare providers carefully weigh the benefits of enhanced clot prevention against the risks of bleeding when prescribing Axcer 90mg Tablet, considering each patient's unique cardiovascular risk profile, comorbidities, and likelihood of requiring surgical procedures in the near future.

For patients with ACS or coronary stents, Axcer provides crucial protection during the highest risk period for stent thrombosis and recurrent cardiovascular events. Regular medical follow-up is essential while taking this medication to monitor its effectiveness and manage any potential side effects.

Key Composition & Ingredients

• Active Ingredient: Ticagrelor 90mg
• Inactive Ingredients: Mannitol, dibasic calcium phosphate, sodium starch glycolate, hydroxypropyl cellulose, magnesium stearate, hydroxypropyl methylcellulose, titanium dioxide, talc, polyethylene glycol, and ferric oxide yellow

Uses of Axcer Tablet

• Prevention of atherothrombotic events in patients with Acute Coronary Syndrome (ACS)
• Reduction of cardiovascular death, myocardial infarction, and stroke in patients with ACS
• Prevention of stent thrombosis in patients undergoing percutaneous coronary intervention (PCI)
• Maintenance therapy after coronary stent placement
• Secondary prevention in patients with a history of myocardial infarction (heart attack)

Benefits of Axcer Tablet

• More effective than clopidogrel in reducing major adverse cardiovascular events
• Faster onset of antiplatelet action compared to other P2Y12 inhibitors
• More consistent platelet inhibition across diverse patient populations
• Reversible binding allows quicker recovery of platelet function after discontinuation
• Reduces cardiovascular mortality in high-risk ACS patients
• Does not require metabolic activation, effective regardless of genetic variations

How Axcer Tablet Works (Mechanism of Action)

Ticagrelor is a direct-acting, reversible P2Y12 receptor antagonist that prevents platelet activation and aggregation. Unlike thienopyridines (like clopidogrel), it:

1. Binds directly to the P2Y12 receptor on platelets without requiring metabolic activation
2. Changes the conformation of the receptor, preventing ADP from binding
3. Blocks ADP-mediated platelet activation and subsequent aggregation
4. Acts reversibly, allowing for faster restoration of platelet function after discontinuation
5. Also affects adenosine reuptake, potentially providing additional cardiovascular benefits

Dosage of Axcer Tablet

• Initial Loading Dose: Usually 180mg (two 90mg tablets) given as a single dose
• Maintenance Dose: 90mg twice daily, approximately 12 hours apart
• Duration: Generally continued for 12 months after ACS or stent placement, unless otherwise directed
• Missed Dose: Take as soon as remembered if within 12 hours; otherwise, wait for next scheduled dose
• Overdose: Seek immediate medical attention; may cause excessive bleeding, dizziness, or confusion

Mode of Action of Axcer Tablet

Axcer (Ticagrelor) has a unique mode of action as it directly and reversibly binds to the P2Y12 receptor on platelets. This direct binding provides faster onset and more potent inhibition of platelet aggregation compared to prodrugs like clopidogrel that require hepatic conversion to active metabolites.

How to Use Axcer Tablet

• Take exactly as prescribed by your doctor
• Typically taken twice daily, approximately 12 hours apart
• Can be taken with or without food
• Swallow the tablet whole with water; do not crush or chew
• Usually taken together with low-dose aspirin (as directed by your doctor)
• Maintain consistent timing of doses for optimal effect

Side Effects of Axcer Tablet

Common side effects:

• Bleeding (including minor bruising, nosebleeds)
• Shortness of breath (dyspnea)
• Headache
• Dizziness
• Nausea
• Back pain or extremity pain

Serious side effects (require immediate medical attention):

• Major bleeding events
• Intracranial hemorrhage
• Severe dyspnea or difficulty breathing
• Signs of allergic reaction (rash, itching, swelling)
• Unusual bruising or bleeding that doesn't stop
• Severe or persistent dizziness

Safety Advice for Axcer Tablet

• Alcohol: Avoid alcohol as it increases bleeding risk
• Pregnancy: Category C - Use only if benefits outweigh potential risks
• Breastfeeding: Not recommended; excretion in breast milk unknown
• Driving: Use caution until individual response is known; may cause dizziness
• Kidney Function: Use with caution in severe kidney disease; no dosage adjustment required for mild to moderate impairment
• Liver Function: Contraindicated in severe liver disease; use with caution in mild to moderate liver impairment
• Children: Safety and efficacy not established in pediatric populations
• Older Patients: Higher bleeding risk; monitor closely but no specific dosage adjustment required
• Allergies: Avoid if allergic to ticagrelor or any components of the formulation

Warnings & Precautions for Axcer Tablet

• History of intracranial hemorrhage
• Active bleeding or bleeding disorders
• Planned surgical procedures
• Moderate to severe liver disease
• History of sick sinus syndrome or heart block without pacemaker
• Concomitant use of strong CYP3A4 inhibitors or inducers
• Discontinue 5-7 days before major surgery when possible
• Risk of breathing difficulties, especially in patients with COPD or asthma
• Regular monitoring of complete blood count recommended

Interactions with Axcer Tablet

Drug Interactions:

• Strong CYP3A4 inhibitors (ketoconazole, clarithromycin) increase ticagrelor levels
• Strong CYP3A4 inducers (rifampin, phenytoin) decrease effectiveness
• Simvastatin and lovastatin: Increased statin levels; limit statin dose
• Digoxin: Increased digoxin levels; monitor digoxin levels
• Opioids: May reduce ticagrelor absorption and effectiveness
• NSAIDs: Increased bleeding risk
• Warfarin and other anticoagulants: Substantially increased bleeding risk

Food Interactions:

• Grapefruit juice may increase ticagrelor levels; avoid regular consumption
• High-fat meals may slightly delay absorption but do not affect overall bioavailability

Contraindications of Axcer Tablet

• Active pathological bleeding
• History of intracranial hemorrhage
• Severe hepatic impairment
• Hypersensitivity to ticagrelor or any component of the formulation
• Concomitant use of strong CYP3A4 inhibitors
• Concomitant use with strong CYP3A4 inducers

Diet & Lifestyle Advice

• Maintain a heart-healthy diet low in saturated fats and sodium
• Regular moderate exercise as recommended by your physician
• Avoid activities with high risk of injury or bleeding
• Quit smoking and limit alcohol consumption
• Wear medical alert identification indicating antiplatelet therapy
• Inform all healthcare providers about ticagrelor use before procedures

Why Doctors Recommend This Medicine

Physicians recommend Axcer (Ticagrelor) because it provides superior reduction in cardiovascular events compared to clopidogrel, offers more consistent platelet inhibition across patient populations, and has a reversible mechanism allowing faster recovery of platelet function when medication needs to be stopped before surgery.

Substitutes of Axcer Tablet & Alternative Medicines

• Clopidogrel (Plavix)
• Prasugrel (Effient)
• Generic ticagrelor from various manufacturers
• Aspirin (as a single antiplatelet agent in select cases)

Storage Guidelines

• Store at room temperature between 59-86°F (15-30°C)
• Keep away from moisture and direct light
• Keep out of reach of children
• Keep in original container with the desiccant to protect from moisture

Quick Tips for Axcer Tablet

• Always take with the prescribed dose of aspirin
• Do not discontinue without consulting your doctor
• Inform all healthcare providers about this medication before procedures
• Carry medical identification indicating you are on antiplatelet therapy
• Report any unusual bleeding or breathing difficulties immediately
• Continue taking even if you feel better; this is preventive therapy

Fact Box

• Chemical Class: Cyclopentyl-triazolo-pyrimidine
• Habit Forming: No
• Therapeutic Class: Antiplatelet agent
• Action Class: P2Y12 platelet receptor antagonist

Useful Diagnostic Tests

• Complete blood count
• Liver function tests
• Kidney function tests
• Bleeding time assessment
• ECG and cardiac function tests
• Platelet function tests when needed

Disclaimer

This information is for educational purposes only and not a substitute for professional medical advice. Always consult your healthcare provider before starting, stopping, or changing any treatment regimen. Individual responses to medication may vary.